%0 Journal Article %J Int J Immunogenet %D 2016 %T Association of the HLA-G 3'UTR polymorphisms with colorectal cancer in Italy: a first insight. %A Garziera, M %A Catamo, E %A Crovella, S %A Montico, M %A Cecchin, E %A Lonardi, S %A Mini, E %A Nobili, S %A Romanato, L %A Toffoli, G %X

This study aimed to explore functional and regulatory polymorphisms and haplotypes at the HLA-G 3'UTR region in colorectal cancer development. The presence of nonpolymorphic variants was also evaluated. Three-hundred and eight patients with colorectal cancer and 294 healthy controls were analysed at the germinal level. We found an association with increased risk of colorectal cancer for +2960 14-bp INDEL, +3196 C>G SNPs and UTR-2 haplotype, and a 'protective' role for +3003 T>C, +3010 C>G polymorphisms and UTR-4 haplotype. We detected in 3 distinct patients, a novel nucleotide change (+3037 C>A) and 2 already described rare variants, +3032 G/C (EUR MAF = 0.1%) and +3092 G/T (EUR MAF = 0%). This is the first study showing associations between different polymorphisms in the HLA-G 3'UTR and colorectal cancer susceptibility.

%B Int J Immunogenet %V 43 %P 32-9 %8 2016 Feb %G eng %N 1 %1 http://www.ncbi.nlm.nih.gov/pubmed/26752414?dopt=Abstract %R 10.1111/iji.12243