%0 Journal Article %J Arch Dis Child Fetal Neonatal Ed %D 2015 %T Cerebral oxygenation with different nasal continuous positive airway pressure levels in preterm infants. %A Bembich, Stefano %A Travan, Laura %A Cont, Gabriele %A Bua, Jenny %A Strajn, Tamara %A Demarini, Sergio %K Cerebrovascular Circulation %K Continuous Positive Airway Pressure %K Female %K Hemoglobins %K Humans %K Infant, Newborn %K Infant, Premature %K Intensive Care, Neonatal %K Male %K Nasal Cavity %K Oxygen %K Oxygen Consumption %K Oxyhemoglobins %K Spectroscopy, Near-Infrared %X

OBJECTIVES: This study evaluates the effect of varying nasal continuous positive airway pressure (NCPAP) level on cerebral blood flow (CBF) and oxygenation in preterm infants.

METHODS: Oxy-haemoglobin (HbO2) and total haemoglobin (HbTot), as CBF estimates, and the ratio between HbO2 and HbTot (HbO2/HbTot), as cerebral oxygenation estimate, were assessed by near-infrared spectroscopy in 26 stable preterm newborns at a postmenstrual age between 26 and 33 weeks. Baseline HbO2, HbTot and HbO2/HbTot values were initially collected with NCPAP at 5 cm H2O and then compared with values obtained with NCPAP levels at both 3 and 8 cm H2O.

RESULTS: Compared with 5 cm H2O, cerebral HbO2, HbTot and HbO2/HbTot remained unchanged both after increasing (to 8 cm H2O) and decreasing (to 3 cm H2O) the NCPAP level. This result was observed both in regional areas (24 sites) and in the overall monitored area (frontal and parietal cortex). Compared with 8 cm H2O, peripheral oxygen saturation significantly decreased at 3 cm H2O (p=0.021). Heart rate did not change.

CONCLUSIONS: No differences in CBF and cerebral oxygenation were observed with NCPAP levels in the range 3-8 cm H2O despite a decrease in peripheral oxygenation with 3 cm H2O.

%B Arch Dis Child Fetal Neonatal Ed %V 100 %P F165-8 %8 2015 Mar %G eng %N 2 %1 http://www.ncbi.nlm.nih.gov/pubmed/25336677?dopt=Abstract %R 10.1136/archdischild-2014-306356