%0 Journal Article %J Nat Genet %D 2012 %T Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations. %A Okada, Yukinori %A Sim, Xueling %A Go, Min Jin %A Wu, Jer-Yuarn %A Gu, Dongfeng %A Takeuchi, Fumihiko %A Takahashi, Atsushi %A Maeda, Shiro %A Tsunoda, Tatsuhiko %A Chen, Peng %A Lim, Su-Chi %A Wong, Tien-Yin %A Liu, Jianjun %A Young, Terri L %A Aung, Tin %A Seielstad, Mark %A Teo, Yik-Ying %A Kim, Young Jin %A Lee, Jong-Young %A Han, Bok-Ghee %A Kang, Daehee %A Chen, Chien-Hsiun %A Tsai, Fuu-Jen %A Chang, Li-Ching %A Fann, S-J Cathy %A Mei, Hao %A Rao, Dabeeru C %A Hixson, James E %A Chen, Shufeng %A Katsuya, Tomohiro %A Isono, Masato %A Ogihara, Toshio %A Chambers, John C %A Zhang, Weihua %A Kooner, Jaspal S %A Albrecht, Eva %A Yamamoto, Kazuhiko %A Kubo, Michiaki %A Nakamura, Yusuke %A Kamatani, Naoyuki %A Kato, Norihiro %A He, Jiang %A Chen, Yuan-Tsong %A Cho, Yoon Shin %A Tai, E-Shyong %A Tanaka, Toshihiro %K Asian Continental Ancestry Group %K Blood Urea Nitrogen %K Cohort Studies %K Creatinine %K Genetic Predisposition to Disease %K Genome-Wide Association Study %K Glomerular Filtration Rate %K Humans %K Kidney %K Polymorphism, Single Nucleotide %K Renal Insufficiency, Chronic %K Uric Acid %X

Chronic kidney disease (CKD), impairment of kidney function, is a serious public health problem, and the assessment of genetic factors influencing kidney function has substantial clinical relevance. Here, we report a meta-analysis of genome-wide association studies for kidney function-related traits, including 71,149 east Asian individuals from 18 studies in 11 population-, hospital- or family-based cohorts, conducted as part of the Asian Genetic Epidemiology Network (AGEN). Our meta-analysis identified 17 loci newly associated with kidney function-related traits, including the concentrations of blood urea nitrogen, uric acid and serum creatinine and estimated glomerular filtration rate based on serum creatinine levels (eGFRcrea) (P < 5.0 × 10(-8)). We further examined these loci with in silico replication in individuals of European ancestry from the KidneyGen, CKDGen and GUGC consortia, including a combined total of ∼110,347 individuals. We identify pleiotropic associations among these loci with kidney function-related traits and risk of CKD. These findings provide new insights into the genetics of kidney function.

%B Nat Genet %V 44 %P 904-9 %8 2012 Aug %G eng %N 8 %1 http://www.ncbi.nlm.nih.gov/pubmed/22797727?dopt=Abstract %R 10.1038/ng.2352