<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Prins, Bram P</style></author><author><style face="normal" font="default" size="100%">Mead, Timothy J</style></author><author><style face="normal" font="default" size="100%">Brody, Jennifer A</style></author><author><style face="normal" font="default" size="100%">Sveinbjornsson, Gardar</style></author><author><style face="normal" font="default" size="100%">Ntalla, Ioanna</style></author><author><style face="normal" font="default" size="100%">Bihlmeyer, Nathan A</style></author><author><style face="normal" font="default" size="100%">van den Berg, Marten</style></author><author><style face="normal" font="default" size="100%">Bork-Jensen, Jette</style></author><author><style face="normal" font="default" size="100%">Cappellani, Stefania</style></author><author><style face="normal" font="default" size="100%">Van Duijvenboden, Stefan</style></author><author><style face="normal" font="default" size="100%">Klena, Nikolai T</style></author><author><style face="normal" font="default" size="100%">Gabriel, George C</style></author><author><style face="normal" font="default" size="100%">Liu, Xiaoqin</style></author><author><style face="normal" font="default" size="100%">Gulec, Cagri</style></author><author><style face="normal" font="default" size="100%">Grarup, Niels</style></author><author><style face="normal" font="default" size="100%">Haessler, Jeffrey</style></author><author><style face="normal" font="default" size="100%">Hall, Leanne M</style></author><author><style face="normal" font="default" size="100%">Iorio, Annamaria</style></author><author><style face="normal" font="default" size="100%">Isaacs, Aaron</style></author><author><style face="normal" font="default" size="100%">Li-Gao, Ruifang</style></author><author><style face="normal" font="default" size="100%">Lin, Honghuang</style></author><author><style face="normal" font="default" size="100%">Liu, Ching-Ti</style></author><author><style face="normal" font="default" size="100%">Lyytikäinen, Leo-Pekka</style></author><author><style face="normal" font="default" size="100%">Marten, Jonathan</style></author><author><style face="normal" font="default" size="100%">Mei, Hao</style></author><author><style face="normal" font="default" size="100%">Müller-Nurasyid, Martina</style></author><author><style face="normal" font="default" size="100%">Orini, Michele</style></author><author><style face="normal" font="default" size="100%">Padmanabhan, Sandosh</style></author><author><style face="normal" font="default" size="100%">Radmanesh, Farid</style></author><author><style face="normal" font="default" size="100%">Ramirez, Julia</style></author><author><style face="normal" font="default" size="100%">Robino, Antonietta</style></author><author><style face="normal" font="default" size="100%">Schwartz, Molly</style></author><author><style face="normal" font="default" size="100%">van Setten, Jessica</style></author><author><style face="normal" font="default" size="100%">Smith, Albert V</style></author><author><style face="normal" font="default" size="100%">Verweij, Niek</style></author><author><style face="normal" font="default" size="100%">Warren, Helen R</style></author><author><style face="normal" font="default" size="100%">Weiss, Stefan</style></author><author><style face="normal" font="default" size="100%">Alonso, Alvaro</style></author><author><style face="normal" font="default" size="100%">Arnar, David O</style></author><author><style face="normal" font="default" size="100%">Bots, Michiel L</style></author><author><style face="normal" font="default" size="100%">de Boer, Rudolf A</style></author><author><style face="normal" font="default" size="100%">Dominiczak, Anna F</style></author><author><style face="normal" font="default" size="100%">Eijgelsheim, Mark</style></author><author><style face="normal" font="default" size="100%">Ellinor, Patrick T</style></author><author><style face="normal" font="default" size="100%">Guo, Xiuqing</style></author><author><style face="normal" font="default" size="100%">Felix, Stephan B</style></author><author><style face="normal" font="default" size="100%">Harris, Tamara B</style></author><author><style face="normal" font="default" size="100%">Hayward, Caroline</style></author><author><style face="normal" font="default" size="100%">Heckbert, Susan R</style></author><author><style face="normal" font="default" size="100%">Huang, Paul L</style></author><author><style face="normal" font="default" size="100%">Jukema, J W</style></author><author><style face="normal" font="default" size="100%">Kähönen, Mika</style></author><author><style face="normal" font="default" size="100%">Kors, Jan A</style></author><author><style face="normal" font="default" size="100%">Lambiase, Pier D</style></author><author><style face="normal" font="default" size="100%">Launer, Lenore J</style></author><author><style face="normal" font="default" size="100%">Li, Man</style></author><author><style face="normal" font="default" size="100%">Linneberg, Allan</style></author><author><style face="normal" font="default" size="100%">Nelson, Christopher P</style></author><author><style face="normal" font="default" size="100%">Pedersen, Oluf</style></author><author><style face="normal" font="default" size="100%">Perez, Marco</style></author><author><style face="normal" font="default" size="100%">Peters, Annette</style></author><author><style face="normal" font="default" size="100%">Polasek, Ozren</style></author><author><style face="normal" font="default" size="100%">Psaty, Bruce M</style></author><author><style face="normal" font="default" size="100%">Raitakari, Olli T</style></author><author><style face="normal" font="default" size="100%">Rice, Kenneth M</style></author><author><style face="normal" font="default" size="100%">Rotter, Jerome I</style></author><author><style face="normal" font="default" size="100%">Sinner, Moritz F</style></author><author><style face="normal" font="default" size="100%">Soliman, Elsayed Z</style></author><author><style face="normal" font="default" size="100%">Spector, Tim D</style></author><author><style face="normal" font="default" size="100%">Strauch, Konstantin</style></author><author><style face="normal" font="default" size="100%">Thorsteinsdottir, Unnur</style></author><author><style face="normal" font="default" size="100%">Tinker, Andrew</style></author><author><style face="normal" font="default" size="100%">Trompet, Stella</style></author><author><style face="normal" font="default" size="100%">Uitterlinden, André</style></author><author><style face="normal" font="default" size="100%">Vaartjes, Ilonca</style></author><author><style face="normal" font="default" size="100%">van der Meer, Peter</style></author><author><style face="normal" font="default" size="100%">Völker, Uwe</style></author><author><style face="normal" font="default" size="100%">Völzke, Henry</style></author><author><style face="normal" font="default" size="100%">Waldenberger, Melanie</style></author><author><style face="normal" font="default" size="100%">Wilson, James G</style></author><author><style face="normal" font="default" size="100%">Xie, Zhijun</style></author><author><style face="normal" font="default" size="100%">Asselbergs, Folkert W</style></author><author><style face="normal" font="default" size="100%">Dörr, Marcus</style></author><author><style face="normal" font="default" size="100%">van Duijn, Cornelia M</style></author><author><style face="normal" font="default" size="100%">Gasparini, Paolo</style></author><author><style face="normal" font="default" size="100%">Gudbjartsson, Daniel F</style></author><author><style face="normal" font="default" size="100%">Gudnason, Vilmundur</style></author><author><style face="normal" font="default" size="100%">Hansen, Torben</style></author><author><style face="normal" font="default" size="100%">Kääb, Stefan</style></author><author><style face="normal" font="default" size="100%">Kanters, Jørgen K</style></author><author><style face="normal" font="default" size="100%">Kooperberg, Charles</style></author><author><style face="normal" font="default" size="100%">Lehtimäki, Terho</style></author><author><style face="normal" font="default" size="100%">Lin, Henry J</style></author><author><style face="normal" font="default" size="100%">Lubitz, Steven A</style></author><author><style face="normal" font="default" size="100%">Mook-Kanamori, Dennis O</style></author><author><style face="normal" font="default" size="100%">Conti, Francesco J</style></author><author><style face="normal" font="default" size="100%">Newton-Cheh, Christopher H</style></author><author><style face="normal" font="default" size="100%">Rosand, Jonathan</style></author><author><style face="normal" font="default" size="100%">Rudan, Igor</style></author><author><style face="normal" font="default" size="100%">Samani, Nilesh J</style></author><author><style face="normal" font="default" size="100%">Sinagra, Gianfranco</style></author><author><style face="normal" font="default" size="100%">Smith, Blair H</style></author><author><style face="normal" font="default" size="100%">Holm, Hilma</style></author><author><style face="normal" font="default" size="100%">Stricker, Bruno H</style></author><author><style face="normal" font="default" size="100%">Ulivi, Sheila</style></author><author><style face="normal" font="default" size="100%">Sotoodehnia, Nona</style></author><author><style face="normal" font="default" size="100%">Apte, Suneel S</style></author><author><style face="normal" font="default" size="100%">van der Harst, Pim</style></author><author><style face="normal" font="default" size="100%">Stefansson, Kari</style></author><author><style face="normal" font="default" size="100%">Munroe, Patricia B</style></author><author><style face="normal" font="default" size="100%">Arking, Dan E</style></author><author><style face="normal" font="default" size="100%">Lo, Cecilia W</style></author><author><style face="normal" font="default" size="100%">Jamshidi, Yalda</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6.</style></title><secondary-title><style face="normal" font="default" size="100%">Genome Biol</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Genome Biol.</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">ADAMTS Proteins</style></keyword><keyword><style  face="normal" font="default" size="100%">African Continental Ancestry Group</style></keyword><keyword><style  face="normal" font="default" size="100%">Animals</style></keyword><keyword><style  face="normal" font="default" size="100%">Connexin 43</style></keyword><keyword><style  face="normal" font="default" size="100%">Electrocardiography</style></keyword><keyword><style  face="normal" font="default" size="100%">European Continental Ancestry Group</style></keyword><keyword><style  face="normal" font="default" size="100%">Exome</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">Gene Expression</style></keyword><keyword><style  face="normal" font="default" size="100%">Gene Expression Profiling</style></keyword><keyword><style  face="normal" font="default" size="100%">Genetic Loci</style></keyword><keyword><style  face="normal" font="default" size="100%">Genome-Wide Association Study</style></keyword><keyword><style  face="normal" font="default" size="100%">Heart Conduction System</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Male</style></keyword><keyword><style  face="normal" font="default" size="100%">Mice</style></keyword><keyword><style  face="normal" font="default" size="100%">Middle Aged</style></keyword><keyword><style  face="normal" font="default" size="100%">Myocardium</style></keyword><keyword><style  face="normal" font="default" size="100%">Open Reading Frames</style></keyword><keyword><style  face="normal" font="default" size="100%">Polymorphism, Single Nucleotide</style></keyword><keyword><style  face="normal" font="default" size="100%">Whole Exome Sequencing</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2018 07 17</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">19</style></volume><pages><style face="normal" font="default" size="100%">87</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;b&gt;BACKGROUND: &lt;/b&gt;Genome-wide association studies conducted on QRS duration, an electrocardiographic measurement associated with heart failure and sudden cardiac death, have led to novel biological insights into cardiac function. However, the variants identified fall predominantly in non-coding regions and their underlying mechanisms remain unclear.