%0 Journal Article %J Inflamm Bowel Dis %D 2017 %T Ocular Involvement in Children with Inflammatory Bowel Disease. %A Naviglio, Samuele %A Parentin, Fulvio %A Nider, Silvia %A Rassu, Nicolò %A Martelossi, Stefano %A Ventura, Alessandro %K Adolescent %K Child %K Child, Preschool %K Feces %K Female %K Humans %K Inflammatory Bowel Diseases %K Italy %K Leukocyte L1 Antigen Complex %K Male %K Remission Induction %K Uveitis %X

BACKGROUND: Data on ocular manifestations of inflammatory bowel disease (IBD) in children are limited. Some authors have reported a high prevalence of asymptomatic uveitis, yet the significance of these observations is unknown and there are no recommendations on which ophthalmologic follow-up should be offered.

METHODS: Children with IBD seen at a single referral center for pediatric gastroenterology were offered ophthalmologic evaluation as part of routine care for their disease. Ophthalmologic evaluation included review of ocular history as well as slit-lamp and fundoscopic examination. Medical records were also reviewed for previous ophthalmologic diagnoses or complaints.

RESULTS: Data from 94 children were included (52 boys; median age 13.4 yr). Forty-six patients had a diagnosis of Crohn's disease, 46 ulcerative colitis, and 2 IBD unclassified. Intestinal disease was in clinical remission in 70% of the patients; fecal calprotectin was elevated in 64%. One patient with Crohn's disease had a previous diagnosis of clinically manifest uveitis (overall uveitis prevalence: 1.06%; incidence rate: 0.3 per 100 patient-years). This patient was also the only one who was found to have asymptomatic uveitis at slit-lamp examination. A second patient had posterior subcapsular cataract associated with corticosteroid treatment. No signs of intraocular complications from previous unrecognized uveitis were observed in any patient.

CONCLUSIONS: Children with IBD may have asymptomatic uveitis, yet its prevalence seems lower than previously reported, and it was not found in children without a previous diagnosis of clinically manifest uveitis. No ocular complications from prior unrecognized uveitis were observed.

%B Inflamm Bowel Dis %V 23 %P 986-990 %8 2017 06 %G eng %N 6 %1 http://www.ncbi.nlm.nih.gov/pubmed/28328621?dopt=Abstract %R 10.1097/MIB.0000000000001079