%0 Journal Article %J J Rheumatol %D 2017 %T Predictors of Relapse after Discontinuing Systemic Treatment in Childhood Autoimmune Chronic Uveitis. %A Simonini, Gabriele %A Bracaglia, Claudia %A Cattalini, Marco %A Taddio, Andrea %A Brambilla, Alice %A de Libero, Cinzia %A Pires Marafon, Denise %A Caputo, Roberto %A Cimaz, Rolando %K Adolescent %K Antirheumatic Agents %K Autoimmune Diseases %K Child %K Child, Preschool %K Female %K Humans %K Male %K Predictive Value of Tests %K Recurrence %K Retrospective Studies %K Treatment Outcome %K Uveitis %K Withholding Treatment %X

OBJECTIVE: To identify clinical predictors of relapse in childhood autoimmune chronic uveitis after stopping systemic treatment.

METHODS: A retrospective, multicenter, cohort study.

RESULTS: Ninety-four children in remission, receiving no treatments and with at least a 6-month followup, were enrolled. A higher probability of maintaining remission after discontinuing treatment was shown in idiopathic compared with juvenile idiopathic arthritis uveitis (Mantel-Cox chi-square = 23.21) if inactivity had been obtained within 6 months from starting systemic treatment (Mantel-Cox chi-square = 24.17) and by antitumor necrosis factor-α treatment (Mantel-Cox chi-square = 6.43).

CONCLUSION: Type of disease, time, and type of systemic therapy to achieve inactivity predict different duration of uveitis remission after treatment withdrawal.

%B J Rheumatol %V 44 %P 822-826 %8 2017 06 %G eng %N 6 %1 http://www.ncbi.nlm.nih.gov/pubmed/28365583?dopt=Abstract %R 10.3899/jrheum.161336