&lt;/p&gt;&lt;p&gt;&lt;b&gt;RESULTS: &lt;/b&gt;Here, we identify putative functional coding variation associated with changes in the QRS interval duration by combining Illumina HumanExome BeadChip genotype data from 77,898 participants of European ancestry and 7695 of African descent in our discovery cohort, followed by replication in 111,874 individuals of European ancestry from the UK Biobank and deCODE cohorts. We identify ten novel loci, seven within coding regions, including ADAMTS6, significantly associated with QRS duration in gene-based analyses. ADAMTS6 encodes a secreted metalloprotease of currently unknown function. In vitro validation analysis shows that the QRS-associated variants lead to impaired ADAMTS6 secretion and loss-of function analysis in mice demonstrates a previously unappreciated role for ADAMTS6 in connexin 43 gap junction expression, which is essential for myocardial conduction.&lt;/p&gt;&lt;p&gt;&lt;b&gt;CONCLUSIONS: &lt;/b&gt;Our approach identifies novel coding and non-coding variants underlying ventricular depolarization and provides a possible mechanism for the ADAMTS6-associated conduction changes.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><custom1><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/30012220?dopt=Abstract</style></custom1></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Tedja, Milly S</style></author><author><style face="normal" font="default" size="100%">Wojciechowski, Robert</style></author><author><style face="normal" font="default" size="100%">Hysi, Pirro G</style></author><author><style face="normal" font="default" size="100%">Eriksson, Nicholas</style></author><author><style face="normal" font="default" size="100%">Furlotte, Nicholas A</style></author><author><style face="normal" font="default" size="100%">Verhoeven, Virginie J M</style></author><author><style face="normal" font="default" size="100%">Iglesias, Adriana I</style></author><author><style face="normal" font="default" size="100%">Meester-Smoor, Magda A</style></author><author><style face="normal" font="default" size="100%">Tompson, Stuart W</style></author><author><style face="normal" font="default" size="100%">Fan, Qiao</style></author><author><style face="normal" font="default" size="100%">Khawaja, Anthony P</style></author><author><style face="normal" font="default" size="100%">Cheng, Ching-Yu</style></author><author><style face="normal" font="default" size="100%">Höhn, René</style></author><author><style face="normal" font="default" size="100%">Yamashiro, Kenji</style></author><author><style face="normal" font="default" size="100%">Wenocur, Adam</style></author><author><style face="normal" font="default" size="100%">Grazal, Clare</style></author><author><style face="normal" font="default" size="100%">Haller, Toomas</style></author><author><style face="normal" font="default" size="100%">Metspalu, Andres</style></author><author><style face="normal" font="default" size="100%">Wedenoja, Juho</style></author><author><style face="normal" font="default" size="100%">Jonas, Jost B</style></author><author><style face="normal" font="default" size="100%">Wang, Ya Xing</style></author><author><style face="normal" font="default" size="100%">Xie, Jing</style></author><author><style face="normal" font="default" size="100%">Mitchell, Paul</style></author><author><style face="normal" font="default" size="100%">Foster, Paul J</style></author><author><style face="normal" font="default" size="100%">Klein, Barbara E K</style></author><author><style face="normal" font="default" size="100%">Klein, Ronald</style></author><author><style face="normal" font="default" size="100%">Paterson, Andrew D</style></author><author><style face="normal" font="default" size="100%">Hosseini, S Mohsen</style></author><author><style face="normal" font="default" size="100%">Shah, Rupal L</style></author><author><style face="normal" font="default" size="100%">Williams, Cathy</style></author><author><style face="normal" font="default" size="100%">Teo, Yik Ying</style></author><author><style face="normal" font="default" size="100%">Tham, Yih Chung</style></author><author><style face="normal" font="default" size="100%">Gupta, Preeti</style></author><author><style face="normal" font="default" size="100%">Zhao, Wanting</style></author><author><style face="normal" font="default" size="100%">Shi, Yuan</style></author><author><style face="normal" font="default" size="100%">Saw, Woei-Yuh</style></author><author><style face="normal" font="default" size="100%">Tai, E-Shyong</style></author><author><style face="normal" font="default" size="100%">Sim, Xue Ling</style></author><author><style face="normal" font="default" size="100%">Huffman, Jennifer E</style></author><author><style face="normal" font="default" size="100%">Polasek, Ozren</style></author><author><style face="normal" font="default" size="100%">Hayward, Caroline</style></author><author><style face="normal" font="default" size="100%">Bencic, Goran</style></author><author><style face="normal" font="default" size="100%">Rudan, Igor</style></author><author><style face="normal" font="default" size="100%">Wilson, James F</style></author><author><style face="normal" font="default" size="100%">Joshi, Peter K</style></author><author><style face="normal" font="default" size="100%">Tsujikawa, Akitaka</style></author><author><style face="normal" font="default" size="100%">Matsuda, Fumihiko</style></author><author><style face="normal" font="default" size="100%">Whisenhunt, Kristina N</style></author><author><style face="normal" font="default" size="100%">Zeller, Tanja</style></author><author><style face="normal" font="default" size="100%">van der Spek, Peter J</style></author><author><style face="normal" font="default" size="100%">Haak, Roxanna</style></author><author><style face="normal" font="default" size="100%">Meijers-Heijboer, Hanne</style></author><author><style face="normal" font="default" size="100%">van Leeuwen, Elisabeth M</style></author><author><style face="normal" font="default" size="100%">Iyengar, Sudha K</style></author><author><style face="normal" font="default" size="100%">Lass, Jonathan H</style></author><author><style face="normal" font="default" size="100%">Hofman, Albert</style></author><author><style face="normal" font="default" size="100%">Rivadeneira, Fernando</style></author><author><style face="normal" font="default" size="100%">Uitterlinden, André G</style></author><author><style face="normal" font="default" size="100%">Vingerling, Johannes R</style></author><author><style face="normal" font="default" size="100%">Lehtimäki, Terho</style></author><author><style face="normal" font="default" size="100%">Raitakari, Olli T</style></author><author><style face="normal" font="default" size="100%">Biino, Ginevra</style></author><author><style face="normal" font="default" size="100%">Concas, Maria Pina</style></author><author><style face="normal" font="default" size="100%">Schwantes-An, Tae-Hwi</style></author><author><style face="normal" font="default" size="100%">Igo, Robert P</style></author><author><style face="normal" font="default" size="100%">Cuellar-Partida, Gabriel</style></author><author><style face="normal" font="default" size="100%">Martin, Nicholas G</style></author><author><style face="normal" font="default" size="100%">Craig, Jamie E</style></author><author><style face="normal" font="default" size="100%">Gharahkhani, Puya</style></author><author><style face="normal" font="default" size="100%">Williams, Katie M</style></author><author><style face="normal" font="default" size="100%">Nag, Abhishek</style></author><author><style face="normal" font="default" size="100%">Rahi, Jugnoo S</style></author><author><style face="normal" font="default" size="100%">Cumberland, Phillippa M</style></author><author><style face="normal" font="default" size="100%">Delcourt, Cécile</style></author><author><style face="normal" font="default" size="100%">Bellenguez, Céline</style></author><author><style face="normal" font="default" size="100%">Ried, Janina S</style></author><author><style face="normal" font="default" size="100%">Bergen, Arthur A</style></author><author><style face="normal" font="default" size="100%">Meitinger, Thomas</style></author><author><style face="normal" font="default" size="100%">Gieger, Christian</style></author><author><style face="normal" font="default" size="100%">Wong, Tien Yin</style></author><author><style face="normal" font="default" size="100%">Hewitt, Alex W</style></author><author><style face="normal" font="default" size="100%">Mackey, David A</style></author><author><style face="normal" font="default" size="100%">Simpson, Claire L</style></author><author><style face="normal" font="default" size="100%">Pfeiffer, Norbert</style></author><author><style face="normal" font="default" size="100%">Pärssinen, Olavi</style></author><author><style face="normal" font="default" size="100%">Baird, Paul N</style></author><author><style face="normal" font="default" size="100%">Vitart, Veronique</style></author><author><style face="normal" font="default" size="100%">Amin, Najaf</style></author><author><style face="normal" font="default" size="100%">van Duijn, Cornelia M</style></author><author><style face="normal" font="default" size="100%">Bailey-Wilson, Joan E</style></author><author><style face="normal" font="default" size="100%">Young, Terri L</style></author><author><style face="normal" font="default" size="100%">Saw, Seang-Mei</style></author><author><style face="normal" font="default" size="100%">Stambolian, Dwight</style></author><author><style face="normal" font="default" size="100%">MacGregor, Stuart</style></author><author><style face="normal" font="default" size="100%">Guggenheim, Jeremy A</style></author><author><style face="normal" font="default" size="100%">Tung, Joyce Y</style></author><author><style face="normal" font="default" size="100%">Hammond, Christopher J</style></author><author><style face="normal" font="default" size="100%">Klaver, Caroline C W</style></author></authors><translated-authors><author><style face="normal" font="default" size="100%">CREAM Consortium</style></author><author><style face="normal" font="default" size="100%">23andMe Research Team</style></author><author><style face="normal" font="default" size="100%">UK Biobank Eye and Vision Consortium</style></author></translated-authors></contributors><titles><title><style face="normal" font="default" size="100%">Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error.</style></title><secondary-title><style face="normal" font="default" size="100%">Nat Genet</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Nat. Genet.</style></alt-title></titles><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2018 Jun</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">50</style></volume><pages><style face="normal" font="default" size="100%">834-848</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Refractive errors, including myopia, are the most frequent eye disorders worldwide and an increasingly common cause of blindness. This genome-wide association meta-analysis in 160,420 participants and replication in 95,505 participants increased the number of established independent signals from 37 to 161 and showed high genetic correlation between Europeans and Asians (&gt;0.78). Expression experiments and comprehensive in silico analyses identified retinal cell physiology and light processing as prominent mechanisms, and also identified functional contributions to refractive-error development in all cell types of the neurosensory retina, retinal pigment epithelium, vascular endothelium and extracellular matrix. Newly identified genes implicate novel mechanisms such as rod-and-cone bipolar synaptic neurotransmission, anterior-segment morphology and angiogenesis. Thirty-one loci resided in or near regions transcribing small RNAs, thus suggesting a role for post-transcriptional regulation. Our results support the notion that refractive errors are caused by a light-dependent retina-to-sclera signaling cascade and delineate potential pathobiological molecular drivers.