%0 Journal Article %J Nature %D 2017 %T Rare and low-frequency coding variants alter human adult height. %A Marouli, Eirini %A Graff, Mariaelisa %A Medina-Gomez, Carolina %A Lo, Ken Sin %A Wood, Andrew R %A Kjaer, Troels R %A Fine, Rebecca S %A Lu, Yingchang %A Schurmann, Claudia %A Highland, Heather M %A Rüeger, Sina %A Thorleifsson, Gudmar %A Justice, Anne E %A Lamparter, David %A Stirrups, Kathleen E %A Turcot, Valérie %A Young, Kristin L %A Winkler, Thomas W %A Esko, Tõnu %A Karaderi, Tugce %A Locke, Adam E %A Masca, Nicholas G D %A Ng, Maggie C Y %A Mudgal, Poorva %A Rivas, Manuel A %A Vedantam, Sailaja %A Mahajan, Anubha %A Guo, Xiuqing %A Abecasis, Goncalo %A Aben, Katja K %A Adair, Linda S %A Alam, Dewan S %A Albrecht, Eva %A Allin, Kristine H %A Allison, Matthew %A Amouyel, Philippe %A Appel, Emil V %A Arveiler, Dominique %A Asselbergs, Folkert W %A Auer, Paul L %A Balkau, Beverley %A Banas, Bernhard %A Bang, Lia E %A Benn, Marianne %A Bergmann, Sven %A Bielak, Lawrence F %A Blüher, Matthias %A Boeing, Heiner %A Boerwinkle, Eric %A Böger, Carsten A %A Bonnycastle, Lori L %A Bork-Jensen, Jette %A Bots, Michiel L %A Bottinger, Erwin P %A Bowden, Donald W %A Brandslund, Ivan %A Breen, Gerome %A Brilliant, Murray H %A Broer, Linda %A Burt, Amber A %A Butterworth, Adam S %A Carey, David J %A Caulfield, Mark J %A Chambers, John C %A Chasman, Daniel I %A Chen, Yii-Der Ida %A Chowdhury, Rajiv %A Christensen, Cramer %A Chu, Audrey Y %A Cocca, Massimiliano %A Collins, Francis S %A Cook, James P %A Corley, Janie %A Galbany, Jordi Corominas %A Cox, Amanda J %A Cuellar-Partida, Gabriel %A Danesh, John %A Davies, Gail %A de Bakker, Paul I W %A de Borst, Gert J %A de Denus, Simon %A de Groot, Mark C H %A de Mutsert, Renée %A Deary, Ian J %A Dedoussis, George %A Demerath, Ellen W %A den Hollander, Anneke I %A Dennis, Joe G %A Di Angelantonio, Emanuele %A Drenos, Fotios %A Du, Mengmeng %A Dunning, Alison M %A Easton, Douglas F %A Ebeling, Tapani %A Edwards, Todd L %A Ellinor, Patrick T %A Elliott, Paul %A Evangelou, Evangelos %A Farmaki, Aliki-Eleni %A Faul, Jessica D %A Feitosa, Mary F %A Feng, Shuang %A Ferrannini, Ele %A Ferrario, Marco M %A Ferrières, Jean %A Florez, Jose C %A Ford, Ian %A Fornage, Myriam %A Franks, Paul W %A Frikke-Schmidt, Ruth %A Galesloot, Tessel E %A Gan, Wei %A Gandin, Ilaria %A Gasparini, Paolo %A Giedraitis, Vilmantas %A Giri, Ayush %A Girotto, Giorgia %A Gordon, Scott D %A Gordon-Larsen, Penny %A Gorski, Mathias %A Grarup, Niels %A Grove, Megan L %A Gudnason, Vilmundur %A Gustafsson, Stefan %A Hansen, Torben %A Harris, Kathleen Mullan %A Harris, Tamara B %A Hattersley, Andrew T %A Hayward, Caroline %A He, Liang %A Heid, Iris M %A Heikkilä, Kauko %A Helgeland, Øyvind %A Hernesniemi, Jussi %A Hewitt, Alex W %A Hocking, Lynne J %A Hollensted, Mette %A Holmen, Oddgeir L %A Hovingh, G Kees %A Howson, Joanna M M %A Hoyng, Carel B %A Huang, Paul L %A Hveem, Kristian %A Ikram, M Arfan %A Ingelsson, Erik %A Jackson, Anne U %A Jansson, Jan-Håkan %A Jarvik, Gail P %A Jensen, Gorm B %A Jhun, Min A %A Jia, Yucheng %A Jiang, Xuejuan %A Johansson, Stefan %A Jørgensen, Marit E %A Jørgensen, Torben %A Jousilahti, Pekka %A Jukema, J Wouter %A Kahali, Bratati %A Kahn, René S %A Kähönen, Mika %A Kamstrup, Pia R %A Kanoni, Stavroula %A Kaprio, Jaakko %A Karaleftheri, Maria %A Kardia, Sharon L R %A Karpe, Fredrik %A Kee, Frank %A Keeman, Renske %A Kiemeney, Lambertus A %A Kitajima, Hidetoshi %A Kluivers, Kirsten B %A Kocher, Thomas %A Komulainen, Pirjo %A Kontto, Jukka %A Kooner, Jaspal S %A Kooperberg, Charles %A Kovacs, Peter %A Kriebel, Jennifer %A Kuivaniemi, Helena %A Küry, Sébastien %A Kuusisto, Johanna %A La Bianca, Martina %A Laakso, Markku %A Lakka, Timo A %A Lange, Ethan M %A Lange, Leslie A %A Langefeld, Carl D %A Langenberg, Claudia %A Larson, Eric B %A Lee, I-Te %A Lehtimäki, Terho %A Lewis, Cora E %A Li, Huaixing %A Li, Jin %A Li-Gao, Ruifang %A Lin, Honghuang %A Lin, Li-An %A Lin, Xu %A Lind, Lars %A Lindström, Jaana %A Linneberg, Allan %A Liu, Yeheng %A Liu, Yongmei %A Lophatananon, Artitaya %A Luan, Jian'an %A Lubitz, Steven A %A Lyytikäinen, Leo-Pekka %A Mackey, David A %A Madden, Pamela A F %A Manning, Alisa K %A Männistö, Satu %A Marenne, Gaëlle %A Marten, Jonathan %A Martin, Nicholas G %A Mazul, Angela L %A Meidtner, Karina %A Metspalu, Andres %A Mitchell, Paul %A Mohlke, Karen L %A Mook-Kanamori, Dennis O %A Morgan, Anna %A Morris, Andrew D %A Morris, Andrew P %A Müller-Nurasyid, Martina %A Munroe, Patricia B %A Nalls, Mike A %A Nauck, Matthias %A Nelson, Christopher P %A Neville, Matt %A Nielsen, Sune F %A