%0 Journal Article %J Ann Rheum Dis %D 2010 %T EULAR/PRINTO/PRES criteria for Henoch-Schönlein purpura, childhood polyarteritis nodosa, childhood Wegener granulomatosis and childhood Takayasu arteritis: Ankara 2008. Part I: Overall methodology and clinical characterisation. %A Ruperto, Nicolino %A Ozen, Seza %A Pistorio, Angela %A Dolezalova, Pavla %A Brogan, Paul %A Cabral, David A %A Cuttica, Ruben %A Khubchandani, Raju %A Lovell, Daniel J %A O'Neil, Kathleen M %A Quartier, Pierre %A Ravelli, Angelo %A Iusan, Silvia M %A Filocamo, Giovanni %A Magalhães, Claudia Saad %A Unsal, Erbil %A Oliveira, Sheila %A Bracaglia, Claudia %A Bagga, Arvind %A Stanevicha, Valda %A Manzoni, Silvia Magni %A Pratsidou, Polyxeni %A Lepore, Loredana %A Espada, Graciela %A Kone-Paut, Isabella %A Paut, Isabelle Kone %A Zulian, Francesco %A Barone, Patrizia %A Bircan, Zelal %A Maldonado, Maria del Rocio %A Russo, Ricardo %A Vilca, Iris %A Tullus, Kjell %A Cimaz, Rolando %A Horneff, Gerd %A Anton, Jordi %A Garay, Stella %A Nielsen, Susan %A Barbano, Giancarlo %A Martini, Alberto %K Adolescent %K Biopsy %K Child %K Delphi Technique %K Granulomatosis with Polyangiitis %K Humans %K International Cooperation %K Internet %K Polyarteritis Nodosa %K Purpura, Schoenlein-Henoch %K Reproducibility of Results %K Takayasu Arteritis %X

OBJECTIVES: To report methodology and overall clinical, laboratory and radiographic characteristics for Henoch-Schönlein purpura (HSP), childhood polyarteritis nodosa (c-PAN), c-Wegener granulomatosis (c-WG) and c-Takayasu arteritis (c-TA) classification criteria.

METHODS: The preliminary Vienna 2005 consensus conference, which proposed preliminary criteria for paediatric vasculitides, was followed by a EULAR/PRINTO/PRES - supported validation project divided into three main steps. Step 1: retrospective/prospective web-data collection for HSP, c-PAN, c-WG and c-TA, with age at diagnosis

RESULTS: A total of 1183/1398 (85%) samples collected were available for analysis: 827 HSP, 150 c-PAN, 60 c-WG, 87 c-TA and 59 c-other. Prevalence, signs/symptoms, laboratory, biopsy and imaging reports were consistent with the clinical picture of the four c-vasculitides. A representative subgroup of 280 patients was blinded to the treating physician diagnosis and classified by a consensus panel, with a kappa-agreement of 0.96 for HSP (95% CI 0.84 to 1), 0.88 for c-WG (95% CI 0.76 to 0.99), 0.84 for c-TA (95% CI 0.73 to 0.96) and 0.73 for c-PAN (95% CI 0.62 to 0.84), with an overall kappa of 0.79 (95% CI 0.73 to 0.84).

CONCLUSION: EULAR/PRINTO/PRES propose validated classification criteria for HSP, c-PAN, c-WG and c-TA, with substantial/almost perfect agreement with the final consensus classification or original treating physician diagnosis.

%B Ann Rheum Dis %V 69 %P 790-7 %8 2010 May %G eng %N 5 %1 http://www.ncbi.nlm.nih.gov/pubmed/20388738?dopt=Abstract %R 10.1136/ard.2009.116624 %0 Journal Article %J Ann Rheum Dis %D 2010 %T Predictors of poor response to methotrexate in polyarticular-course juvenile idiopathic arthritis: analysis of the PRINTO methotrexate trial. %A Vilca, Iris %A Munitis, Pablo Garcia %A Pistorio, Angela %A Ravelli, Angelo %A Buoncompagni, Antonella %A Bica, Blanca %A Campos, Lucia %A Häfner, Renate %A Hofer, Michael %A Ozen, Seza %A Huemer, Christian %A Bae, Sang Cheol %A Sztajnbok, Flavio %A Arguedas, Olga %A Foeldvari, Ivan %A Huppertz, Hans Iko %A Gamir, María Luz %A Magnusson, Bo %A Dressler, Frank %A Uziel, Yosef %A van Rossum, Marion A J %A Hollingworth, Peter %A Cawkwell, Gail %A Martini, Alberto %A Ruperto, Nicolino %K Adolescent %K Antibodies, Antinuclear %K Antirheumatic Agents %K Arthritis, Juvenile %K Child %K Child, Preschool %K Disability Evaluation %K Female %K Follow-Up Studies %K Humans %K Immunosuppressive Agents %K Male %K Methotrexate %K Prognosis %K Treatment Outcome %X

OBJECTIVES: To determine whether baseline demographic, clinical, articular and laboratory variables predict methotrexate (MTX) poor response in polyarticular-course juvenile idiopathic arthritis.

METHODS: Patients newly treated for 6 months with MTX enrolled in the Paediatric Rheumatology International Trials Organization (PRINTO) MTX trial. Bivariate and logistic regression analyses were used to identify baseline predictors of poor response according to the American College of Rheumatology pediatric (ACR-ped) 30 and 70 criteria.

RESULTS: In all, 405/563 (71.9%) of patients were women; median age at onset and disease duration were 4.3 and 1.4 years, respectively, with anti-nuclear antibody (ANA) detected in 259/537 (48.2%) patients. With multivariate logistic regression analysis, the most important determinants of ACR-ped 70 non-responders were: disease duration > 1.3 years (OR 1.93), ANA negativity (OR 1.77), Childhood Health Assessment Questionnaire (CHAQ) disability index > 1.125 (OR 1.65) and the presence of right and left wrist activity (OR 1.55). Predictors of ACR-ped 30 non-responders were: ANA negativity (OR 1.92), CHAQ disability index > 1.14 (OR 2.18) and a parent's evaluation of child's overall well-being < or = 4.69 (OR 2.2).

CONCLUSION: The subgroup of patients with longer disease duration, ANA negativity, higher disability and presence of wrist activity were significantly associated with a poorer response to a 6-month MTX course.

%B Ann Rheum Dis %V 69 %P 1479-83 %8 2010 Aug %G eng %N 8 %1 http://www.ncbi.nlm.nih.gov/pubmed/20525842?dopt=Abstract %R 10.1136/ard.2009.120840