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><custom1><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/29808027?dopt=Abstract</style></custom1></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Shah, Rupal L</style></author><author><style face="normal" font="default" size="100%">Li, Qing</style></author><author><style face="normal" font="default" size="100%">Zhao, Wanting</style></author><author><style face="normal" font="default" size="100%">Tedja, Milly S</style></author><author><style face="normal" font="default" size="100%">Tideman, J Willem L</style></author><author><style face="normal" font="default" size="100%">Khawaja, Anthony P</style></author><author><style face="normal" font="default" size="100%">Fan, Qiao</style></author><author><style face="normal" font="default" size="100%">Yazar, Seyhan</style></author><author><style face="normal" font="default" size="100%">Williams, Katie M</style></author><author><style face="normal" font="default" size="100%">Verhoeven, Virginie J M</style></author><author><style face="normal" font="default" size="100%">Xie, Jing</style></author><author><style face="normal" font="default" size="100%">Wang, Ya Xing</style></author><author><style face="normal" font="default" size="100%">Hess, Moritz</style></author><author><style face="normal" font="default" size="100%">Nickels, Stefan</style></author><author><style face="normal" font="default" size="100%">Lackner, Karl J</style></author><author><style face="normal" font="default" size="100%">Pärssinen, Olavi</style></author><author><style face="normal" font="default" size="100%">Wedenoja, Juho</style></author><author><style face="normal" font="default" size="100%">Biino, Ginevra</style></author><author><style face="normal" font="default" size="100%">Concas, Maria Pina</style></author><author><style face="normal" font="default" size="100%">Uitterlinden, André</style></author><author><style face="normal" font="default" size="100%">Rivadeneira, Fernando</style></author><author><style face="normal" font="default" size="100%">Jaddoe, Vincent W V</style></author><author><style face="normal" font="default" size="100%">Hysi, Pirro G</style></author><author><style face="normal" font="default" size="100%">Sim, Xueling</style></author><author><style face="normal" font="default" size="100%">Tan, Nicholas</style></author><author><style face="normal" font="default" size="100%">Tham, Yih-Chung</style></author><author><style face="normal" font="default" size="100%">Sensaki, Sonoko</style></author><author><style face="normal" font="default" size="100%">Hofman, Albert</style></author><author><style face="normal" font="default" size="100%">Vingerling, Johannes R</style></author><author><style face="normal" font="default" size="100%">Jonas, Jost B</style></author><author><style face="normal" font="default" size="100%">Mitchell, Paul</style></author><author><style face="normal" font="default" size="100%">Hammond, Christopher J</style></author><author><style face="normal" font="default" size="100%">Höhn, René</style></author><author><style face="normal" font="default" size="100%">Baird, Paul N</style></author><author><style face="normal" font="default" size="100%">Wong, Tien-Yin</style></author><author><style face="normal" font="default" size="100%">Cheng, Chinfsg-Yu</style></author><author><style face="normal" font="default" size="100%">Teo, Yik Ying</style></author><author><style face="normal" font="default" size="100%">Mackey, David A</style></author><author><style face="normal" font="default" size="100%">Williams, Cathy</style></author><author><style face="normal" font="default" size="100%">Saw, Seang-Mei</style></author><author><style face="normal" font="default" size="100%">Klaver, Caroline C W</style></author><author><style face="normal" font="default" size="100%">Guggenheim, Jeremy A</style></author><author><style face="normal" font="default" size="100%">Bailey-Wilson, Joan E</style></author></authors><translated-authors><author><style face="normal" font="default" size="100%">CREAM Consortium</style></author></translated-authors></contributors><titles><title><style face="normal" font="default" size="100%">A genome-wide association study of corneal astigmatism: The CREAM Consortium.</style></title><secondary-title><style face="normal" font="default" size="100%">Mol Vis</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Mol. Vis.</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acid Phosphatase</style></keyword><keyword><style  face="normal" font="default" size="100%">Asian Continental Ancestry Group</style></keyword><keyword><style  face="normal" font="default" size="100%">Astigmatism</style></keyword><keyword><style  face="normal" font="default" size="100%">Claudins</style></keyword><keyword><style  face="normal" font="default" size="100%">Cohort Studies</style></keyword><keyword><style  face="normal" font="default" size="100%">Cornea</style></keyword><keyword><style  face="normal" font="default" size="100%">Corneal Diseases</style></keyword><keyword><style  face="normal" font="default" size="100%">European Continental Ancestry Group</style></keyword><keyword><style  face="normal" font="default" size="100%">Gene Expression</style></keyword><keyword><style  face="normal" font="default" size="100%">Genetic Predisposition to Disease</style></keyword><keyword><style  face="normal" font="default" size="100%">Genome-Wide Association Study</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Intracellular Signaling Peptides and Proteins</style></keyword><keyword><style  face="normal" font="default" size="100%">Odds Ratio</style></keyword><keyword><style  face="normal" font="default" size="100%">Polymorphism, Single Nucleotide</style></keyword><keyword><style  face="normal" font="default" size="100%">Receptor, Platelet-Derived Growth Factor alpha</style></keyword><keyword><style  face="normal" font="default" size="100%">Software</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">24</style></volume><pages><style face="normal" font="default" size="100%">127-142</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;b&gt;Purpose: &lt;/b&gt;To identify genes and genetic markers associated with corneal astigmatism.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Methods: &lt;/b&gt;A meta-analysis of genome-wide association studies (GWASs) of corneal astigmatism undertaken for 14 European ancestry (n=22,250) and 8 Asian ancestry (n=9,120) cohorts was performed by the Consortium for Refractive Error and Myopia. Cases were defined as having &gt;0.75 diopters of corneal astigmatism. Subsequent gene-based and gene-set analyses of the meta-analyzed results of European ancestry cohorts were performed using VEGAS2 and MAGMA software. Additionally, estimates of single nucleotide polymorphism (SNP)-based heritability for corneal and refractive astigmatism and the spherical equivalent were calculated for Europeans using LD score regression.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results: &lt;/b&gt;The meta-analysis of all cohorts identified a genome-wide significant locus near the platelet-derived growth factor receptor alpha () gene: top SNP: rs7673984, odds ratio=1.12 (95% CI:1.08-1.16), p=5.55×10. No other genome-wide significant loci were identified in the combined analysis or European/Asian ancestry-specific analyses. Gene-based analysis identified three novel candidate genes for corneal astigmatism in Europeans-claudin-7 (), acid phosphatase 2, lysosomal (), and TNF alpha-induced protein 8 like 3 ().&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions: &lt;/b&gt;In addition to replicating a previously identified genome-wide significant locus for corneal astigmatism near the  gene, gene-based analysis identified three novel candidate genes, , , and , that warrant further investigation to understand their role in the pathogenesis of corneal astigmatism. The much lower number of genetic variants and genes demonstrating an association with corneal astigmatism compared to published spherical equivalent GWAS analyses suggest a greater influence of rare genetic variants, non-additive genetic effects, or environmental factors in the development of astigmatism.&lt;/p&gt;</style></abstract><custom1><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/29422769?dopt=Abstract</style></custom1></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Toson, Bruno</style></author><author><style face="normal" font="default" size="100%">Dos Santos, Eduardo José</style></author><author><style face="normal" font="default" size="100%">Adelino, José Eduardo</style></author><author><style face="normal" font="default" size="100%">Sandrin-Garcia, Paula</style></author><author><style face="normal" font="default" size="100%">Crovella, Sergio</style></author><author><style face="normal" font="default" size="100%">Louzada-Júnior, Paulo</style></author><author><style face="normal" font="default" size="100%">Oliveira, Renê Donizete Ribeiro</style></author><author><style face="normal" font="default" size="100%">Pedroza, Larysse Santa Rosa Aquino</style></author><author><style face="normal" font="default" size="100%">de Fátima Lobato Cunha Sauma, Maria</style></author><author><style face="normal" font="default" size="100%">de Lima, Clayton Pereira Silva</style></author><author><style face="normal" font="default" size="100%">Barbosa, Fabiola Brasil</style></author><author><style face="normal" font="default" size="100%">Brenol, Claiton Viegas</style></author><author><style face="normal" font="default" size="100%">Xavier, Ricardo Machado</style></author><author><style face="normal" font="default" size="100%">Chies, José Artur Bogo</style></author><author><style face="normal" font="default" size="100%">Veit, Tiago Degani</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">CCR5Δ32 and the genetic susceptibility to rheumatoid arthritis in admixed populations: a multicentre study.</style></title><secondary-title><style face="normal" font="default" size="100%">Rheumatology (Oxford)</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Rheumatology (Oxford)</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Arthritis, Rheumatoid</style></keyword><keyword><style  face="normal" font="default" size="100%">Brazil</style></keyword><keyword><style  face="normal" font="default" size="100%">Case-Control Studies</style></keyword><keyword><style  face="normal" font="default" size="100%">Consanguinity</style></keyword><keyword><style  face="normal" font="default" size="100%">Gene Frequency</style></keyword><keyword><style  face="normal" font="default" size="100%">Genetic Predisposition to Disease</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Polymorphism, Single Nucleotide</style></keyword><keyword><style  face="normal" font="default" size="100%">Receptors, CCR5</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2017 03 01</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">56</style></volume><pages><style face="normal" font="default" size="100%">495-497</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><issue><style face="normal" font="default" size="100%">3</style></issue><custom1><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/28082621?dopt=Abstract</style></custom1></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Xue, Yali</style></author><author><style face="normal" font="default" size="100%">Mezzavilla, Massimo</style></author><author><style face="normal" font="default" size="100%">Haber, Marc</style></author><author><style face="normal" font="default" size="100%">McCarthy, Shane</style></author><author><style face="normal" font="default" size="100%">Chen, Yuan</style></author><author><style face="normal" font="default" size="100%">Narasimhan, Vagheesh</style></author><author><style face="normal" font="default" size="100%">Gilly, Arthur</style></author><author><style face="normal" font="default" size="100%">Ayub, Qasim</style></author><author><style face="normal" font="default" size="100%">Colonna, Vincenza</style></author><author><style face="normal" font="default" size="100%">Southam, Lorraine</style></author><author><style face="normal" font="default" size="100%">Finan, Christopher</style></author><author><style face="normal" font="default" size="100%">Massaia, Andrea</style></author><author><style face="normal" font="default" size="100%">Chheda, Himanshu</style></author><author><style face="normal" font="default" size="100%">Palta, Priit</style></author><author><style face="normal" font="default" size="100%">Ritchie, Graham</style></author><author><style face="normal" font="default" size="100%">Asimit, Jennifer</style></author><author><style face="normal" font="default" size="100%">Dedoussis, George</style></author><author><style face="normal" font="default" size="100%">Gasparini, Paolo</style></author><author><style face="normal" font="default" size="100%">Palotie, Aarno</style></author><author><style face="normal" font="default" size="100%">Ripatti, Samuli</style></author><author><style face="normal" font="default" size="100%">Soranzo, Nicole</style></author><author><style face="normal" font="default" size="100%">Toniolo, Daniela</style></author><author><style face="normal" font="default" size="100%">Wilson, James F</style></author><author><style face="normal" font="default" size="100%">Durbin, Richard</style></author><author><style face="normal" font="default" size="100%">Tyler-Smith, Chris</style></author><author><style face="normal" font="default" size="100%">Zeggini, Eleftheria</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Enrichment of low-frequency functional variants revealed by whole-genome sequencing of multiple isolated European populations.