Nikus, Kjell %A Njølstad, Pål R %A Nordestgaard, Børge G %A Ntalla, Ioanna %A O'Connel, Jeffrey R %A Oksa, Heikki %A Loohuis, Loes M Olde %A Ophoff, Roel A %A Owen, Katharine R %A Packard, Chris J %A Padmanabhan, Sandosh %A Palmer, Colin N A %A Pasterkamp, Gerard %A Patel, Aniruddh P %A Pattie, Alison %A Pedersen, Oluf %A Peissig, Peggy L %A Peloso, Gina M %A Pennell, Craig E %A Perola, Markus %A Perry, James A %A Perry, John R B %A Person, Thomas N %A Pirie, Ailith %A Polasek, Ozren %A Posthuma, Danielle %A Raitakari, Olli T %A Rasheed, Asif %A Rauramaa, Rainer %A Reilly, Dermot F %A Reiner, Alex P %A Renstrom, Frida %A Ridker, Paul M %A Rioux, John D %A Robertson, Neil %A Robino, Antonietta %A Rolandsson, Olov %A Rudan, Igor %A Ruth, Katherine S %A Saleheen, Danish %A Salomaa, Veikko %A Samani, Nilesh J %A Sandow, Kevin %A Sapkota, Yadav %A Sattar, Naveed %A Schmidt, Marjanka K %A Schreiner, Pamela J %A Schulze, Matthias B %A Scott, Robert A %A Segura-Lepe, Marcelo P %A Shah, Svati %A Sim, Xueling %A Sivapalaratnam, Suthesh %A Small, Kerrin S %A Smith, Albert Vernon %A Smith, Jennifer A %A Southam, Lorraine %A Spector, Timothy D %A Speliotes, Elizabeth K %A Starr, John M %A Steinthorsdottir, Valgerdur %A Stringham, Heather M %A Stumvoll, Michael %A Surendran, Praveen %A 't Hart, Leen M %A Tansey, Katherine E %A Tardif, Jean-Claude %A Taylor, Kent D %A Teumer, Alexander %A Thompson, Deborah J %A Thorsteinsdottir, Unnur %A Thuesen, Betina H %A Tönjes, Anke %A Tromp, Gerard %A Trompet, Stella %A Tsafantakis, Emmanouil %A Tuomilehto, Jaakko %A Tybjaerg-Hansen, Anne %A Tyrer, Jonathan P %A Uher, Rudolf %A Uitterlinden, André G %A Ulivi, Sheila %A van der Laan, Sander W %A Van Der Leij, Andries R %A van Duijn, Cornelia M %A van Schoor, Natasja M %A van Setten, Jessica %A Varbo, Anette %A Varga, Tibor V %A Varma, Rohit %A Edwards, Digna R Velez %A Vermeulen, Sita H %A Vestergaard, Henrik %A Vitart, Veronique %A Vogt, Thomas F %A Vozzi, Diego %A Walker, Mark %A Wang, Feijie %A Wang, Carol A %A Wang, Shuai %A Wang, Yiqin %A Wareham, Nicholas J %A Warren, Helen R %A Wessel, Jennifer %A Willems, Sara M %A Wilson, James G %A Witte, Daniel R %A Woods, Michael O %A Wu, Ying %A Yaghootkar, Hanieh %A Yao, Jie %A Yao, Pang %A Yerges-Armstrong, Laura M %A Young, Robin %A Zeggini, Eleftheria %A Zhan, Xiaowei %A Zhang, Weihua %A Zhao, Jing Hua %A Zhao, Wei %A Zhao, Wei %A Zheng, He %A Zhou, Wei %A Rotter, Jerome I %A Boehnke, Michael %A Kathiresan, Sekar %A McCarthy, Mark I %A Willer, Cristen J %A Stefansson, Kari %A Borecki, Ingrid B %A Liu, Dajiang J %A North, Kari E %A Heard-Costa, Nancy L %A Pers, Tune H %A Lindgren, Cecilia M %A Oxvig, Claus %A Kutalik, Zoltán %A Rivadeneira, Fernando %A Loos, Ruth J F %A Frayling, Timothy M %A Hirschhorn, Joel N %A Deloukas, Panos %A Lettre, Guillaume %K ADAMTS Proteins %K Adult %K Alleles %K Body Height %K Cell Adhesion Molecules %K Female %K Gene Frequency %K Genetic Variation %K Genome, Human %K Glycoproteins %K Glycosaminoglycans %K Hedgehog Proteins %K Humans %K Intercellular Signaling Peptides and Proteins %K Interferon Regulatory Factors %K Interleukin-11 Receptor alpha Subunit %K Male %K Multifactorial Inheritance %K NADPH Oxidase 4 %K NADPH Oxidases %K Phenotype %K Pregnancy-Associated Plasma Protein-A %K Procollagen N-Endopeptidase %K Proteoglycans %K Proteolysis %K Receptors, Androgen %K Somatomedins %X

Height is a highly heritable, classic polygenic trait with approximately 700 common associated variants identified through genome-wide association studies so far. Here, we report 83 height-associated coding variants with lower minor-allele frequencies (in the range of 0.1-4.8%) and effects of up to 2 centimetres per allele (such as those in IHH, STC2, AR and CRISPLD2), greater than ten times the average effect of common variants. In functional follow-up studies, rare height-increasing alleles of STC2 (giving an increase of 1-2 centimetres per allele) compromised proteolytic inhibition of PAPP-A and increased cleavage of IGFBP-4 in vitro, resulting in higher bioavailability of insulin-like growth factors. These 83 height-associated variants overlap genes that are mutated in monogenic growth disorders and highlight new biological candidates (such as ADAMTS3, IL11RA and NOX4) and pathways (such as proteoglycan and glycosaminoglycan synthesis) involved in growth. Our results demonstrate that sufficiently large sample sizes can uncover rare and low-frequency variants of moderate-to-large effect associated with polygenic human phenotypes, and that these variants implicate relevant genes and pathways.

