%0 Journal Article %J Eur J Clin Pharmacol %D 2014 %T Breastfeeding and migraine drugs. %A Davanzo, Riccardo %A Bua, Jenny %A Paloni, Giulia %A Facchina, Giulia %K Adrenergic beta-Antagonists %K Analgesics, Non-Narcotic %K Animals %K Anti-Inflammatory Agents, Non-Steroidal %K Anticonvulsants %K Antidepressive Agents %K Breast Feeding %K Calcium Channel Blockers %K Female %K Humans %K Migraine Disorders %K Tryptamines %X

PURPOSE: Breastfeeding women may suffer from migraine. While we have many drugs for its treatment and prophylaxis, the majority are poorly studied in breastfeeding women. We conducted a review of the most common anti-migraine drugs (AMDs) and we determined their lactation risk.

METHODS: For each AMD, we collected all retrievable data from Hale's Medications and Mother Milk (2012), from the LactMed database (2014) of the National Library of Medicine, and from a MedLine Search of relevant studies published in the last 10 years.

RESULTS: According to our review, AMDs safe during breastfeeding are as follows: low-dose acetylsalicylic acid (ASA), ibuprofen, sumatriptan, metoprolol, propranolol, verapamil, amitriptyline, escitalopram, paroxetine, sertraline, acetaminophen, caffeine, and metoclopramide. AMDs compatible with breastfeeding but warranting caution are as follows: diclofenac, ketoprofen, naproxen, most new triptans, topiramate, valproate, venlafaxine, and cyproheptadine. Finally, high-dose ASA, atenolol, nadolol, cinnarizine, flunarizine, ergotamine, methysergide, and pizotifen are contraindicated.

CONCLUSIONS: According to our review, the majority of the revised AMDs were assessed to be compatible with breastfeeding.

%B Eur J Clin Pharmacol %V 70 %P 1313-24 %8 2014 Nov %G eng %N 11 %1 http://www.ncbi.nlm.nih.gov/pubmed/25217187?dopt=Abstract %R 10.1007/s00228-014-1748-0