</style></title><secondary-title><style face="normal" font="default" size="100%">Nat Commun</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Nat Commun</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">European Continental Ancestry Group</style></keyword><keyword><style  face="normal" font="default" size="100%">Gene Frequency</style></keyword><keyword><style  face="normal" font="default" size="100%">Genetic Variation</style></keyword><keyword><style  face="normal" font="default" size="100%">Genetics, Population</style></keyword><keyword><style  face="normal" font="default" size="100%">Genome, Human</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Polymorphism, Single Nucleotide</style></keyword><keyword><style  face="normal" font="default" size="100%">Whole Genome Sequencing</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2017 06 23</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">15927</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;The genetic features of isolated populations can boost power in complex-trait association studies, and an in-depth understanding of how their genetic variation has been shaped by their demographic history can help leverage these advantageous characteristics. Here, we perform a comprehensive investigation using 3,059 newly generated low-depth whole-genome sequences from eight European isolates and two matched general populations, together with published data from the 1000 Genomes Project and UK10K. Sequencing data give deeper and richer insights into population demography and genetic characteristics than genotype-chip data, distinguishing related populations more effectively and allowing their functional variants to be studied more fully. We demonstrate relaxation of purifying selection in the isolates, leading to enrichment of rare and low-frequency functional variants, using novel statistics, DVxy and SVxy. We also develop an isolation-index (Isx) that predicts the overall level of such key genetic characteristics and can thus help guide population choice in future complex-trait association studies.&lt;/p&gt;</style></abstract><custom1><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/28643794?dopt=Abstract</style></custom1></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Cegolon, L</style></author><author><style face="normal" font="default" size="100%">Heymann, W C</style></author><author><style face="normal" font="default" size="100%">Xodo, C</style></author><author><style face="normal" font="default" size="100%">Lange, J H</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Training in Occupational Medicine: Jurisprudential Malfunctions in the Italian System and European Perspectives.</style></title><secondary-title><style face="normal" font="default" size="100%">Ann Ig</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Ann Ig</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Certification</style></keyword><keyword><style  face="normal" font="default" size="100%">European Union</style></keyword><keyword><style  face="normal" font="default" size="100%">Italy</style></keyword><keyword><style  face="normal" font="default" size="100%">Occupational Medicine</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2017 May-Jun</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">29</style></volume><pages><style face="normal" font="default" size="100%">197-205</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;b&gt;BACKGROUND: &lt;/b&gt;To practice occupational health in Europe, a medical doctor must qualify in occupational medicine. This requires a period of postgraduate specialist medical training lasting a minimum of four years, in conformity with European regulations, to obtain a certificate of completion of training which is then mutually recognized within the entire European Union.&lt;/p&gt;&lt;p&gt;&lt;b&gt;DISCUSSION: &lt;/b&gt;In 2002 an Italian law allowed doctors specialized in public health medicine and legal/forensic medicine to also practice as consultants in occupational medicine in the country. However a subsequent law in 2008 determined that only physicians specialized in occupational medicine could freely practice as consultants in this discipline. The other two categories (consultants in public health medicine and consultants in legal/forensic medicine) were required to undertake additional training (a Master course) to qualify as consultants in occupational medicine.&lt;/p&gt;&lt;p&gt;&lt;b&gt;CONCLUSIONS: &lt;/b&gt;Doctors who entered postgraduate training in public health or legal/forensic medicine before 2008, with the option to practice also as consultants in occupational medicine upon completion of their training, suffered an unprecedented and legally questionable retroactive application of this new law which stripped them of previously acquired rights. Moreover, even after qualifying by undertaking this extra training in occupational medicine, the latter two categories of doctors do not have their training recognized in other member states of the European Union. To disallow the rights of doctors qualified in occupational medicine to work as consultants in the latter medical discipline elsewhere within the European Union seems a clear violation of professional rights and, as such, legal action could be taken to submit this issue to European attention.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><custom1><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/28383611?dopt=Abstract</style></custom1></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Tachmazidou, Ioanna</style></author><author><style face="normal" font="default" size="100%">Süveges, Dániel</style></author><author><style face="normal" font="default" size="100%">Min, Josine L</style></author><author><style face="normal" font="default" size="100%">Ritchie, Graham R S</style></author><author><style face="normal" font="default" size="100%">Steinberg, Julia</style></author><author><style face="normal" font="default" size="100%">Walter, Klaudia</style></author><author><style face="normal" font="default" size="100%">Iotchkova, Valentina</style></author><author><style face="normal" font="default" size="100%">Schwartzentruber, Jeremy</style></author><author><style face="normal" font="default" size="100%">Huang, Jie</style></author><author><style face="normal" font="default" size="100%">Memari, Yasin</style></author><author><style face="normal" font="default" size="100%">McCarthy, Shane</style></author><author><style face="normal" font="default" size="100%">Crawford, Andrew A</style></author><author><style face="normal" font="default" size="100%">Bombieri, Cristina</style></author><author><style face="normal" font="default" size="100%">Cocca, Massimiliano</style></author><author><style face="normal" font="default" size="100%">Farmaki, Aliki-Eleni</style></author><author><style face="normal" font="default" size="100%">Gaunt, Tom R</style></author><author><style face="normal" font="default" size="100%">Jousilahti, Pekka</style></author><author><style face="normal" font="default" size="100%">Kooijman, Marjolein N</style></author><author><style face="normal" font="default" size="100%">Lehne, Benjamin</style></author><author><style face="normal" font="default" size="100%">Malerba, Giovanni</style></author><author><style face="normal" font="default" size="100%">Männistö, Satu</style></author><author><style face="normal" font="default" size="100%">Matchan, Angela</style></author><author><style face="normal" font="default" size="100%">Medina-Gomez, Carolina</style></author><author><style face="normal" font="default" size="100%">Metrustry, Sarah J</style></author><author><style face="normal" font="default" size="100%">Nag, Abhishek</style></author><author><style face="normal" font="default" size="100%">Ntalla, Ioanna</style></author><author><style face="normal" font="default" size="100%">Paternoster, Lavinia</style></author><author><style face="normal" font="default" size="100%">Rayner, Nigel W</style></author><author><style face="normal" font="default" size="100%">Sala, Cinzia</style></author><author><style face="normal" font="default" size="100%">Scott, William R</style></author><author><style face="normal" font="default" size="100%">Shihab, Hashem A</style></author><author><style face="normal" font="default" size="100%">Southam, Lorraine</style></author><author><style face="normal" font="default" size="100%">St Pourcain, Beate</style></author><author><style face="normal" font="default" size="100%">Traglia, Michela</style></author><author><style face="normal" font="default" size="100%">Trajanoska, Katerina</style></author><author><style face="normal" font="default" size="100%">Zaza, Gialuigi</style></author><author><style face="normal" font="default" size="100%">Zhang, Weihua</style></author><author><style face="normal" font="default" size="100%">Artigas, María S</style></author><author><style face="normal" font="default" size="100%">Bansal, Narinder</style></author><author><style face="normal" font="default" size="100%">Benn, Marianne</style></author><author><style face="normal" font="default" size="100%">Chen, Zhongsheng</style></author><author><style face="normal" font="default" size="100%">Danecek, Petr</style></author><author><style face="normal" font="default" size="100%">Lin, Wei-Yu</style></author><author><style face="normal" font="default" size="100%">Locke, Adam</style></author><author><style face="normal" font="default" size="100%">Luan, Jian'an</style></author><author><style face="normal" font="default" size="100%">Manning, Alisa K</style></author><author><style face="normal" font="default" size="100%">Mulas, Antonella</style></author><author><style face="normal" font="default" size="100%">Sidore, Carlo</style></author><author><style face="normal" font="default" size="100%">Tybjaerg-Hansen, Anne</style></author><author><style face="normal" font="default" size="100%">Varbo, Anette</style></author><author><style face="normal" font="default" size="100%">Zoledziewska, Magdalena</style></author><author><style face="normal" font="default" size="100%">Finan, Chris</style></author><author><style face="normal" font="default" size="100%">Hatzikotoulas, Konstantinos</style></author><author><style face="normal" font="default" size="100%">Hendricks, Audrey E</style></author><author><style face="normal" font="default" size="100%">Kemp, John P</style></author><author><style face="normal" font="default" size="100%">Moayyeri, Alireza</style></author><author><style face="normal" font="default" size="100%">Panoutsopoulou, Kalliope</style></author><author><style face="normal" font="default" size="100%">Szpak, Michal</style></author><author><style face="normal" font="default" size="100%">Wilson, Scott G</style></author><author><style face="normal" font="default" size="100%">Boehnke, Michael</style></author><author><style face="normal" font="default" size="100%">Cucca, Francesco</style></author><author><style face="normal" font="default" size="100%">Di Angelantonio, Emanuele</style></author><author><style face="normal" font="default" size="100%">Langenberg, Claudia</style></author><author><style face="normal" font="default" size="100%">Lindgren, Cecilia</style></author><author><style face="normal" font="default" size="100%">McCarthy, Mark I</style></author><author><style face="normal" font="default" size="100%">Morris, Andrew P</style></author><author><style face="normal" font="default" size="100%">Nordestgaard, Børge G</style></author><author><style face="normal" font="default" size="100%">Scott, Robert A</style></author><author><style face="normal" font="default" size="100%">Tobin, Martin D</style></author><author><style face="normal" font="default" size="100%">Wareham, Nicholas J</style></author><author><style face="normal" font="default" size="100%">Burton, Paul</style></author><author><style face="normal" font="default" size="100%">Chambers, John C</style></author><author><style face="normal" font="default" size="100%">Smith, George Davey</style></author><author><style face="normal" font="default" size="100%">Dedoussis, George</style></author><author><style face="normal" font="default" size="100%">Felix, Janine F</style></author><author><style face="normal" font="default" size="100%">Franco, Oscar H</style></author><author><style face="normal" font="default" size="100%">Gambaro, Giovanni</style></author><author><style face="normal" font="default" size="100%">Gasparini, Paolo</style></author><author><style face="normal" font="default" size="100%">Hammond, Christopher J</style></author><author><style face="normal" font="default" size="100%">Hofman, Albert</style></author><author><style face="normal" font="default" size="100%">Jaddoe, Vincent W V</style></author><author><style face="normal" font="default" size="100%">Kleber, Marcus</style></author><author><style face="normal" font="default" size="100%">Kooner, Jaspal S</style></author><author><style face="normal" font="default" size="100%">Perola, Markus</style></author><author><style face="normal" font="default" size="100%">Relton, Caroline</style></author><author><style face="normal" font="default" size="100%">Ring, Susan M</style></author><author><style face="normal" font="default" size="100%">Rivadeneira, Fernando</style></author><author><style face="normal" font="default" size="100%">Salomaa, Veikko</style></author><author><style face="normal" font="default" size="100%">Spector, Timothy D</style></author><author><style face="normal" font="default" size="100%">Stegle, Oliver</style></author><author><style face="normal" font="default" size="100%">Toniolo, Daniela</style></author><author><style face="normal" font="default" size="100%">Uitterlinden, André G</style></author><author><style face="normal" font="default" size="100%">Barroso, Inês</style></author><author><style face="normal" font="default" size="100%">Greenwood, Celia M T</style></author><author><style face="normal" font="default" size="100%">Perry, John R B</style></author><author><style face="normal" font="default" size="100%">Walker, Brian R</style></author><author><style face="normal" font="default" size="100%">Butterworth, Adam S</style></author><author><style face="normal" font="default" size="100%">Xue, Yali</style></author><author><style face="normal" font="default" size="100%">Durbin, Richard</style></author><author><style face="normal" font="default" size="100%">Small, Kerrin S</style></author><author><style face="normal" font="default" size="100%">Soranzo, Nicole</style></author><author><style face="normal" font="default" size="100%">Timpson, Nicholas J</style></author><author><style face="normal" font="default" size="100%">Zeggini, Eleftheria</style></author></authors><translated-authors><author><style face="normal" font="default" size="100%">SpiroMeta Consortium</style></author><author><style face="normal" font="default" size="100%">GoT2D Consortium</style></author><author><style face="normal" font="default" size="100%">arcOGEN Consortium</style></author><author><style face="normal" font="default" size="100%">Understanding Society Scientific group</style></author><author><style face="normal" font="default" size="100%">UK10K Consortium</style></author></translated-authors></contributors><titles><title><style face="normal" font="default" size="100%">Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits.