%0 Journal Article %J Tissue Antigens %D 2015 %T Comprehensive analysis of polymorphisms in the HLA-G 5' upstream regulatory and 3' untranslated regions in Brazilian patients with systemic lupus erythematosus. %A Catamo, E %A Addobbati, C %A Segat, L %A Sotero Fragoso, T %A Tavares Dantas, A %A de Ataíde Mariz, H %A Ferreira da Rocha Junior, L %A Branco PintoDuarte, A L %A Coelho, A V C %A de Moura, R R %A Polesello, V %A Crovella, S %A Sandrin Garcia, P %X

This study aims to comprehensively analyze human leucocyte antigen (HLA)-G polymorphisms association with susceptibility to systemic lupus erythematosus (SLE) development and clinical manifestations. The HLA-G 5' upstream regulatory region (URR), 3' untranslated region (UTR) and a cytosine deletion at exon 3 (ΔC, HLA-G*0105N allele) were analyzed in 114 SLE patients and 128 healthy controls from North East Brazil. The +3003T>C (rs1707) C allele and the HG010101c extended HLA-G allele were significantly more frequent in SLE patients than healthy controls (+3003C allele frequency: 12% in SLE patients vs 6% in controls; odds ratio (OR), 2.10, 95% confidence interval (CI), 1.06-4.28, P = 0.026; HG010101c frequency: 11.8% in SLE patients and 6.3% in controls; OR, 2.14, 95% CI, 1.01-4.51, P = 0.046) and were associated with susceptibility for disease development. Other polymorphisms were associated with different clinical manifestations. Although HLA-G role in SLE disease is far from being elucidated yet, our association study results along with a systematic review and meta-analysis suggest that HLA-G might be able to slightly modulate the complex SLE phenotype (pooled OR, 1.14, 95% CI, 1.02-1.27, P = 0.021).

%B Tissue Antigens %V 85 %P 458-65 %8 2015 Jun %G eng %N 6 %1 http://www.ncbi.nlm.nih.gov/pubmed/25762019?dopt=Abstract %R 10.1111/tan.12545 %0 Journal Article %J Tissue Antigens %D 2014 %T HLA-G gene polymorphisms associated with susceptibility to rheumatoid arthritis disease and its severity in Brazilian patients. %A Catamo, E %A Addobbati, C %A Segat, L %A Sotero Fragoso, T %A Domingues Barbosa, A %A Tavares Dantas, A %A de Ataíde Mariz, H %A F da Rocha, L %A Branco Pinto Duarte, A L %A Monasta, L %A Sandrin-Garcia, P %A Crovella, S %K 3' Untranslated Regions %K 5' Flanking Region %K Aged %K Arthritis, Rheumatoid %K Brazil %K Disease Progression %K DNA Mutational Analysis %K Female %K Gene Frequency %K Genetic Association Studies %K Genetic Predisposition to Disease %K Genotype %K Haplotypes %K HLA-G Antigens %K Humans %K Male %K Middle Aged %K Polymorphism, Single Nucleotide %K Risk %X

We analyzed the possible association between human leukocyte antigen-G (HLA-G) genetic variants, supposed to regulate HLA-G expression, and the susceptibility to develop rheumatoid arthritis (RA) as well as its clinical manifestations. The 5'upstream regulatory region (5'URR) and 3'untranslated region (3'UTR) regions of the HLA-G gene were screened in 127 RA patients and 128 controls: 10 5'URR and 3 3'UTR HLA-G polymorphisms as well as two haplotypes were associated with risk for RA development, while a polymorphism in the 5'URR showed an association with the degree of disease activity. These findings, although the number of cases analyzed is limited and the P-values are modest, indicate a possible association between HLA-G gene polymorphisms and susceptibility to develop RA disease and its severity.

%B Tissue Antigens %V 84 %P 308-15 %8 2014 Sep %G eng %N 3 %1 http://www.ncbi.nlm.nih.gov/pubmed/24957665?dopt=Abstract %R 10.1111/tan.12396