%0 Journal Article %J Blood Transfus %D 2017 %T Diagnosis and management of newly diagnosed childhood autoimmune haemolytic anaemia. Recommendations from the Red Cell Study Group of the Paediatric Haemato-Oncology Italian Association. %A Ladogana, Saverio %A Maruzzi, Matteo %A Samperi, Piera %A Perrotta, Silverio %A Del Vecchio, Giovanni C %A Notarangelo, Lucia D %A Farruggia, Piero %A Verzegnassi, Federico %A Masera, Nicoletta %A Saracco, Paola %A Fasoli, Silvia %A Miano, Maurizio %A Girelli, Gabriella %A Barcellini, Wilma %A Zanella, Alberto %A Russo, Giovanna %K Anemia, Hemolytic, Autoimmune %K Blood Transfusion %K Child %K Coombs Test %K Disease Management %K Hematology %K Humans %K Immunoglobulin M %K Italy %K Pediatrics %K Societies, Medical %K Steroids %X

Autoimmune haemolytic anaemia is an uncommon disorder to which paediatric haematology centres take a variety of diagnostic and therapeutic approaches. The Red Cell Working Group of the Italian Association of Paediatric Onco-haematology (Associazione Italiana di Ematologia ed Oncologia Pediatrica, AIEOP) developed this document in order to collate expert opinions on the management of newly diagnosed childhood autoimmune haemolytic anaemia.The diagnostic process includes the direct and indirect antiglobulin tests; recommendations are given regarding further diagnostic tests, specifically in the cases that the direct and indirect antiglobulin tests are negative. Clear-cut definitions of clinical response are stated. Specific recommendations for treatment include: dosage of steroid therapy and tapering modality for warm autoimmune haemolytic anaemia; the choice of rituximab as first-line therapy for the rare primary transfusion-dependent cold autoimmune haemolytic anaemia; the indications for supportive therapy; the need for switching to second-line therapy. Each statement is provided with a score expressing the level of appropriateness and the agreement among participants.

%B Blood Transfus %V 15 %P 259-267 %8 2017 May %G eng %N 3 %1 http://www.ncbi.nlm.nih.gov/pubmed/28151390?dopt=Abstract %R 10.2450/2016.0072-16 %0 Journal Article %J Ann Hematol %D 2015 %T Recommendations for the use of long-term central venous catheter (CVC) in children with hemato-oncological disorders: management of CVC-related occlusion and CVC-related thrombosis. On behalf of the coagulation defects working group and the supportive the %A Giordano, Paola %A Saracco, Paola %A Grassi, Massimo %A Luciani, Matteo %A Banov, Laura %A Carraro, Francesca %A Crocoli, Alessandro %A Cesaro, Simone %A Zanazzo, Giulio Andrea %A Molinari, Angelo Claudio %K Adult %K Blood Coagulation Disorders %K Catheter Obstruction %K Catheterization, Central Venous %K Central Venous Catheters %K Child %K Hematologic Neoplasms %K Humans %K Risk Factors %K Thrombosis %X

Central venous catheters (CVC), used for the management of children with hemato-oncological disorders, are burdened by a significant incidence of mechanical, infective, or thrombotic complications. These complications favor an increasing risk in prolongation of hospitalization, extra costs of care, and sometimes severe life-threatening events. No guidelines for the management of CVC-related occlusion and CVC-related thrombosis are available for children. To this aim, members of the coagulation defects working group and the supportive therapy working group of the Italian Association of Pediatric Hematology and Oncology (AIEOP) reviewed the pediatric and adult literature to propose the first recommendations for the management of CVC-related occlusion and CVC-related thrombosis in children with hemato-oncological disorders.

%B Ann Hematol %V 94 %P 1765-76 %8 2015 Nov %G eng %N 11 %1 http://www.ncbi.nlm.nih.gov/pubmed/26300457?dopt=Abstract %R 10.1007/s00277-015-2481-1