%0 Journal Article %J Nat Genet %D 2018 %T Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. %A Lee, James J %A Wedow, Robbee %A Okbay, Aysu %A Kong, Edward %A Maghzian, Omeed %A Zacher, Meghan %A Nguyen-Viet, Tuan Anh %A Bowers, Peter %A Sidorenko, Julia %A Karlsson Linnér, Richard %A Fontana, Mark Alan %A Kundu, Tushar %A Lee, Chanwook %A Li, Hui %A Li, Ruoxi %A Royer, Rebecca %A Timshel, Pascal N %A Walters, Raymond K %A Willoughby, Emily A %A Yengo, Loic %A Alver, Maris %A Bao, Yanchun %A Clark, David W %A Day, Felix R %A Furlotte, Nicholas A %A Joshi, Peter K %A Kemper, Kathryn E %A Kleinman, Aaron %A Langenberg, Claudia %A Mägi, Reedik %A Trampush, Joey W %A Verma, Shefali Setia %A Wu, Yang %A Lam, Max %A Zhao, Jing Hua %A Zheng, Zhili %A Boardman, Jason D %A Campbell, Harry %A Freese, Jeremy %A Harris, Kathleen Mullan %A Hayward, Caroline %A Herd, Pamela %A Kumari, Meena %A Lencz, Todd %A Luan, Jian'an %A Malhotra, Anil K %A Metspalu, Andres %A Milani, Lili %A Ong, Ken K %A Perry, John R B %A Porteous, David J %A Ritchie, Marylyn D %A Smart, Melissa C %A Smith, Blair H %A Tung, Joyce Y %A Wareham, Nicholas J %A Wilson, James F %A Beauchamp, Jonathan P %A Conley, Dalton C %A Esko, Tõnu %A Lehrer, Steven F %A Magnusson, Patrik K E %A Oskarsson, Sven %A Pers, Tune H %A Robinson, Matthew R %A Thom, Kevin %A Watson, Chelsea %A Chabris, Christopher F %A Meyer, Michelle N %A Laibson, David I %A Yang, Jian %A Johannesson, Magnus %A Koellinger, Philipp D %A Turley, Patrick %A Visscher, Peter M %A Benjamin, Daniel J %A Cesarini, David %X

Here we conducted a large-scale genetic association analysis of educational attainment in a sample of approximately 1.1 million individuals and identify 1,271 independent genome-wide-significant SNPs. For the SNPs taken together, we found evidence of heterogeneous effects across environments. The SNPs implicate genes involved in brain-development processes and neuron-to-neuron communication. In a separate analysis of the X chromosome, we identify 10 independent genome-wide-significant SNPs and estimate a SNP heritability of around 0.3% in both men and women, consistent with partial dosage compensation. A joint (multi-phenotype) analysis of educational attainment and three related cognitive phenotypes generates polygenic scores that explain 11-13% of the variance in educational attainment and 7-10% of the variance in cognitive performance. This prediction accuracy substantially increases the utility of polygenic scores as tools in research.

%B Nat Genet %V 50 %P 1112-1121 %8 2018 Aug %G eng %N 8 %1 http://www.ncbi.nlm.nih.gov/pubmed/30038396?dopt=Abstract %R 10.1038/s41588-018-0147-3