</style></title><secondary-title><style face="normal" font="default" size="100%">Am J Hum Genet</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Am. J. Hum. Genet.</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anthropometry</style></keyword><keyword><style  face="normal" font="default" size="100%">Body Height</style></keyword><keyword><style  face="normal" font="default" size="100%">Cohort Studies</style></keyword><keyword><style  face="normal" font="default" size="100%">Databases, Genetic</style></keyword><keyword><style  face="normal" font="default" size="100%">DNA Methylation</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">Genetic Variation</style></keyword><keyword><style  face="normal" font="default" size="100%">Genome, Human</style></keyword><keyword><style  face="normal" font="default" size="100%">Genome-Wide Association Study</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Lipodystrophy</style></keyword><keyword><style  face="normal" font="default" size="100%">Male</style></keyword><keyword><style  face="normal" font="default" size="100%">Meta-Analysis as Topic</style></keyword><keyword><style  face="normal" font="default" size="100%">Obesity</style></keyword><keyword><style  face="normal" font="default" size="100%">Physical Chromosome Mapping</style></keyword><keyword><style  face="normal" font="default" size="100%">Quantitative Trait Loci</style></keyword><keyword><style  face="normal" font="default" size="100%">Sequence Analysis, DNA</style></keyword><keyword><style  face="normal" font="default" size="100%">Sex Characteristics</style></keyword><keyword><style  face="normal" font="default" size="100%">Syndrome</style></keyword><keyword><style  face="normal" font="default" size="100%">United Kingdom</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2017 Jun 01</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">100</style></volume><pages><style face="normal" font="default" size="100%">865-884</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Deep sequence-based imputation can enhance the discovery power of genome-wide association studies by assessing previously unexplored variation across the common- and low-frequency spectra. We applied a hybrid whole-genome sequencing (WGS) and deep imputation approach to examine the broader allelic architecture of 12 anthropometric traits associated with height, body mass, and fat distribution in up to 267,616 individuals. We report 106 genome-wide significant signals that have not been previously identified, including 9 low-frequency variants pointing to functional candidates. Of the 106 signals, 6 are in genomic regions that have not been implicated with related traits before, 28 are independent signals at previously reported regions, and 72 represent previously reported signals for a different anthropometric trait. 71% of signals reside within genes and fine mapping resolves 23 signals to one or two likely causal variants. We confirm genetic overlap between human monogenic and polygenic anthropometric traits and find signal enrichment in cis expression QTLs in relevant tissues. Our results highlight the potential of WGS strategies to enhance biologically relevant discoveries across the frequency spectrum.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><custom1><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/28552196?dopt=Abstract</style></custom1></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Addobbati, Catarina</style></author><author><style face="normal" font="default" size="100%">De Azevêdo Silva, Jaqueline</style></author><author><style face="normal" font="default" size="100%">A C Tavares, Nathália</style></author><author><style face="normal" font="default" size="100%">Monticielo, Odirlei</style></author><author><style face="normal" font="default" size="100%">M Xavier, Ricardo</style></author><author><style face="normal" font="default" size="100%">T Brenol, João Carlos</style></author><author><style face="normal" font="default" size="100%">Crovella, Sergio</style></author><author><style face="normal" font="default" size="100%">B Chies, José Artur</style></author><author><style face="normal" font="default" size="100%">Sandrin-Garcia, Paula</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Ficolin Gene Polymorphisms in Systemic Lupus Erythematosus and Rheumatoid Arthritis.</style></title><secondary-title><style face="normal" font="default" size="100%">Ann Hum Genet</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Ann. Hum. Genet.</style></alt-title></titles><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2015 Oct 14</style></date></pub-dates></dates><language><style face="normal" font="default" size="100%">ENG</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Systemic lupus erythemathosus (SLE) and rheumatoid arthritis (RA) are complex autoimmune diseases characterized by an immune balance breakdown and by chronic inflammation. Several findings link SLE and RA development with the complement system and ficolin components have emerged as candidates for disease development. Since genetic association studies with ficolin genes in SLE and RA have not yet been conducted in a Brazilian population, the aim of this study was to determine whether polymorphisms of ficolin-1(FCN1) and ficolin-2 (FCN2) genes are associated with SLE and RA susceptibility as well as disease manifestation. Two SNPs within FCN1 (rs2989727 and 1071583) and three in FCN2 (rs17514136, rs3124954, and rs7851696) were studied in 208 SLE and184 RA patients as well as 264 healthy individuals in a Southeast Brazilian population. For SLE patients, the FCN2 rs17514136 SNP was associated with a more severe disease (SLICC) (p = 0.0067). Furthermore, an association between the occurrence of nephritis and the T/T genotype for FCN2 rs3124954 SNP (p = 0.047, OR = 3.17, 95%CI = 1.34-7.5) was observed. No association was observed between the studied polymorphisms and RA development. Thus, our data support involvement of the FCN2 gene in the SLE phenotype.&lt;/p&gt;</style></abstract><custom1><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/26464189?dopt=Abstract</style></custom1></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Haber, Marc</style></author><author><style face="normal" font="default" size="100%">Mezzavilla, Massimo</style></author><author><style face="normal" font="default" size="100%">Xue, Yali</style></author><author><style face="normal" font="default" size="100%">Comas, David</style></author><author><style face="normal" font="default" size="100%">Gasparini, Paolo</style></author><author><style face="normal" font="default" size="100%">Zalloua, Pierre</style></author><author><style face="normal" font="default" size="100%">Tyler-Smith, Chris</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Genetic evidence for an origin of the Armenians from Bronze Age mixing of multiple populations.</style></title><secondary-title><style face="normal" font="default" size="100%">Eur J Hum Genet</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Eur. J. Hum. Genet.</style></alt-title></titles><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2015 Oct 21</style></date></pub-dates></dates><language><style face="normal" font="default" size="100%">ENG</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;The Armenians are a culturally isolated population who historically inhabited a region in the Near East bounded by the Mediterranean and Black seas and the Caucasus, but remain under-represented in genetic studies and have a complex history including a major geographic displacement during World War I. Here, we analyse genome-wide variation in 173 Armenians and compare them with 78 other worldwide populations. We find that Armenians form a distinctive cluster linking the Near East, Europe, and the Caucasus. We show that Armenian diversity can be explained by several mixtures of Eurasian populations that occurred between ~3000 and ~2000 bce, a period characterized by major population migrations after the domestication of the horse, appearance of chariots, and the rise of advanced civilizations in the Near East. However, genetic signals of population mixture cease after ~1200 bce when Bronze Age civilizations in the Eastern Mediterranean world suddenly and violently collapsed. Armenians have since remained isolated and genetic structure within the population developed ~500 years ago when Armenia was divided between the Ottomans and the Safavid Empire in Iran. Finally, we show that Armenians have higher genetic affinity to Neolithic Europeans than other present-day Near Easterners, and that 29% of Armenian ancestry may originate from an ancestral population that is best represented by Neolithic Europeans.European Journal of Human Genetics advance online publication, 21 October 2015; doi:10.1038/ejhg.2015.206.&lt;/p&gt;</style></abstract><custom1><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/26486470?dopt=Abstract</style></custom1></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Noetzli, Leila</style></author><author><style face="normal" font="default" size="100%">Lo, Richard W</style></author><author><style face="normal" font="default" size="100%">Lee-Sherick, Alisa B</style></author><author><style face="normal" font="default" size="100%">Callaghan, Michael</style></author><author><style face="normal" font="default" size="100%">Noris, Patrizia</style></author><author><style face="normal" font="default" size="100%">Savoia, Anna</style></author><author><style face="normal" font="default" size="100%">Rajpurkar, Madhvi</style></author><author><style face="normal" font="default" size="100%">Jones, Kenneth</style></author><author><style face="normal" font="default" size="100%">Gowan, Katherine</style></author><author><style face="normal" font="default" size="100%">Balduini, Carlo L</style></author><author><style face="normal" font="default" size="100%">Pecci, Alessandro</style></author><author><style face="normal" font="default" size="100%">Gnan, Chiara</style></author><author><style face="normal" font="default" size="100%">De Rocco, Daniela</style></author><author><style face="normal" font="default" size="100%">Doubek, Michael</style></author><author><style face="normal" font="default" size="100%">Li, Ling</style></author><author><style face="normal" font="default" size="100%">Lu, Lily</style></author><author><style face="normal" font="default" size="100%">Leung, Richard</style></author><author><style face="normal" font="default" size="100%">Landolt-Marticorena, Carolina</style></author><author><style face="normal" font="default" size="100%">Hunger, Stephen</style></author><author><style face="normal" font="default" size="100%">Heller, Paula</style></author><author><style face="normal" font="default" size="100%">Gutierrez-Hartmann, Arthur</style></author><author><style face="normal" font="default" size="100%">Xiayuan, Liang</style></author><author><style face="normal" font="default" size="100%">Pluthero, Fred G</style></author><author><style face="normal" font="default" size="100%">Rowley, Jesse W</style></author><author><style face="normal" font="default" size="100%">Weyrich, Andrew S</style></author><author><style face="normal" font="default" size="100%">Kahr, Walter H A</style></author><author><style face="normal" font="default" size="100%">Porter, Christopher C</style></author><author><style face="normal" font="default" size="100%">Di Paola, Jorge</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Germline mutations in ETV6 are associated with thrombocytopenia, red cell macrocytosis and predisposition to lymphoblastic leukemia.