%0 Journal Article %J Ital J Pediatr %D 2017 %T Safety and effectiveness of oral propranolol for infantile hemangiomas started before 5 weeks and after 5 months of age: an Italian multicenter experience. %A El Hachem, Maya %A Gesualdo, Francesco %A Diociaiuti, Andrea %A Berti, Irene %A Vercellino, Nadia %A Boccaletti, Valeria %A Neri, Iria %A Porcedda, Giulio %A Greco, Antonella %A Carnevale, Claudia %A Oranges, Teresa %A Cutrone, Mario %A Dalmonte, Pietro %K Administration, Oral %K Age Factors %K Cohort Studies %K Dose-Response Relationship, Drug %K Drug Administration Schedule %K Female %K Hemangioma %K Humans %K Infant %K Infant, Newborn %K Italy %K Male %K Patient Safety %K Propranolol %K Retrospective Studies %K Skin Neoplasms %K Treatment Outcome %X

BACKGROUND: Despite not being licensed for the treatment of infantile hemangiomas (IH) in infants younger than 5 weeks or older than 5 months, propranolol is often used in these age groups to prevent or to treat potentially severe complications. The objective of the present study was to review the experience of 8 Italian pediatric and dermatologic centers regarding propranolol treatment for IH started before 5 weeks or after 5 months of age.

METHODS: We retrospectively reviewed the records of patients followed up for IH, on propranolol treatment started before 5 weeks or after 5 months of age, and collected information on sociodemographic data, treatment indications, IH involution, IH relapse, and treatment side effects.

RESULTS: A total of 343 patients were enrolled; 15 were started on propranolol before 5 weeks (group 1), 328 were started after 5 months of age (group 2). The most frequent indications were permanent aesthetical disfigurement (91.8%) and function threatening complications (42.6%). In most cases, the treatment was effective. The involution was partial in 67.7% of patients. In 11.8% of cases a relapse was observed. No relapse was observed in group 1. Treatment complications were reported in 15.8% of children, most frequently sleep disorders (6.6%), followed by irritability (5.1%) and diarrhea (2.2%). Only a case of mild constipation was observed in group 1.

CONCLUSION: The safety and effectiveness profile of propranolol in infants younger than 5 weeks or older than 5 months may be acceptable. Taking in account propranolol's potential in preventing severe complications, further studies should assess the acceptability of propranolol treatment, especially in the <5-week age group .

%B Ital J Pediatr %V 43 %P 40 %8 2017 Apr 19 %G eng %N 1 %1 http://www.ncbi.nlm.nih.gov/pubmed/28424095?dopt=Abstract %R 10.1186/s13052-017-0357-9 %0 Journal Article %J Ital J Pediatr %D 2016 %T Consensus Conference on Clinical Management of pediatric Atopic Dermatitis. %A Galli, Elena %A Neri, Iria %A Ricci, Giampaolo %A Baldo, Ermanno %A Barone, Maurizio %A Belloni Fortina, Anna %A Bernardini, Roberto %A Berti, Irene %A Caffarelli, Carlo %A Calamelli, Elisabetta %A Capra, Lucetta %A Carello, Rossella %A Cipriani, Francesca %A Comberiati, Pasquale %A Diociaiuti, Andrea %A El Hachem, Maya %A Fontana, Elena %A Gruber, Michaela %A Haddock, Ellen %A Maiello, Nunzia %A Meglio, Paolo %A Patrizi, Annalisa %A Peroni, Diego %A Scarponi, Dorella %A Wielander, Ingrid %A Eichenfield, Lawrence F %X

The Italian Consensus Conference on clinical management of atopic dermatitis in children reflects the best and most recent scientific evidence, with the aim to provide specialists with a useful tool for managing this common, but complex clinical condition. Thanks to the contribution of experts in the field and members of the Italian Society of Pediatric Allergology and Immunology (SIAIP) and the Italian Society of Pediatric Dermatology (SIDerP), this Consensus statement integrates the basic principles of the most recent guidelines for the management of atopic dermatitis to facilitate a practical approach to the disease. The therapeutical approach should be adapted to the clinical severity and requires a tailored strategy to ensure good compliance by children and their parents. In this Consensus, levels and models of intervention are also enriched by the Italian experience to facilitate a practical approach to the disease.

%B Ital J Pediatr %V 42 %P 26 %8 2016 %G eng %1 http://www.ncbi.nlm.nih.gov/pubmed/26936273?dopt=Abstract %R 10.1186/s13052-016-0229-8