%B Nature %V 542 %P 186-190 %8 2017 02 09 %G eng %N 7640 %1 http://www.ncbi.nlm.nih.gov/pubmed/28146470?dopt=Abstract %R 10.1038/nature21039 %0 Journal Article %J Nat Genet %D 2015 %T Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair. %A Day, Felix R %A Ruth, Katherine S %A Thompson, Deborah J %A Lunetta, Kathryn L %A Pervjakova, Natalia %A Chasman, Daniel I %A Stolk, Lisette %A Finucane, Hilary K %A Sulem, Patrick %A Bulik-Sullivan, Brendan %A Esko, Tõnu %A Johnson, Andrew D %A Elks, Cathy E %A Franceschini, Nora %A He, Chunyan %A Altmaier, Elisabeth %A Brody, Jennifer A %A Franke, Lude L %A Huffman, Jennifer E %A Keller, Margaux F %A McArdle, Patrick F %A Nutile, Teresa %A Porcu, Eleonora %A Robino, Antonietta %A Rose, Lynda M %A Schick, Ursula M %A Smith, Jennifer A %A Teumer, Alexander %A Traglia, Michela %A Vuckovic, Dragana %A Yao, Jie %A Zhao, Wei %A Albrecht, Eva %A Amin, Najaf %A Corre, Tanguy %A Hottenga, Jouke-Jan %A Mangino, Massimo %A Smith, Albert V %A Tanaka, Toshiko %A Abecasis, Goncalo R %A Andrulis, Irene L %A Anton-Culver, Hoda %A Antoniou, Antonis C %A Arndt, Volker %A Arnold, Alice M %A Barbieri, Caterina %A Beckmann, Matthias W %A Beeghly-Fadiel, Alicia %A Benitez, Javier %A Bernstein, Leslie %A Bielinski, Suzette J %A Blomqvist, Carl %A Boerwinkle, Eric %A Bogdanova, Natalia V %A Bojesen, Stig E %A Bolla, Manjeet K %A Borresen-Dale, Anne-Lise %A Boutin, Thibaud S %A Brauch, Hiltrud %A Brenner, Hermann %A Brüning, Thomas %A Burwinkel, Barbara %A Campbell, Archie %A Campbell, Harry %A Chanock, Stephen J %A Chapman, J Ross %A Chen, Yii-Der Ida %A Chenevix-Trench, Georgia %A Couch, Fergus J %A Coviello, Andrea D %A Cox, Angela %A Czene, Kamila %A Darabi, Hatef %A De Vivo, Immaculata %A Demerath, Ellen W %A Dennis, Joe %A Devilee, Peter %A Dörk, Thilo %A Dos-Santos-Silva, Isabel %A Dunning, Alison M %A Eicher, John D %A Fasching, Peter A %A Faul, Jessica D %A Figueroa, Jonine %A Flesch-Janys, Dieter %A Gandin, Ilaria %A Garcia, Melissa E %A García-Closas, Montserrat %A Giles, Graham G %A Girotto, Giorgia G %A Goldberg, Mark S %A González-Neira, Anna %A Goodarzi, Mark O %A Grove, Megan L %A Gudbjartsson, Daniel F %A Guenel, Pascal %A Guo, Xiuqing %A Haiman, Christopher A %A Hall, Per %A Hamann, Ute %A Henderson, Brian E %A Hocking, Lynne J %A Hofman, Albert %A Homuth, Georg %A Hooning, Maartje J %A Hopper, John L %A Hu, Frank B %A Huang, Jinyan %A Humphreys, Keith %A Hunter, David J %A Jakubowska, Anna %A Jones, Samuel E %A Kabisch, Maria %A Karasik, David %A Knight, Julia A %A Kolcic, Ivana %A Kooperberg, Charles %A Kosma, Veli-Matti %A Kriebel, Jennifer %A Kristensen, Vessela %A Lambrechts, Diether %A Langenberg, Claudia %A Li, Jingmei %A Li, Xin %A Lindström, Sara %A Liu, Yongmei %A Luan, Jian'an %A Lubinski, Jan %A Mägi, Reedik %A Mannermaa, Arto %A Manz, Judith %A Margolin, Sara %A Marten, Jonathan %A Martin, Nicholas G %A Masciullo, Corrado %A Meindl, Alfons %A Michailidou, Kyriaki %A Mihailov, Evelin %A Milani, Lili %A Milne, Roger L %A Müller-Nurasyid, Martina %A Nalls, Michael %A Neale, Benjamin M %A Nevanlinna, Heli %A Neven, Patrick %A Newman, Anne B %A Nordestgaard, Børge G %A Olson, Janet E %A Padmanabhan, Sandosh %A Peterlongo, Paolo %A Peters, Ulrike %A Petersmann, Astrid %A Peto, Julian %A Pharoah, Paul D P %A Pirastu, Nicola N %A Pirie, Ailith %A Pistis, Giorgio %A Polasek, Ozren %A Porteous, David %A Psaty, Bruce M %A Pylkäs, Katri %A Radice, Paolo %A Raffel, Leslie J %A Rivadeneira, Fernando %A Rudan, Igor %A Rudolph, Anja %A Ruggiero, Daniela %A Sala, Cinzia F %A Sanna, Serena %A Sawyer, Elinor J %A Schlessinger, David %A Schmidt, Marjanka K %A Schmidt, Frank %A Schmutzler, Rita K %A Schoemaker, Minouk J %A Scott, Robert A %A Seynaeve, Caroline M %A Simard, Jacques %A Sorice, Rossella %A Southey, Melissa C %A Stöckl, Doris %A Strauch, Konstantin %A Swerdlow, Anthony %A Taylor, Kent D %A Thorsteinsdottir, Unnur %A Toland, Amanda E %A Tomlinson, Ian %A Truong, Therese %A Tryggvadottir, Laufey %A Turner, Stephen T %A Vozzi, Diego %A Wang, Qin %A Wellons, Melissa %A Willemsen, Gonneke %A Wilson, James F %A Winqvist, Robert %A Wolffenbuttel, Bruce B H R %A Wright, Alan F %A Yannoukakos, Drakoulis %A Zemunik, Tatijana %A Zheng, Wei %A Zygmunt, Marek %A Bergmann, Sven %A Boomsma, Dorret I %A Buring, Julie E %A Ferrucci, Luigi %A Montgomery, Grant W %A Gudnason, Vilmundur %A Spector, Tim D %A van Duijn, Cornelia M %A Alizadeh, Behrooz Z %A Ciullo, Marina %A Crisponi, Laura %A Easton, Douglas F %A Gasparini, Paolo P %A Gieger, Christian %A Harris, Tamara B %A Hayward, Caroline %A Kardia, Sharon L R %A Kraft, Peter %A McKnight, Barbara %A Metspalu, Andres %A Morrison, Alanna C %A Reiner, Alex P %A Ridker, Paul M %A Rotter, Jerome I %A Toniolo, Daniela %A Uitterlinden, André G %A Ulivi, Sheila %A Völzke, Henry %A Wareham, Nicholas J %A Weir, David R %A Yerges-Armstrong, Laura M %A Price, Alkes L %A Stefansson, Kari %A Visser, Jenny A %A Ong, Ken K %A Chang-Claude, Jenny %A Murabito, Joanne M %A Perry, John R B %A Murray, Anna %X

Menopause timing has a substantial impact on infertility and risk of disease, including breast cancer, but the underlying mechanisms are poorly understood. We report a dual strategy in ∼70,000 women to identify common and low-frequency protein-coding variation associated with age at natural menopause (ANM). We identified 44 regions with common variants, including two regions harboring additional rare missense alleles of large effect. We found enrichment of signals in or near genes involved in delayed puberty, highlighting the first molecular links between the onset and end of reproductive lifespan. Pathway analyses identified major association with DNA damage response (DDR) genes, including the first common coding variant in BRCA1 associated with any complex trait. Mendelian randomization analyses supported a causal effect of later ANM on breast cancer risk (∼6% increase in risk per year; P = 3 × 10(-14)), likely mediated by prolonged sex hormone exposure rather than DDR mechanisms.

%B Nat Genet %V 47 %P 1294-303 %8 2015 Nov %G eng %N 11 %1 http://www.ncbi.nlm.nih.gov/pubmed/26414677?dopt=Abstract %R 10.1038/ng.3412 %0 Journal Article %J Nat Commun %D 2015 %T Rare coding variants and X-linked loci associated with age at menarche. %A Lunetta, Kathryn L %A Day, Felix R %A Sulem, Patrick %A Ruth, Katherine S %A Tung, Joyce Y %A Hinds, David A %A Esko, Tõnu %A Elks, Cathy E %A Altmaier, Elisabeth %A He, Chunyan %A Huffman, Jennifer E %A Mihailov, Evelin %A Porcu, Eleonora %A Robino, Antonietta %A Rose, Lynda M %A Schick, Ursula M %A Stolk, Lisette %A Teumer, Alexander %A Thompson, Deborah J %A Traglia, Michela %A Wang, Carol A %A Yerges-Armstrong, Laura M %A Antoniou, Antonis C %A Barbieri, Caterina %A Coviello, Andrea D %A Cucca, Francesco %A Demerath, Ellen W %A Dunning, Alison M %A Gandin, Ilaria %A Grove, Megan L %A Gudbjartsson, Daniel F %A Hocking, Lynne J %A Hofman, Albert %A Huang, Jinyan %A Jackson, Rebecca D %A Karasik, David %A Kriebel, Jennifer %A Lange, Ethan M %A Lange, Leslie A %A Langenberg, Claudia %A Li, Xin %A Luan, Jian'an %A Mägi, Reedik %A Morrison, Alanna C %A Padmanabhan, Sandosh %A Pirie, Ailith %A Polasek, Ozren %A Porteous, David %A Reiner, Alex P %A Rivadeneira, Fernando %A Rudan, Igor %A Sala, Cinzia F %A Schlessinger, David %A Scott, Robert A %A Stöckl, Doris %A Visser, Jenny A %A Völker, Uwe %A Vozzi, Diego %A Wilson, James G %A Zygmunt, Marek %A Boerwinkle, Eric %A Buring, Julie E %A Crisponi, Laura %A Easton, Douglas F %A Hayward, Caroline %A Hu, Frank B %A Liu, Simin %A Metspalu, Andres %A Pennell, Craig E %A Ridker, Paul M %A Strauch, Konstantin %A Streeten, Elizabeth A %A Toniolo, Daniela %A Uitterlinden, André G %A Ulivi, Sheila %A Völzke, Henry %A Wareham, Nicholas J %A Wellons, Melissa %A Franceschini, Nora %A Chasman, Daniel I %A Thorsteinsdottir, Unnur %A Murray, Anna %A Stefansson, Kari %A Murabito, Joanne M %A Ong, Ken K %A Perry, John R B %X