</style></title><secondary-title><style face="normal" font="default" size="100%">Nat Genet</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Nat. Genet.</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Adult</style></keyword><keyword><style  face="normal" font="default" size="100%">Child, Preschool</style></keyword><keyword><style  face="normal" font="default" size="100%">DNA Mutational Analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Erythrocytes, Abnormal</style></keyword><keyword><style  face="normal" font="default" size="100%">Exome</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">Genetic Association Studies</style></keyword><keyword><style  face="normal" font="default" size="100%">Genetic Predisposition to Disease</style></keyword><keyword><style  face="normal" font="default" size="100%">Germ-Line Mutation</style></keyword><keyword><style  face="normal" font="default" size="100%">HEK293 Cells</style></keyword><keyword><style  face="normal" font="default" size="100%">Hematologic Diseases</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Male</style></keyword><keyword><style  face="normal" font="default" size="100%">Mutation, Missense</style></keyword><keyword><style  face="normal" font="default" size="100%">Pedigree</style></keyword><keyword><style  face="normal" font="default" size="100%">Precursor Cell Lymphoblastic Leukemia-Lymphoma</style></keyword><keyword><style  face="normal" font="default" size="100%">Proto-Oncogene Proteins c-ets</style></keyword><keyword><style  face="normal" font="default" size="100%">Repressor Proteins</style></keyword><keyword><style  face="normal" font="default" size="100%">Thrombocytopenia</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2015 May</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">47</style></volume><pages><style face="normal" font="default" size="100%">535-8</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Some familial platelet disorders are associated with predisposition to leukemia, myelodysplastic syndrome (MDS) or dyserythropoietic anemia. We identified a family with autosomal dominant thrombocytopenia, high erythrocyte mean corpuscular volume (MCV) and two occurrences of B cell-precursor acute lymphoblastic leukemia (ALL). Whole-exome sequencing identified a heterozygous single-nucleotide change in ETV6 (ets variant 6), c.641C&gt;T, encoding a p.Pro214Leu substitution in the central domain, segregating with thrombocytopenia and elevated MCV. A screen of 23 families with similar phenotypes identified 2 with ETV6 mutations. One family also had a mutation encoding p.Pro214Leu and one individual with ALL. The other family had a c.1252A&gt;G transition producing a p.Arg418Gly substitution in the DNA-binding domain, with alternative splicing and exon skipping. Functional characterization of these mutations showed aberrant cellular localization of mutant and endogenous ETV6, decreased transcriptional repression and altered megakaryocyte maturation. Our findings underscore a key role for ETV6 in platelet formation and leukemia predisposition.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><custom1><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/25807284?dopt=Abstract</style></custom1></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Forouzanfar, Mohammad H</style></author><author><style face="normal" font="default" size="100%">Alexander, Lily</style></author><author><style face="normal" font="default" size="100%">Anderson, H Ross</style></author><author><style face="normal" font="default" size="100%">Bachman, Victoria F</style></author><author><style face="normal" font="default" size="100%">Biryukov, Stan</style></author><author><style face="normal" font="default" size="100%">Brauer, Michael</style></author><author><style face="normal" font="default" size="100%">Burnett, Richard</style></author><author><style face="normal" font="default" size="100%">Casey, Daniel</style></author><author><style face="normal" font="default" size="100%">Coates, Matthew M</style></author><author><style face="normal" font="default" size="100%">Cohen, Aaron</style></author><author><style face="normal" font="default" size="100%">Delwiche, Kristen</style></author><author><style face="normal" font="default" size="100%">Estep, Kara</style></author><author><style face="normal" font="default" size="100%">Frostad, Joseph J</style></author><author><style face="normal" font="default" size="100%">Astha, K C</style></author><author><style face="normal" font="default" size="100%">Kyu, Hmwe H</style></author><author><style face="normal" font="default" size="100%">Moradi-Lakeh, Maziar</style></author><author><style face="normal" font="default" size="100%">Ng, Marie</style></author><author><style face="normal" font="default" size="100%">Slepak, Erica Leigh</style></author><author><style face="normal" font="default" size="100%">Thomas, Bernadette A</style></author><author><style face="normal" font="default" size="100%">Wagner, Joseph</style></author><author><style face="normal" font="default" size="100%">Aasvang, Gunn Marit</style></author><author><style face="normal" font="default" size="100%">Abbafati, Cristiana</style></author><author><style face="normal" font="default" size="100%">Abbasoglu Ozgoren, Ayse</style></author><author><style face="normal" font="default" size="100%">Abd-Allah, Foad</style></author><author><style face="normal" font="default" size="100%">Abera, Semaw F</style></author><author><style face="normal" font="default" size="100%">Aboyans, Victor</style></author><author><style face="normal" font="default" size="100%">Abraham, Biju</style></author><author><style face="normal" font="default" size="100%">Abraham, Jerry Puthenpurakal</style></author><author><style face="normal" font="default" size="100%">Abubakar, Ibrahim</style></author><author><style face="normal" font="default" size="100%">Abu-Rmeileh, Niveen M E</style></author><author><style face="normal" font="default" size="100%">Aburto, Tania C</style></author><author><style face="normal" font="default" size="100%">Achoki, Tom</style></author><author><style face="normal" font="default" size="100%">Adelekan, Ademola</style></author><author><style face="normal" font="default" size="100%">Adofo, Koranteng</style></author><author><style face="normal" font="default" size="100%">Adou, Arsène K</style></author><author><style face="normal" font="default" size="100%">Adsuar, José C</style></author><author><style face="normal" font="default" size="100%">Afshin, Ashkan</style></author><author><style face="normal" font="default" size="100%">Agardh, Emilie E</style></author><author><style face="normal" font="default" size="100%">Al Khabouri, Mazin J</style></author><author><style face="normal" font="default" size="100%">Al Lami, Faris H</style></author><author><style face="normal" font="default" size="100%">Alam, Sayed Saidul</style></author><author><style face="normal" font="default" size="100%">Alasfoor, Deena</style></author><author><style face="normal" font="default" size="100%">Albittar, Mohammed I</style></author><author><style face="normal" font="default" size="100%">Alegretti, Miguel A</style></author><author><style face="normal" font="default" size="100%">Aleman, Alicia V</style></author><author><style face="normal" font="default" size="100%">Alemu, Zewdie A</style></author><author><style face="normal" font="default" size="100%">Alfonso-Cristancho, Rafael</style></author><author><style face="normal" font="default" size="100%">Alhabib, Samia</style></author><author><style face="normal" font="default" size="100%">Ali, Raghib</style></author><author><style face="normal" font="default" size="100%">Ali, Mohammed K</style></author><author><style face="normal" font="default" size="100%">Alla, François</style></author><author><style face="normal" font="default" size="100%">Allebeck, Peter</style></author><author><style face="normal" font="default" size="100%">Allen, Peter J</style></author><author><style face="normal" font="default" size="100%">Alsharif, Ubai</style></author><author><style face="normal" font="default" size="100%">Alvarez, Elena</style></author><author><style face="normal" font="default" size="100%">Alvis-Guzmán, Nelson</style></author><author><style face="normal" font="default" size="100%">Amankwaa, Adansi A</style></author><author><style face="normal" font="default" size="100%">Amare, Azmeraw T</style></author><author><style face="normal" font="default" size="100%">Ameh, Emmanuel A</style></author><author><style face="normal" font="default" size="100%">Ameli, Omid</style></author><author><style face="normal" font="default" size="100%">Amini, Heresh</style></author><author><style face="normal" font="default" size="100%">Ammar, Walid</style></author><author><style face="normal" font="default" size="100%">Anderson, Benjamin O</style></author><author><style face="normal" font="default" size="100%">Antonio, Carl Abelardo T</style></author><author><style face="normal" font="default" size="100%">Anwari, Palwasha</style></author><author><style face="normal" font="default" size="100%">Argeseanu Cunningham, Solveig</style></author><author><style face="normal" font="default" size="100%">Arnlöv, Johan</style></author><author><style face="normal" font="default" size="100%">Arsenijevic, Valentina S Arsic</style></author><author><style face="normal" font="default" size="100%">Artaman, Al</style></author><author><style face="normal" font="default" size="100%">Asghar, Rana J</style></author><author><style face="normal" font="default" size="100%">Assadi, Reza</style></author><author><style face="normal" font="default" size="100%">Atkins, Lydia S</style></author><author><style face="normal" font="default" size="100%">Atkinson, Charles</style></author><author><style face="normal" font="default" size="100%">Avila, Marco A</style></author><author><style face="normal" font="default" size="100%">Awuah, Baffour</style></author><author><style face="normal" font="default" size="100%">Badawi, Alaa</style></author><author><style face="normal" font="default" size="100%">Bahit, Maria C</style></author><author><style face="normal" font="default" size="100%">Bakfalouni, Talal</style></author><author><style face="normal" font="default" size="100%">Balakrishnan, Kalpana</style></author><author><style face="normal" font="default" size="100%">Balalla, Shivanthi</style></author><author><style face="normal" font="default" size="100%">Balu, Ravi Kumar</style></author><author><style face="normal" font="default" size="100%">Banerjee, Amitava</style></author><author><style face="normal" font="default" size="100%">Barber, Ryan M</style></author><author><style face="normal" font="default" size="100%">Barker-Collo, Suzanne L</style></author><author><style face="normal" font="default" size="100%">Barquera, Simon</style></author><author><style face="normal" font="default" size="100%">Barregard, Lars</style></author><author><style face="normal" font="default" size="100%">Barrero, Lope H</style></author><author><style face="normal" font="default" size="100%">Barrientos-Gutierrez, Tonatiuh</style></author><author><style face="normal" font="default" size="100%">Basto-Abreu, Ana C</style></author><author><style face="normal" font="default" size="100%">Basu, Arindam</style></author><author><style face="normal" font="default" size="100%">Basu, Sanjay</style></author><author><style face="normal" font="default" size="100%">Basulaiman, Mohammed O</style></author><author><style face="normal" font="default" size="100%">Batis Ruvalcaba, Carolina</style></author><author><style face="normal" font="default" size="100%">Beardsley, Justin</style></author><author><style face="normal" font="default" size="100%">Bedi, Neeraj</style></author><author><style face="normal" font="default" size="100%">Bekele, Tolesa</style></author><author><style face="normal" font="default" size="100%">Bell, Michelle L</style></author><author><style face="normal" font="default" size="100%">Benjet, Corina</style></author><author><style face="normal" font="default" size="100%">Bennett, Derrick A</style></author><author><style face="normal" font="default" size="100%">Benzian, Habib</style></author><author><style face="normal" font="default" size="100%">Bernabe, Eduardo</style></author><author><style face="normal" font="default" size="100%">Beyene, Tariku J</style></author><author><style