%0 Journal Article %J Mediators Inflamm %D 2014 %T Association of serum tumor necrosis factor-related apoptosis inducing ligand with body fat distribution as assessed by dual X-rays absorptiometry. %A Cervellati, Carlo %A Secchiero, Paola %A Bonaccorsi, Gloria %A Celeghini, Claudio %A Zauli, Giorgio %K Absorptiometry, Photon %K Adipose Tissue %K Adiposity %K Adult %K Anthropometry %K Female %K Gene Expression Regulation %K Humans %K Inflammation %K Linear Models %K Menopause %K Middle Aged %K Overweight %K TNF-Related Apoptosis-Inducing Ligand %X

A low chronic inflammation mediated by cytokine release is considered a major pathogenic mechanism accounting for the higher risk of cardiovascular disease in the overweight/obese population. In this context, although the existence of a possible interaction between soluble tumor necrosis factor- (TNF-) related apoptosis inducing ligand (TRAIL) and quantity and localization, of adiposity in the body has been hypothesized, no studies have yet investigated this link by radiologic techniques able to assess directly fat mass (FM) in different body regions. To address this issue, we assessed body fat distribution by dual X-rays absorptiometry (DXA) in a sample of 103 women and investigated the possible association between the derived adiposity measures and serum TRAIL concentration. The level of TRAIL showed a positive and independent correlation with arms FM (P < 0.05), trunk FM (P < 0.001) and trunk FM% (P < 0.05), total FM and total FM% (P < 0.001 for both), and an inverse association with legs FM% (P < 0.05). Only trunk FM retained a significant correlation (P < 0.05) with TRAIL after adjusting for all the other indices of regional adiposity. In conclusion, from our study it emerged a significant and independent association of serum TRAIL levels with overall, and, mainly, central adiposity. Further studies are needed to longitudinally investigate the cause-effect relationship between change in body fat distribution and TRAIL.

%B Mediators Inflamm %V 2014 %P 306848 %8 2014 %G eng %1 http://www.ncbi.nlm.nih.gov/pubmed/24966465?dopt=Abstract %R 10.1155/2014/306848 %0 Journal Article %J J Clin Endocrinol Metab %D 2014 %T Inverse correlation between circulating levels of TNF-related apoptosis-inducing ligand and 17β-estradiol. %A Zauli, Giorgio %A Tisato, Veronica %A Melloni, Elisabetta %A Volpato, Stefano %A Cervellati, Carlo %A Bonaccorsi, Gloria %A Radillo, Oriano %A Marci, Roberto %A Secchiero, Paola %K Adult %K Aged %K Case-Control Studies %K Child %K Child, Preschool %K Estradiol %K Female %K Humans %K Infant %K Male %K Middle Aged %K Pregnancy %K Sex Factors %K TNF-Related Apoptosis-Inducing Ligand %K Young Adult %X

CONTEXT: The regulation of the circulating levels of TNF-related apoptosis-inducing ligand (TRAIL), a cytokine of the TNF family, playing a key role in the immune surveillance against cancer, is incompletely understood.

OBJECTIVE: The objective of the study was to investigate the potential link between TRAIL and 17β-estradiol.

DESIGN, SETTING, AND PARTICIPANTS: Circulating TRAIL levels were measured by an ELISA in plasma samples (n = 246) of healthy, age-matched (range 30-70 y) men and women and in the sera (n = 180) of females belonging to different physiopathological conditions (childhood, pregnancy, under gonadotropin treatment, menopause) characterized by different levels of circulating 17β-estradiol.

RESULTS: TRAIL plasma levels in women with aged younger than 50 years were significantly lower compared with age-matched men, whereas in woman 50 years old or older, TRAIL levels were significantly higher compared with the age-matched men and with the younger women. Moreover, an analysis of women with different conditions revealed a significant inverse correlation between the serum levels of TRAIL and 17β-estradiol, with the lowest levels of TRAIL being observed during pregnancy and the highest in childhood and in postmenopausal women. Moreover, gonadotropin treatment in women undergoing assisted reproduction was accompanied by an acute decrease of serum TRAIL levels. Finally, in vitro treatment with 17β-estradiol decreased the TRAIL expression levels in peripheral blood mononuclear cells.

CONCLUSIONS: Our data suggest that 17β-estradiol plays a role in regulating TRAIL circulating levels. The demonstration that postmenopausal women exhibit the highest TRAIL levels is of particular interest in light of a previous large study population showing that TRAIL is positively correlated to the overall survival.

%B J Clin Endocrinol Metab %V 99 %P E659-64 %8 2014 Apr %G eng %N 4 %1 http://www.ncbi.nlm.nih.gov/pubmed/24446659?dopt=Abstract %R 10.1210/jc.2013-4193