%0 Journal Article %J Tissue Antigens %D 2014 %T HLA-G gene polymorphisms associated with susceptibility to rheumatoid arthritis disease and its severity in Brazilian patients. %A Catamo, E %A Addobbati, C %A Segat, L %A Sotero Fragoso, T %A Domingues Barbosa, A %A Tavares Dantas, A %A de AtaĆ­de Mariz, H %A F da Rocha, L %A Branco Pinto Duarte, A L %A Monasta, L %A Sandrin-Garcia, P %A Crovella, S %K 3' Untranslated Regions %K 5' Flanking Region %K Aged %K Arthritis, Rheumatoid %K Brazil %K Disease Progression %K DNA Mutational Analysis %K Female %K Gene Frequency %K Genetic Association Studies %K Genetic Predisposition to Disease %K Genotype %K Haplotypes %K HLA-G Antigens %K Humans %K Male %K Middle Aged %K Polymorphism, Single Nucleotide %K Risk %X

We analyzed the possible association between human leukocyte antigen-G (HLA-G) genetic variants, supposed to regulate HLA-G expression, and the susceptibility to develop rheumatoid arthritis (RA) as well as its clinical manifestations. The 5'upstream regulatory region (5'URR) and 3'untranslated region (3'UTR) regions of the HLA-G gene were screened in 127 RA patients and 128 controls: 10 5'URR and 3 3'UTR HLA-G polymorphisms as well as two haplotypes were associated with risk for RA development, while a polymorphism in the 5'URR showed an association with the degree of disease activity. These findings, although the number of cases analyzed is limited and the P-values are modest, indicate a possible association between HLA-G gene polymorphisms and susceptibility to develop RA disease and its severity.

%B Tissue Antigens %V 84 %P 308-15 %8 2014 Sep %G eng %N 3 %1 http://www.ncbi.nlm.nih.gov/pubmed/24957665?dopt=Abstract %R 10.1111/tan.12396