TY - JOUR T1 - Administering analgesia sublingually is a suitable option for children with acute abdominal pain in the emergency department. JF - Acta Paediatr Y1 - 2019 A1 - Cozzi, Giorgio A1 - Zanchi, Chiara A1 - Chiaretti, Antonio A1 - Tipo, Vincenzo A1 - Cernich, Marta A1 - D'Anna, Carolina A1 - Fantacci, Claudia A1 - Conversano, Ester A1 - Zanon, Davide A1 - Ronfani, Luca A1 - Barbi, Egidio AB -

AIM: Acute abdominal pain is a frequent complaint in children attending emergency departments. The aim of this study was to investigate the pain score reductions when children with acute abdominal pain received medication sublingually.

METHODS: We carried out a multicentre randomised controlled trial in three children's hospitals in Italy between March 2015 and June 2017. Children from four to 18 years of age with acute abdominal pain were recruited if their self-reported pain was at least six on a scale from 0-10. The children were randomised to receive ketorolac 0.5 mg/kg (n = 70) or tramadol 2 mg/kg (n = 70) sublingually or a melt in the mouth powder of 20 mg/kg paracetamol (n = 70). The main study outcome was the pain scores for the three drugs after two hours.

RESULTS: The 210 children (58.6% girls) had a median age of 12 years with an interquartile range of 9-14.3. The median pain scores at two hours were not significantly different between ketorolac 2.0 (interquartile ranges, IQR 0.0-4.3) and tramadol 3.0 (IQR 1.0-5.0) vs paracetamol 3.0 (IQR 0.8-5.0). The median pain reductions were all 5.0 points.

CONCLUSION: Delivering analgesia sublingually was a suitable option for pain relief in children with acute abdominal pain in the emergency department.

VL - 108 IS - 1 U1 - http://www.ncbi.nlm.nih.gov/pubmed/30043434?dopt=Abstract ER - TY - JOUR T1 - Adolescent with painful vesicular otitis and vertigo. JF - Arch Dis Child Educ Pract Ed Y1 - 2019 A1 - Conversano, Ester A1 - Cozzi, Giorgio A1 - Poropat, Federico A1 - Di Mascio, Alberto A1 - Salis, Simona A1 - Grasso, Domenico Leonardo A1 - Barbi, Egidio VL - 104 IS - 2 U1 - http://www.ncbi.nlm.nih.gov/pubmed/29440126?dopt=Abstract ER - TY - JOUR T1 - Afebrile seizures in infants: Never forget magnesium! JF - J Paediatr Child Health Y1 - 2018 A1 - Minute, Marta A1 - Ventura, Giovanna A1 - Giorgi, Rita A1 - Faletra, Flavio A1 - Costa, Paola A1 - Cozzi, Giorgio VL - 54 IS - 4 U1 - http://www.ncbi.nlm.nih.gov/pubmed/29411453?dopt=Abstract ER - TY - JOUR T1 - Anti-transglutaminase 6 Antibody Development in Children With Celiac Disease Correlates With Duration of Gluten Exposure. JF - J Pediatr Gastroenterol Nutr Y1 - 2018 A1 - De Leo, Luigina A1 - Aeschlimann, Daniel A1 - Hadjivassiliou, Marios A1 - Aeschlimann, Pascale A1 - Salce, Nicola A1 - Vatta, Serena A1 - Ziberna, Fabiana A1 - Cozzi, Giorgio A1 - Martelossi, Stefano A1 - Ventura, Alessandro A1 - Not, Tarcisio AB -

OBJECTIVES: Antibodies against transglutaminase 6 (anti-TG6) have been implicated in neurological manifestations in adult patients with genetic gluten intolerance, and it is unclear whether autoimmunity to TG6 develops following prolonged gluten exposure. We measured the anti-TG6 in children with celiac disease (CD) at the diagnosis time to establish a correlation between these autoantibodies and the duration of gluten exposure. We investigated a correlation between anti-TG6 and the presence of neurological disorders.

METHODS: Anti-TG6 (IgA/IgG) were measured by ELISA in sera of children with biopsy-proven CD and of children experiencing gastrointestinal disorders. CD patients positive for anti-TG6 were retested after 2 years of gluten-free diet (GFD).

RESULTS: We analyzed the sera of 274 CD children and of 121 controls. Anti-TG6 were detected in 68/274 (25%) CD patients and in 19/121 (16%) controls, with significant difference between the 2 groups (P = 0.04). None of the CD patients and of the controls testing positive for anti-TG6 were experiencing neurological disorders. Eleven of 18 (61%) CD patients with other autoimmune diseases were positive for anti-TG6. In CD patients, a significant correlation between the gluten exposure before the CD diagnosis and anti-TG6 concentration was found (P = 0.006 for IgA; P < 0.0001 for IgG). After GFD anti-TG6 concentrations were significantly reduced (P < 0.001). No significant correlation was observed between anti-TG6 and anti-TG2 serum concentrations.

CONCLUSIONS: Anti-TG6 are more prevalent in children with untreated CD in the absence of overt neurological disorders. The synthesis of the anti-TG6 is related to a longer exposure to gluten before the CD diagnosis, and the autoimmunity against TG6 is gluten dependent and disappeared during GFD.

VL - 66 IS - 1 U1 - http://www.ncbi.nlm.nih.gov/pubmed/28542044?dopt=Abstract ER - TY - JOUR T1 - Authors' Reply to M.S. Raghuraman: "Intranasal Dexmedetomidine for Procedural Sedation in Children, a Suitable Alternative to Chloral Hydrate". JF - Paediatr Drugs Y1 - 2017 A1 - Cozzi, Giorgio A1 - Norbedo, Stefania A1 - Barbi, Egidio KW - Administration, Intranasal KW - Child KW - Chloral Hydrate KW - Dexmedetomidine KW - Humans KW - Hypnotics and Sedatives KW - Infant VL - 19 IS - 4 U1 - http://www.ncbi.nlm.nih.gov/pubmed/28660554?dopt=Abstract ER - TY - JOUR T1 - Analgesia by cooling vibration during venipuncture in children with cognitive impairment. JF - Acta Paediatr Y1 - 2015 A1 - Schreiber, Silvana A1 - Cozzi, Giorgio A1 - Rutigliano, Rosaria A1 - Assandro, Paola A1 - Tubaro, Martina A1 - Cortellazzo Wiel, Luisa A1 - Ronfani, Luca A1 - Barbi, Egidio AB -

AIM: Children with cognitive impairment experience pain more frequently than healthy children and are more likely to require venipuncture or intravenous cannulation for various procedures. They are frequently unable to report pain and often receive poor pain assessment and management. This study assessed the effectiveness of physical analgesia during vascular access in children with cognitive impairments.

METHODS: We conducted a prospective randomised controlled study at a tertiary-level children's hospital in Italy from April to May 2015 to assess whether a cooling vibration device called Buzzy decreased pain during venipuncture and intravenous cannulation in children with cognitive impairment. None of the children had verbal skills and the main cognitive impairments were cerebral palsy, epileptic encephalopathy and genetic syndromes.

RESULTS: We tested 70 children with a median age of nine years: 34 in the Buzzy group and 36 in the no-intervention group. Parents were trained in the use of the Noncommunicating Children's Pain Checklist - postoperative version scale, and they reported no or mild procedural pain in 32 cases (91.4%) in the Buzzy group and in 22 cases (61.1%) in the no-intervention group (p = 0.003).

CONCLUSION: Cooling vibration analgesia during vascular access reduced pain in children with cognitive impairment.

U1 - http://www.ncbi.nlm.nih.gov/pubmed/26401633?dopt=Abstract ER -