More than 100 loci have been identified for age at menarche by genome-wide association studies; however, collectively these explain only ∼3% of the trait variance. Here we test two overlooked sources of variation in 192,974 European ancestry women: low-frequency protein-coding variants and X-chromosome variants. Five missense/nonsense variants (in ALMS1/LAMB2/TNRC6A/TACR3/PRKAG1) are associated with age at menarche (minor allele frequencies 0.08-4.6%; effect sizes 0.08-1.25 years per allele; P<5 × 10(-8)). In addition, we identify common X-chromosome loci at IGSF1 (rs762080, P=9.4 × 10(-13)) and FAAH2 (rs5914101, P=4.9 × 10(-10)). Highlighted genes implicate cellular energy homeostasis, post-transcriptional gene silencing and fatty-acid amide signalling. A frequently reported mutation in TACR3 for idiopathic hypogonatrophic hypogonadism (p.W275X) is associated with 1.25-year-later menarche (P=2.8 × 10(-11)), illustrating the utility of population studies to estimate the penetrance of reportedly pathogenic mutations. Collectively, these novel variants explain ∼0.5% variance, indicating that these overlooked sources of variation do not substantially explain the 'missing heritability' of this complex trait.

%B Nat Commun %V 6 %P 7756 %8 2015 %G eng %1 http://www.ncbi.nlm.nih.gov/pubmed/26239645?dopt=Abstract %R 10.1038/ncomms8756 %0 Journal Article %J Nature %D 2014 %T Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. %A Perry, John R B %A Day, Felix %A Elks, Cathy E %A Sulem, Patrick %A Thompson, Deborah J %A Ferreira, Teresa %A He, Chunyan %A Chasman, Daniel I %A Esko, Tõnu %A Thorleifsson, Gudmar %A Albrecht, Eva %A Ang, Wei Q %A Corre, Tanguy %A Cousminer, Diana L %A Feenstra, Bjarke %A Franceschini, Nora %A Ganna, Andrea %A Johnson, Andrew D %A Kjellqvist, Sanela %A Lunetta, Kathryn L %A McMahon, George %A Nolte, Ilja M %A Paternoster, Lavinia %A Porcu, Eleonora %A Smith, Albert V %A Stolk, Lisette %A Teumer, Alexander %A Tšernikova, Natalia %A Tikkanen, Emmi %A Ulivi, Sheila %A Wagner, Erin K %A Amin, Najaf %A Bierut, Laura J %A Byrne, Enda M %A Hottenga, Jouke-Jan %A Koller, Daniel L %A Mangino, Massimo %A Pers, Tune H %A Yerges-Armstrong, Laura M %A Hua Zhao, Jing %A Andrulis, Irene L %A Anton-Culver, Hoda %A Atsma, Femke %A Bandinelli, Stefania %A Beckmann, Matthias W %A Benitez, Javier %A Blomqvist, Carl %A Bojesen, Stig E %A Bolla, Manjeet K %A Bonanni, Bernardo %A Brauch, Hiltrud %A Brenner, Hermann %A Buring, Julie E %A Chang-Claude, Jenny %A Chanock, Stephen %A Chen, Jinhui %A Chenevix-Trench, Georgia %A Collée, J Margriet %A Couch, Fergus J %A Couper, David %A Coviello, Andrea D %A Cox, Angela %A Czene, Kamila %A d'Adamo, Adamo Pio %A Davey Smith, George %A De Vivo, Immaculata %A Demerath, Ellen W %A Dennis, Joe %A Devilee, Peter %A Dieffenbach, Aida K %A Dunning, Alison M %A Eiriksdottir, Gudny %A Eriksson, Johan G %A Fasching, Peter A %A Ferrucci, Luigi %A Flesch-Janys, Dieter %A Flyger, Henrik %A Foroud, Tatiana %A Franke, Lude %A Garcia, Melissa E %A García-Closas, Montserrat %A Geller, Frank %A de Geus, Eco E J %A Giles, Graham G %A Gudbjartsson, Daniel F %A Gudnason, Vilmundur %A Guenel, Pascal %A Guo, Suiqun %A Hall, Per %A Hamann, Ute %A Haring, Robin %A Hartman, Catharina A %A Heath, Andrew C %A Hofman, Albert %A Hooning, Maartje J %A Hopper, John L %A Hu, Frank B %A Hunter, David J %A Karasik, David %A Kiel, Douglas P %A Knight, Julia A %A Kosma, Veli-Matti %A Kutalik, Zoltán %A Lai, Sandra %A Lambrechts, Diether %A Lindblom, Annika %A Mägi, Reedik %A Magnusson, Patrik K %A Mannermaa, Arto %A Martin, Nicholas G %A Masson, Gisli %A McArdle, Patrick F %A McArdle, Wendy L %A Melbye, Mads %A Michailidou, Kyriaki %A Mihailov, Evelin %A Milani, Lili %A Milne, Roger L %A Nevanlinna, Heli %A Neven, Patrick %A Nohr, Ellen A %A Oldehinkel, Albertine J %A Oostra, Ben A %A Palotie, Aarno %A Peacock, Munro %A Pedersen, Nancy L %A Peterlongo, Paolo %A Peto, Julian %A Pharoah, Paul D P %A Postma, Dirkje S %A Pouta, Anneli %A Pylkäs, Katri %A Radice, Paolo %A Ring, Susan %A Rivadeneira, Fernando %A Robino, Antonietta %A Rose, Lynda M %A Rudolph, Anja %A Salomaa, Veikko %A Sanna, Serena %A Schlessinger, David %A Schmidt, Marjanka K %A Southey, Mellissa C %A Sovio, Ulla %A Stampfer, Meir J %A Stöckl, Doris %A Storniolo, Anna M %A Timpson, Nicholas J %A Tyrer, Jonathan %A Visser, Jenny A %A Vollenweider, Peter %A Völzke, Henry %A Waeber, Gerard %A Waldenberger, Melanie %A Wallaschofski, Henri %A Wang, Qin %A Willemsen, Gonneke %A Winqvist, Robert %A Wolffenbuttel, Bruce H R %A Wright, Margaret J %A Boomsma, Dorret I %A Econs, Michael J %A Khaw, Kay-Tee %A Loos, Ruth J F %A McCarthy, Mark I %A Montgomery, Grant W %A Rice, John P %A Streeten, Elizabeth A %A Thorsteinsdottir, Unnur %A van Duijn, Cornelia M %A Alizadeh, Behrooz Z %A Bergmann, Sven %A Boerwinkle, Eric %A Boyd, Heather A %A Crisponi, Laura %A Gasparini, Paolo %A Gieger, Christian %A Harris, Tamara B %A Ingelsson, Erik %A Järvelin, Marjo-Riitta %A Kraft, Peter %A Lawlor, Debbie %A Metspalu, Andres %A Pennell, Craig E %A Ridker, Paul M %A Snieder, Harold %A Sørensen, Thorkild I A %A Spector, Tim D %A Strachan, David P %A Uitterlinden, André G %A Wareham, Nicholas J %A Widen, Elisabeth %A Zygmunt, Marek %A Murray, Anna %A Easton, Douglas F %A Stefansson, Kari %A Murabito, Joanne M %A Ong, Ken K %K Adolescent %K Age Factors %K Alleles %K Body Mass Index %K Breast Neoplasms %K Cardiovascular Diseases %K Child %K Diabetes Mellitus, Type 2 %K Europe %K Female %K Genetic Loci %K Genome-Wide Association Study %K Genomic Imprinting %K Humans %K Hypothalamo-Hypophyseal System %K Intercellular Signaling Peptides and Proteins %K Male %K Membrane Proteins %K Menarche %K Obesity %K Ovary %K Parents %K Polymorphism, Single Nucleotide %K Potassium Channels, Tandem Pore Domain %K Proteins %K Quantitative Trait Loci %K Receptors, GABA-B %K Receptors, Retinoic Acid %K Ribonucleoproteins %X

Age at menarche is a marker of timing of puberty in females. It varies widely between individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, cardiovascular disease, breast cancer and all-cause mortality. Studies of rare human disorders of puberty and animal models point to a complex hypothalamic-pituitary-hormonal regulation, but the mechanisms that determine pubertal timing and underlie its links to disease risk remain unclear. Here, using genome-wide and custom-genotyping arrays in up to 182,416 women of European descent from 57 studies, we found robust evidence (P < 5 × 10(-8)) for 123 signals at 106 genomic loci associated with age at menarche. Many loci were associated with other pubertal traits in both sexes, and there was substantial overlap with genes implicated in body mass index and various diseases, including rare disorders of puberty. Menarche signals were enriched in imprinted regions, with three loci (DLK1-WDR25, MKRN3-MAGEL2 and KCNK9) demonstrating parent-of-origin-specific associations concordant with known parental expression patterns. Pathway analyses implicated nuclear hormone receptors, particularly retinoic acid and γ-aminobutyric acid-B2 receptor signalling, among novel mechanisms that regulate pubertal timing in humans. Our findings suggest a genetic architecture involving at least hundreds of common variants in the coordinated timing of the pubertal transition.

%B Nature %V 514 %P 92-7 %8 2014 Oct 2 %G eng %N 7520 %1 http://www.ncbi.nlm.nih.gov/pubmed/25231870?dopt=Abstract %R 10.1038/nature13545 %0 Journal Article %J Nat Genet %D 2012 %T Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. %A Stolk, Lisette %A Perry, John R B %A Chasman, Daniel I %A He, Chunyan %A Mangino, Massimo %A Sulem, Patrick %A Barbalic, Maja %A Broer, Linda %A Byrne, Enda M %A Ernst, Florian %A Esko, Tõnu %A Franceschini, Nora %A Gudbjartsson, Daniel F %A Hottenga, Jouke-Jan %A Kraft, Peter %A McArdle, Patrick F %A Porcu, Eleonora %A Shin, So-Youn %A Smith, Albert V %A van Wingerden, Sophie %A Zhai, Guangju %A Zhuang, Wei V %A Albrecht, Eva %A Alizadeh, Behrooz Z %A Aspelund, Thor %A Bandinelli, Stefania %A Lauc, Lovorka Barac %A Beckmann, Jacques S %A Boban, Mladen %A