face="normal" font="default" size="100%">Bhala, Neeraj</style></author><author><style face="normal" font="default" size="100%">Bhalla, Ashish</style></author><author><style face="normal" font="default" size="100%">Bhutta, Zulfiqar A</style></author><author><style face="normal" font="default" size="100%">Bikbov, Boris</style></author><author><style face="normal" font="default" size="100%">Bin Abdulhak, Aref A</style></author><author><style face="normal" font="default" size="100%">Blore, Jed D</style></author><author><style face="normal" font="default" size="100%">Blyth, Fiona M</style></author><author><style face="normal" font="default" size="100%">Bohensky, Megan A</style></author><author><style face="normal" font="default" size="100%">Bora Başara, Berrak</style></author><author><style face="normal" font="default" size="100%">Borges, Guilherme</style></author><author><style face="normal" font="default" size="100%">Bornstein, Natan M</style></author><author><style face="normal" font="default" size="100%">Bose, Dipan</style></author><author><style face="normal" font="default" size="100%">Boufous, Soufiane</style></author><author><style face="normal" font="default" size="100%">Bourne, Rupert R</style></author><author><style face="normal" font="default" size="100%">Brainin, Michael</style></author><author><style face="normal" font="default" size="100%">Brazinova, Alexandra</style></author><author><style face="normal" font="default" size="100%">Breitborde, Nicholas J</style></author><author><style face="normal" font="default" size="100%">Brenner, Hermann</style></author><author><style face="normal" font="default" size="100%">Briggs, Adam D M</style></author><author><style face="normal" font="default" size="100%">Broday, David M</style></author><author><style face="normal" font="default" size="100%">Brooks, Peter M</style></author><author><style face="normal" font="default" size="100%">Bruce, Nigel G</style></author><author><style face="normal" font="default" size="100%">Brugha, Traolach S</style></author><author><style face="normal" font="default" size="100%">Brunekreef, Bert</style></author><author><style face="normal" font="default" size="100%">Buchbinder, Rachelle</style></author><author><style face="normal" font="default" size="100%">Bui, Linh N</style></author><author><style face="normal" font="default" size="100%">Bukhman, Gene</style></author><author><style face="normal" font="default" size="100%">Bulloch, Andrew G</style></author><author><style face="normal" font="default" size="100%">Burch, Michael</style></author><author><style face="normal" font="default" size="100%">Burney, Peter G J</style></author><author><style face="normal" font="default" size="100%">Campos-Nonato, Ismael R</style></author><author><style face="normal" font="default" size="100%">Campuzano, Julio C</style></author><author><style face="normal" font="default" size="100%">Cantoral, Alejandra J</style></author><author><style face="normal" font="default" size="100%">Caravanos, Jack</style></author><author><style face="normal" font="default" size="100%">Cárdenas, Rosario</style></author><author><style face="normal" font="default" size="100%">Cardis, Elisabeth</style></author><author><style face="normal" font="default" size="100%">Carpenter, David O</style></author><author><style face="normal" font="default" size="100%">Caso, Valeria</style></author><author><style face="normal" font="default" size="100%">Castañeda-Orjuela, Carlos A</style></author><author><style face="normal" font="default" size="100%">Castro, Ruben E</style></author><author><style face="normal" font="default" size="100%">Catalá-López, Ferrán</style></author><author><style face="normal" font="default" size="100%">Cavalleri, Fiorella</style></author><author><style face="normal" font="default" size="100%">Cavlin, Alanur</style></author><author><style face="normal" font="default" size="100%">Chadha, Vineet K</style></author><author><style face="normal" font="default" size="100%">Chang, Jung-Chen</style></author><author><style face="normal" font="default" size="100%">Charlson, Fiona J</style></author><author><style face="normal" font="default" size="100%">Chen, Honglei</style></author><author><style face="normal" font="default" size="100%">Chen, Wanqing</style></author><author><style face="normal" font="default" size="100%">Chen, Zhengming</style></author><author><style face="normal" font="default" size="100%">Chiang, Peggy P</style></author><author><style face="normal" font="default" size="100%">Chimed-Ochir, Odgerel</style></author><author><style face="normal" font="default" size="100%">Chowdhury, Rajiv</style></author><author><style face="normal" font="default" size="100%">Christophi, Costas A</style></author><author><style face="normal" font="default" size="100%">Chuang, Ting-Wu</style></author><author><style face="normal" font="default" size="100%">Chugh, Sumeet S</style></author><author><style face="normal" font="default" size="100%">Cirillo, Massimo</style></author><author><style face="normal" font="default" size="100%">Claßen, Thomas K D</style></author><author><style face="normal" font="default" size="100%">Colistro, Valentina</style></author><author><style face="normal" font="default" size="100%">Colomar, Mercedes</style></author><author><style face="normal" font="default" size="100%">Colquhoun, Samantha M</style></author><author><style face="normal" font="default" size="100%">Contreras, Alejandra G</style></author><author><style face="normal" font="default" size="100%">Cooper, Cyrus</style></author><author><style face="normal" font="default" size="100%">Cooperrider, Kimberly</style></author><author><style face="normal" font="default" size="100%">Cooper, Leslie T</style></author><author><style face="normal" font="default" size="100%">Coresh, Josef</style></author><author><style face="normal" font="default" size="100%">Courville, Karen J</style></author><author><style face="normal" font="default" size="100%">Criqui, Michael H</style></author><author><style face="normal" font="default" size="100%">Cuevas-Nasu, Lucia</style></author><author><style face="normal" font="default" size="100%">Damsere-Derry, James</style></author><author><style face="normal" font="default" size="100%">Danawi, Hadi</style></author><author><style face="normal" font="default" size="100%">Dandona, Lalit</style></author><author><style face="normal" font="default" size="100%">Dandona, Rakhi</style></author><author><style face="normal" font="default" size="100%">Dargan, Paul I</style></author><author><style face="normal" font="default" size="100%">Davis, Adrian</style></author><author><style face="normal" font="default" size="100%">Davitoiu, Dragos V</style></author><author><style face="normal" font="default" size="100%">Dayama, Anand</style></author><author><style face="normal" font="default" size="100%">de Castro, E Filipa</style></author><author><style face="normal" font="default" size="100%">De la Cruz-Góngora, Vanessa</style></author><author><style face="normal" font="default" size="100%">De Leo, Diego</style></author><author><style face="normal" font="default" size="100%">de Lima, Graça</style></author><author><style face="normal" font="default" size="100%">Degenhardt, Louisa</style></author><author><style face="normal" font="default" size="100%">del Pozo-Cruz, Borja</style></author><author><style face="normal" font="default" size="100%">Dellavalle, Robert P</style></author><author><style face="normal" font="default" size="100%">Deribe, Kebede</style></author><author><style face="normal" font="default" size="100%">Derrett, Sarah</style></author><author><style face="normal" font="default" size="100%">Des Jarlais, Don C</style></author><author><style face="normal" font="default" size="100%">Dessalegn, Muluken</style></author><author><style face="normal" font="default" size="100%">deVeber, Gabrielle A</style></author><author><style face="normal" font="default" size="100%">Devries, Karen M</style></author><author><style face="normal" font="default" size="100%">Dharmaratne, Samath D</style></author><author><style face="normal" font="default" size="100%">Dherani, Mukesh K</style></author><author><style face="normal" font="default" size="100%">Dicker, Daniel</style></author><author><style face="normal" font="default" size="100%">Ding, Eric L</style></author><author><style face="normal" font="default" size="100%">Dokova, Klara</style></author><author><style face="normal" font="default" size="100%">Dorsey, E Ray</style></author><author><style face="normal" font="default" size="100%">Driscoll, Tim R</style></author><author><style face="normal" font="default" size="100%">Duan, Leilei</style></author><author><style face="normal" font="default" size="100%">Durrani, Adnan M</style></author><author><style face="normal" font="default" size="100%">Ebel, Beth E</style></author><author><style face="normal" font="default" size="100%">Ellenbogen, Richard G</style></author><author><style face="normal" font="default" size="100%">Elshrek, Yousef M</style></author><author><style face="normal" font="default" size="100%">Endres, Matthias</style></author><author><style face="normal" font="default" size="100%">Ermakov, Sergey P</style></author><author><style face="normal" font="default" size="100%">Erskine, Holly E</style></author><author><style face="normal" font="default" size="100%">Eshrati, Babak</style></author><author><style face="normal" font="default" size="100%">Esteghamati, Alireza</style></author><author><style face="normal" font="default" size="100%">Fahimi, Saman</style></author><author><style face="normal" font="default" size="100%">Faraon, Emerito Jose A</style></author><author><style face="normal" font="default" size="100%">Farzadfar, Farshad</style></author><author><style face="normal" font="default" size="100%">Fay, Derek F J</style></author><author><style face="normal" font="default" size="100%">Feigin, Valery L</style></author><author><style face="normal" font="default" size="100%">Feigl, Andrea B</style></author><author><style face="normal" font="default" size="100%">Fereshtehnejad, Seyed-Mohammad</style></author><author><style face="normal" font="default" size="100%">Ferrari, Alize J</style></author><author><style face="normal" font="default" size="100%">Ferri, Cleusa P</style></author><author><style face="normal" font="default" size="100%">Flaxman, Abraham D</style></author><author><style face="normal" font="default" size="100%">Fleming, Thomas D</style></author><author><style face="normal" font="default" size="100%">Foigt, Nataliya</style></author><author><style face="normal" font="default" size="100%">Foreman, Kyle J</style></author><author><style face="normal" font="default" size="100%">Paleo, Urbano Fra</style></author><author><style face="normal" font="default" size="100%">Franklin, Richard C</style></author><author><style face="normal" font="default" size="100%">Gabbe, Belinda</style></author><author><style face="normal" font="default" size="100%">Gaffikin, Lynne</style></author><author><style face="normal" font="default" size="100%">Gakidou, Emmanuela</style></author><author><style face="normal" font="default" size="100%">Gamkrelidze, Amiran</style></author><author><style face="normal" font="default" size="100%">Gankpé, Fortuné G</style></author><author><style face="normal" font="default" size="100%">Gansevoort, Ron T</style></author><author><style face="normal" font="default" size="100%">García-Guerra, Francisco A</style></author><author><style face="normal" font="default" size="100%">Gasana, Evariste</style></author><author><style face="normal" font="default" size="100%">Geleijnse, Johanna M</style></author><author><style face="normal" font="default" size="100%">Gessner, Bradford D</style></author><author><style face="normal" font="default" size="100%">Gething, Pete</style></author><author><style face="normal" font="default" size="100%">Gibney, Katherine B</style></author><author><style face="normal" font="default" size="100%">Gillum, Richard F</style></author><author><style face="normal" font="default" size="100%">Ginawi, Ibrahim A M</style></author><author><style face="normal" font="default" size="100%">Giroud, Maurice</style></author><author><style face="normal" font="default" size="100%">Giussani, Giorgia</style></author><author><style face="normal" font="default" size="100%">Goenka, Shifalika</style></author><author><style face="normal" font="default" size="100%">Goginashvili, Ketevan</style></author><author><style face="normal" font="default" size="100%">Gomez Dantes, Hector</style></author><author><style face="normal" font="default" size="100%">Gona, Philimon</style></author><author><style face="normal" font="default" size="100%">Gonzalez de Cosio, Teresita</style></author><author><style face="normal" font="default" size="100%">González-Castell, Dinorah</style></author><author><style face="normal" font="default" size="100%">Gotay, Carolyn C</style></author><author><style face="normal" font="default" size="100%">Goto, Atsushi</style></author><author><style