%0 Journal Article %J J Med Virol %D 2011 %T High prevalence of BK polyomavirus sequences in human papillomavirus-16-positive precancerous cervical lesions. %A Comar, Manola %A Bonifacio, Daniela %A Zanconati, Fabrizio %A Di Napoli, Michela %A Isidoro, Erica %A Martini, Fernanda %A Torelli, Lucio %A Tognon, Mauro %K Adult %K BK Virus %K Cervical Intraepithelial Neoplasia %K Cervix Uteri %K DNA, Viral %K Female %K Human papillomavirus 16 %K Human papillomavirus 18 %K Human papillomavirus 31 %K Humans %K JC Virus %K Middle Aged %K Oncogene Proteins, Viral %K Papillomavirus Infections %K Precancerous Conditions %K Simian virus 40 %K Uterine Cervical Diseases %X

High- and low-grade cervical lesions were analyzed for the presence of polyomavirus (PYV) and human papillomavirus (HPV) sequences. In precancerous cervical lesions, the overall prevalence of PYV sequences was 44% (41/93). Specifically, among the PYV-positive samples, 83% (34/41) tested positive for BK polyomavirus (BKV) sequences, whereas 17% (7/41) were positive for JC-virus. None of the samples were positive for simian virus 40. The presence of BKV DNA in high-grade squamous intraepithelial lesions was confirmed by in situ PCR. BKV sequences were detected more frequently in high-grade squamous intraepithelial lesions, together with the genotype HPV-16. The association of BKV with precancerous cervical lesions suggests that this polyomavirus participates with HPV-16 in the cell transformation process. Alternatively, BKV might multiply better in HPV-16-positive cells from precancerous cervical lesions than in HPV-16-negative cells.

%B J Med Virol %V 83 %P 1770-6 %8 2011 Oct %G eng %N 10 %1 http://www.ncbi.nlm.nih.gov/pubmed/21837794?dopt=Abstract %R 10.1002/jmv.22184