Boerwinkle, Eric %A Broekmans, Frank J %A Burri, Andrea %A Campbell, Harry %A Chanock, Stephen J %A Chen, Constance %A Cornelis, Marilyn C %A Corre, Tanguy %A Coviello, Andrea D %A d'Adamo, Pio %A Davies, Gail %A de Faire, Ulf %A de Geus, Eco J C %A Deary, Ian J %A Dedoussis, George V Z %A Deloukas, Panagiotis %A Ebrahim, Shah %A Eiriksdottir, Gudny %A Emilsson, Valur %A Eriksson, Johan G %A Fauser, Bart C J M %A Ferreli, Liana %A Ferrucci, Luigi %A Fischer, Krista %A Folsom, Aaron R %A Garcia, Melissa E %A Gasparini, Paolo %A Gieger, Christian %A Glazer, Nicole %A Grobbee, Diederick E %A Hall, Per %A Haller, Toomas %A Hankinson, Susan E %A Hass, Merli %A Hayward, Caroline %A Heath, Andrew C %A Hofman, Albert %A Ingelsson, Erik %A Janssens, A Cecile J W %A Johnson, Andrew D %A Karasik, David %A Kardia, Sharon L R %A Keyzer, Jules %A Kiel, Douglas P %A Kolcic, Ivana %A Kutalik, Zoltán %A Lahti, Jari %A Lai, Sandra %A Laisk, Triin %A Laven, Joop S E %A Lawlor, Debbie A %A Liu, Jianjun %A Lopez, Lorna M %A Louwers, Yvonne V %A Magnusson, Patrik K E %A Marongiu, Mara %A Martin, Nicholas G %A Klaric, Irena Martinovic %A Masciullo, Corrado %A McKnight, Barbara %A Medland, Sarah E %A Melzer, David %A Mooser, Vincent %A Navarro, Pau %A Newman, Anne B %A Nyholt, Dale R %A Onland-Moret, N Charlotte %A Palotie, Aarno %A Paré, Guillaume %A Parker, Alex N %A Pedersen, Nancy L %A Peeters, Petra H M %A Pistis, Giorgio %A Plump, Andrew S %A Polasek, Ozren %A Pop, Victor J M %A Psaty, Bruce M %A Räikkönen, Katri %A Rehnberg, Emil %A Rotter, Jerome I %A Rudan, Igor %A Sala, Cinzia %A Salumets, Andres %A Scuteri, Angelo %A Singleton, Andrew %A Smith, Jennifer A %A Snieder, Harold %A Soranzo, Nicole %A Stacey, Simon N %A Starr, John M %A Stathopoulou, Maria G %A Stirrups, Kathleen %A Stolk, Ronald P %A Styrkarsdottir, Unnur %A Sun, Yan V %A Tenesa, Albert %A Thorand, Barbara %A Toniolo, Daniela %A Tryggvadottir, Laufey %A Tsui, Kim %A Ulivi, Sheila %A van Dam, Rob M %A van der Schouw, Yvonne T %A van Gils, Carla H %A van Nierop, Peter %A Vink, Jacqueline M %A Visscher, Peter M %A Voorhuis, Marlies %A Waeber, Gerard %A Wallaschofski, Henri %A Wichmann, H Erich %A Widen, Elisabeth %A Wijnands-van Gent, Colette J M %A Willemsen, Gonneke %A Wilson, James F %A Wolffenbuttel, Bruce H R %A Wright, Alan F %A Yerges-Armstrong, Laura M %A Zemunik, Tatijana %A Zgaga, Lina %A Zillikens, M Carola %A Zygmunt, Marek %A Arnold, Alice M %A Boomsma, Dorret I %A Buring, Julie E %A Crisponi, Laura %A Demerath, Ellen W %A Gudnason, Vilmundur %A Harris, Tamara B %A Hu, Frank B %A Hunter, David J %A Launer, Lenore J %A Metspalu, Andres %A Montgomery, Grant W %A Oostra, Ben A %A Ridker, Paul M %A Sanna, Serena %A Schlessinger, David %A Spector, Tim D %A Stefansson, Kari %A Streeten, Elizabeth A %A Thorsteinsdottir, Unnur %A Uda, Manuela %A Uitterlinden, André G %A van Duijn, Cornelia M %A Völzke, Henry %A Murray, Anna %A Murabito, Joanne M %A Visser, Jenny A %A Lunetta, Kathryn L %K Age Factors %K DNA Helicases %K DNA Primase %K DNA Repair %K DNA Repair Enzymes %K DNA-Directed DNA Polymerase %K European Continental Ancestry Group %K Exodeoxyribonucleases %K Female %K Genetic Loci %K Genome-Wide Association Study %K Humans %K Immunity %K Menopause %K Polymorphism, Single Nucleotide %K Proteins %X

To newly identify loci for age at natural menopause, we carried out a meta-analysis of 22 genome-wide association studies (GWAS) in 38,968 women of European descent, with replication in up to 14,435 women. In addition to four known loci, we identified 13 loci newly associated with age at natural menopause (at P < 5 × 10(-8)). Candidate genes located at these newly associated loci include genes implicated in DNA repair (EXO1, HELQ, UIMC1, FAM175A, FANCI, TLK1, POLG and PRIM1) and immune function (IL11, NLRP11 and PRRC2A (also known as BAT2)). Gene-set enrichment pathway analyses using the full GWAS data set identified exoDNase, NF-κB signaling and mitochondrial dysfunction as biological processes related to timing of menopause.

