%0 Journal Article %J Biol Blood Marrow Transplant %D 2012 %T Allogeneic hematopoietic stem cell transplantation for Philadelphia-positive acute lymphoblastic leukemia in children and adolescents: a retrospective multicenter study of the Italian Association of Pediatric Hematology and Oncology (AIEOP). %A Fagioli, Franca %A Zecca, Marco %A Rognoni, Carla %A Lanino, Edoardo %A Balduzzi, Adriana %A Berger, Massimo %A Messina, Chiara %A Favre, Claudio %A Rabusin, Marco %A Lo Nigro, Luca %A Masetti, Riccardo %A Prete, Arcangelo %A Locatelli, Franco %K Adolescent %K Antineoplastic Combined Chemotherapy Protocols %K Benzamides %K Child %K Child, Preschool %K Disease-Free Survival %K Drug Administration Schedule %K Female %K Fusion Proteins, bcr-abl %K Graft vs Host Disease %K Hematopoietic Stem Cell Transplantation %K Humans %K Infant %K Italy %K Male %K Philadelphia Chromosome %K Piperazines %K Precursor Cell Lymphoblastic Leukemia-Lymphoma %K Pyrimidines %K Remission Induction %K Retrospective Studies %K Secondary Prevention %K Transplantation, Homologous %K Young Adult %X

Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL) still represents a major challenge. We report the experience of the Italian Association of Pediatric Hematology and Oncology (AIEOP) with allogeneic hematopoietic stem cell transplantation (HSCT) in children with Ph+ ALL from 1990 to 2008. Sixty-nine patients received HSCT from either a related (37, 54%) or an unrelated (32, 46%) donor. Twenty-five patients (36%) underwent transplantation before 2000 and 44 (64%) after 2000. Twenty-three patients (33%) received Imatinib mesylate treatment before HSCT and seven (10%) after HSCT. After a median follow-up of 56 months, the overall survival (OS) probability was 51% (95% confidence interval [CI], 38-63), the leukemia-free survival (LFS) was 47% (95% CI, 34-59), transplantation-related mortality (TRM) was 17% (95% CI, 10-30), and relapse incidence (RI) was 36% (95% CI, 26-50). Transplantation in first complete remission, female gender, and lower WBC count at diagnosis were associated with a better LFS in both univariate and multivariate analyses. Patients with p210 transcript had a trend for a worse prognosis compared with those who had the p190 transcript. Our series confirms the role of HSCT in the eradication of Ph+ ALL. Early HSCT is recommended once morphologic remission is obtained.

%B Biol Blood Marrow Transplant %V 18 %P 852-60 %8 2012 Jun %G eng %N 6 %1 http://www.ncbi.nlm.nih.gov/pubmed/22019726?dopt=Abstract %R 10.1016/j.bbmt.2011.10.015