%B Nat Genet %V 44 %P 260-8 %8 2012 Mar %G eng %N 3 %1 http://www.ncbi.nlm.nih.gov/pubmed/22267201?dopt=Abstract %R 10.1038/ng.1051 %0 Journal Article %J Nat Genet %D 2010 %T Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. %A Elks, Cathy E %A Perry, John R B %A Sulem, Patrick %A Chasman, Daniel I %A Franceschini, Nora %A He, Chunyan %A Lunetta, Kathryn L %A Visser, Jenny A %A Byrne, Enda M %A Cousminer, Diana L %A Gudbjartsson, Daniel F %A Esko, Tõnu %A Feenstra, Bjarke %A Hottenga, Jouke-Jan %A Koller, Daniel L %A Kutalik, Zoltán %A Lin, Peng %A Mangino, Massimo %A Marongiu, Mara %A McArdle, Patrick F %A Smith, Albert V %A Stolk, Lisette %A van Wingerden, Sophie H %A Zhao, Jing Hua %A Albrecht, Eva %A Corre, Tanguy %A Ingelsson, Erik %A Hayward, Caroline %A Magnusson, Patrik K E %A Smith, Erin N %A Ulivi, Shelia %A Warrington, Nicole M %A Zgaga, Lina %A Alavere, Helen %A Amin, Najaf %A Aspelund, Thor %A Bandinelli, Stefania %A Barroso, Inês %A Berenson, Gerald S %A Bergmann, Sven %A Blackburn, Hannah %A Boerwinkle, Eric %A Buring, Julie E %A Busonero, Fabio %A Campbell, Harry %A Chanock, Stephen J %A Chen, Wei %A Cornelis, Marilyn C %A Couper, David %A Coviello, Andrea D %A d'Adamo, Pio %A de Faire, Ulf %A de Geus, Eco J C %A Deloukas, Panos %A Döring, Angela %A Smith, George Davey %A Easton, Douglas F %A Eiriksdottir, Gudny %A Emilsson, Valur %A Eriksson, Johan %A Ferrucci, Luigi %A Folsom, Aaron R %A Foroud, Tatiana %A Garcia, Melissa %A Gasparini, Paolo %A Geller, Frank %A Gieger, Christian %A Gudnason, Vilmundur %A Hall, Per %A Hankinson, Susan E %A Ferreli, Liana %A Heath, Andrew C %A Hernandez, Dena G %A Hofman, Albert %A Hu, Frank B %A Illig, Thomas %A Järvelin, Marjo-Riitta %A Johnson, Andrew D %A Karasik, David %A Khaw, Kay-Tee %A Kiel, Douglas P %A Kilpeläinen, Tuomas O %A Kolcic, Ivana %A Kraft, Peter %A Launer, Lenore J %A Laven, Joop S E %A Li, Shengxu %A Liu, Jianjun %A Levy, Daniel %A Martin, Nicholas G %A McArdle, Wendy L %A Melbye, Mads %A Mooser, Vincent %A Murray, Jeffrey C %A Murray, Sarah S %A Nalls, Michael A %A Navarro, Pau %A Nelis, Mari %A Ness, Andrew R %A Northstone, Kate %A Oostra, Ben A %A Peacock, Munro %A Palmer, Lyle J %A Palotie, Aarno %A Paré, Guillaume %A Parker, Alex N %A Pedersen, Nancy L %A Peltonen, Leena %A Pennell, Craig E %A Pharoah, Paul %A Polasek, Ozren %A Plump, Andrew S %A Pouta, Anneli %A Porcu, Eleonora %A Rafnar, Thorunn %A Rice, John P %A Ring, Susan M %A Rivadeneira, Fernando %A Rudan, Igor %A Sala, Cinzia %A Salomaa, Veikko %A Sanna, Serena %A Schlessinger, David %A Schork, Nicholas J %A Scuteri, Angelo %A Segrè, Ayellet V %A Shuldiner, Alan R %A Soranzo, Nicole %A Sovio, Ulla %A Srinivasan, Sathanur R %A Strachan, David P %A Tammesoo, Mar-Liis %A Tikkanen, Emmi %A Toniolo, Daniela %A Tsui, Kim %A Tryggvadottir, Laufey %A Tyrer, Jonathon %A Uda, Manuela %A van Dam, Rob M %A van Meurs, Joyce B J %A Vollenweider, Peter %A Waeber, Gerard %A Wareham, Nicholas J %A Waterworth, Dawn M %A Weedon, Michael N %A Wichmann, H Erich %A Willemsen, Gonneke %A Wilson, James F %A Wright, Alan F %A Young, Lauren %A Zhai, Guangju %A Zhuang, Wei Vivian %A Bierut, Laura J %A Boomsma, Dorret I %A Boyd, Heather A %A Crisponi, Laura %A Demerath, Ellen W %A van Duijn, Cornelia M %A Econs, Michael J %A Harris, Tamara B %A Hunter, David J %A Loos, Ruth J F %A Metspalu, Andres %A Montgomery, Grant W %A Ridker, Paul M %A Spector, Tim D %A Streeten, Elizabeth A %A Stefansson, Kari %A Thorsteinsdottir, Unnur %A Uitterlinden, André G %A Widen, Elisabeth %A Murabito, Joanne M %A Ong, Ken K %A Murray, Anna %K Adolescent %K Aging %K Body Height %K Body Size %K Child %K DNA Copy Number Variations %K Female %K Genetic Loci %K Genetic Predisposition to Disease %K Genome-Wide Association Study %K Humans %K Inheritance Patterns %K Menarche %K Obesity %K Polymorphism, Single Nucleotide %K Quantitative Trait Loci %K Reproducibility of Results %K Time Factors %X

To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide association studies in 87,802 women of European descent, with replication in up to 14,731 women. In addition to the known loci at LIN28B (P = 5.4 × 10⁻⁶⁰) and 9q31.2 (P = 2.2 × 10⁻³³), we identified 30 new menarche loci (all P < 5 × 10⁻⁸) and found suggestive evidence for a further 10 loci (P < 1.9 × 10⁻⁶). The new loci included four previously associated with body mass index (in or near FTO, SEC16B, TRA2B and TMEM18), three in or near other genes implicated in energy homeostasis (BSX, CRTC1 and MCHR2) and three in or near genes implicated in hormonal regulation (INHBA, PCSK2 and RXRG). Ingenuity and gene-set enrichment pathway analyses identified coenzyme A and fatty acid biosynthesis as biological processes related to menarche timing.

%B Nat Genet %V 42 %P 1077-85 %8 2010 Dec %G eng %N 12 %1 http://www.ncbi.nlm.nih.gov/pubmed/21102462?dopt=Abstract %R 10.1038/ng.714