face="normal" font="default" size="100%">Gouda, Hebe N</style></author><author><style face="normal" font="default" size="100%">Guerrant, Richard L</style></author><author><style face="normal" font="default" size="100%">Gugnani, Harish C</style></author><author><style face="normal" font="default" size="100%">Guillemin, Francis</style></author><author><style face="normal" font="default" size="100%">Gunnell, David</style></author><author><style face="normal" font="default" size="100%">Gupta, Rahul</style></author><author><style face="normal" font="default" size="100%">Gupta, Rajeev</style></author><author><style face="normal" font="default" size="100%">Gutiérrez, Reyna A</style></author><author><style face="normal" font="default" size="100%">Hafezi-Nejad, Nima</style></author><author><style face="normal" font="default" size="100%">Hagan, Holly</style></author><author><style face="normal" font="default" size="100%">Hagstromer, Maria</style></author><author><style face="normal" font="default" size="100%">Halasa, Yara A</style></author><author><style face="normal" font="default" size="100%">Hamadeh, Randah R</style></author><author><style face="normal" font="default" size="100%">Hammami, Mouhanad</style></author><author><style face="normal" font="default" size="100%">Hankey, Graeme J</style></author><author><style face="normal" font="default" size="100%">Hao, Yuantao</style></author><author><style face="normal" font="default" size="100%">Harb, Hilda L</style></author><author><style face="normal" font="default" size="100%">Haregu, Tilahun Nigatu</style></author><author><style face="normal" font="default" size="100%">Haro, Josep Maria</style></author><author><style face="normal" font="default" size="100%">Havmoeller, Rasmus</style></author><author><style face="normal" font="default" size="100%">Hay, Simon I</style></author><author><style face="normal" font="default" size="100%">Hedayati, Mohammad T</style></author><author><style face="normal" font="default" size="100%">Heredia-Pi, Ileana B</style></author><author><style face="normal" font="default" size="100%">Hernandez, Lucia</style></author><author><style face="normal" font="default" size="100%">Heuton, Kyle R</style></author><author><style face="normal" font="default" size="100%">Heydarpour, Pouria</style></author><author><style face="normal" font="default" size="100%">Hijar, Martha</style></author><author><style face="normal" font="default" size="100%">Hoek, Hans W</style></author><author><style face="normal" font="default" size="100%">Hoffman, Howard J</style></author><author><style face="normal" font="default" size="100%">Hornberger, John C</style></author><author><style face="normal" font="default" size="100%">Hosgood, H Dean</style></author><author><style face="normal" font="default" size="100%">Hoy, Damian G</style></author><author><style face="normal" font="default" size="100%">Hsairi, Mohamed</style></author><author><style face="normal" font="default" size="100%">Hu, Guoqing</style></author><author><style face="normal" font="default" size="100%">Hu, Howard</style></author><author><style face="normal" font="default" size="100%">Huang, Cheng</style></author><author><style face="normal" font="default" size="100%">Huang, John J</style></author><author><style face="normal" font="default" size="100%">Hubbell, Bryan J</style></author><author><style face="normal" font="default" size="100%">Huiart, Laetitia</style></author><author><style face="normal" font="default" size="100%">Husseini, Abdullatif</style></author><author><style face="normal" font="default" size="100%">Iannarone, Marissa L</style></author><author><style face="normal" font="default" size="100%">Iburg, Kim M</style></author><author><style face="normal" font="default" size="100%">Idrisov, Bulat T</style></author><author><style face="normal" font="default" size="100%">Ikeda, Nayu</style></author><author><style face="normal" font="default" size="100%">Innos, Kaire</style></author><author><style face="normal" font="default" size="100%">Inoue, Manami</style></author><author><style face="normal" font="default" size="100%">Islami, Farhad</style></author><author><style face="normal" font="default" size="100%">Ismayilova, Samaya</style></author><author><style face="normal" font="default" size="100%">Jacobsen, Kathryn H</style></author><author><style face="normal" font="default" size="100%">Jansen, Henrica A</style></author><author><style face="normal" font="default" size="100%">Jarvis, Deborah L</style></author><author><style face="normal" font="default" size="100%">Jassal, Simerjot K</style></author><author><style face="normal" font="default" size="100%">Jauregui, Alejandra</style></author><author><style face="normal" font="default" size="100%">Jayaraman, Sudha</style></author><author><style face="normal" font="default" size="100%">Jeemon, Panniyammakal</style></author><author><style face="normal" font="default" size="100%">Jensen, Paul N</style></author><author><style face="normal" font="default" size="100%">Jha, Vivekanand</style></author><author><style face="normal" font="default" size="100%">Jiang, Fan</style></author><author><style face="normal" font="default" size="100%">Jiang, Guohong</style></author><author><style face="normal" font="default" size="100%">Jiang, Ying</style></author><author><style face="normal" font="default" size="100%">Jonas, Jost B</style></author><author><style face="normal" font="default" size="100%">Juel, Knud</style></author><author><style face="normal" font="default" size="100%">Kan, Haidong</style></author><author><style face="normal" font="default" size="100%">Kany Roseline, Sidibe S</style></author><author><style face="normal" font="default" size="100%">Karam, Nadim E</style></author><author><style face="normal" font="default" size="100%">Karch, André</style></author><author><style face="normal" font="default" size="100%">Karema, Corine K</style></author><author><style face="normal" font="default" size="100%">Karthikeyan, Ganesan</style></author><author><style face="normal" font="default" size="100%">Kaul, Anil</style></author><author><style face="normal" font="default" size="100%">Kawakami, Norito</style></author><author><style face="normal" font="default" size="100%">Kazi, Dhruv S</style></author><author><style face="normal" font="default" size="100%">Kemp, Andrew H</style></author><author><style face="normal" font="default" size="100%">Kengne, Andre P</style></author><author><style face="normal" font="default" size="100%">Keren, Andre</style></author><author><style face="normal" font="default" size="100%">Khader, Yousef S</style></author><author><style face="normal" font="default" size="100%">Khalifa, Shams Eldin Ali Hassan</style></author><author><style face="normal" font="default" size="100%">Khan, Ejaz A</style></author><author><style face="normal" font="default" size="100%">Khang, Young-Ho</style></author><author><style face="normal" font="default" size="100%">Khatibzadeh, Shahab</style></author><author><style face="normal" font="default" size="100%">Khonelidze, Irma</style></author><author><style face="normal" font="default" size="100%">Kieling, Christian</style></author><author><style face="normal" font="default" size="100%">Kim, Daniel</style></author><author><style face="normal" font="default" size="100%">Kim, Sungroul</style></author><author><style face="normal" font="default" size="100%">Kim, Yunjin</style></author><author><style face="normal" font="default" size="100%">Kimokoti, Ruth W</style></author><author><style face="normal" font="default" size="100%">Kinfu, Yohannes</style></author><author><style face="normal" font="default" size="100%">Kinge, Jonas M</style></author><author><style face="normal" font="default" size="100%">Kissela, Brett M</style></author><author><style face="normal" font="default" size="100%">Kivipelto, Miia</style></author><author><style face="normal" font="default" size="100%">Knibbs, Luke D</style></author><author><style face="normal" font="default" size="100%">Knudsen, Ann Kristin</style></author><author><style face="normal" font="default" size="100%">Kokubo, Yoshihiro</style></author><author><style face="normal" font="default" size="100%">Kose, M Rifat</style></author><author><style face="normal" font="default" size="100%">Kosen, Soewarta</style></author><author><style face="normal" font="default" size="100%">Kraemer, Alexander</style></author><author><style face="normal" font="default" size="100%">Kravchenko, Michael</style></author><author><style face="normal" font="default" size="100%">Krishnaswami, Sanjay</style></author><author><style face="normal" font="default" size="100%">Kromhout, Hans</style></author><author><style face="normal" font="default" size="100%">Ku, Tiffany</style></author><author><style face="normal" font="default" size="100%">Kuate Defo, Barthelemy</style></author><author><style face="normal" font="default" size="100%">Kucuk Bicer, Burcu</style></author><author><style face="normal" font="default" size="100%">Kuipers, Ernst J</style></author><author><style face="normal" font="default" size="100%">Kulkarni, Chanda</style></author><author><style face="normal" font="default" size="100%">Kulkarni, Veena S</style></author><author><style face="normal" font="default" size="100%">Kumar, G Anil</style></author><author><style face="normal" font="default" size="100%">Kwan, Gene F</style></author><author><style face="normal" font="default" size="100%">Lai, Taavi</style></author><author><style face="normal" font="default" size="100%">Lakshmana Balaji, Arjun</style></author><author><style face="normal" font="default" size="100%">Lalloo, Ratilal</style></author><author><style face="normal" font="default" size="100%">Lallukka, Tea</style></author><author><style face="normal" font="default" size="100%">Lam, Hilton</style></author><author><style face="normal" font="default" size="100%">Lan, Qing</style></author><author><style face="normal" font="default" size="100%">Lansingh, Van C</style></author><author><style face="normal" font="default" size="100%">Larson, Heidi J</style></author><author><style face="normal" font="default" size="100%">Larsson, Anders</style></author><author><style face="normal" font="default" size="100%">Laryea, Dennis O</style></author><author><style face="normal" font="default" size="100%">Lavados, Pablo M</style></author><author><style face="normal" font="default" size="100%">Lawrynowicz, Alicia E</style></author><author><style face="normal" font="default" size="100%">Leasher, Janet L</style></author><author><style face="normal" font="default" size="100%">Lee, Jong-Tae</style></author><author><style face="normal" font="default" size="100%">Leigh, James</style></author><author><style face="normal" font="default" size="100%">Leung, Ricky</style></author><author><style face="normal" font="default" size="100%">Levi, Miriam</style></author><author><style face="normal" font="default" size="100%">Li, Yichong</style></author><author><style face="normal" font="default" size="100%">Li, Yongmei</style></author><author><style face="normal" font="default" size="100%">Liang, Juan</style></author><author><style face="normal" font="default" size="100%">Liang, Xiaofeng</style></author><author><style face="normal" font="default" size="100%">Lim, Stephen S</style></author><author><style face="normal" font="default" size="100%">Lindsay, M Patrice</style></author><author><style face="normal" font="default" size="100%">Lipshultz, Steven E</style></author><author><style face="normal" font="default" size="100%">Liu, Shiwei</style></author><author><style face="normal" font="default" size="100%">Liu, Yang</style></author><author><style face="normal" font="default" size="100%">Lloyd, Belinda K</style></author><author><style face="normal" font="default" size="100%">Logroscino, Giancarlo</style></author><author><style face="normal" font="default" size="100%">London, Stephanie J</style></author><author><style face="normal" font="default" size="100%">Lopez, Nancy</style></author><author><style face="normal" font="default" size="100%">Lortet-Tieulent, Joannie</style></author><author><style face="normal" font="default" size="100%">Lotufo, Paulo A</style></author><author><style face="normal" font="default" size="100%">Lozano, Rafael</style></author><author><style face="normal" font="default" size="100%">Lunevicius, Raimundas</style></author><author><style face="normal" font="default" size="100%">Ma, Jixiang</style></author><author><style face="normal" font="default" size="100%">Ma, Stefan</style></author><author><style face="normal" font="default" size="100%">Machado, Vasco M P</style></author><author><style face="normal" font="default" size="100%">MacIntyre, Michael F</style></author><author><style face="normal" font="default" size="100%">Magis-Rodriguez, Carlos</style></author><author><style face="normal" font="default" size="100%">Mahdi, Abbas A</style></author><author><style face="normal" font="default" size="100%">Majdan, Marek</style></author><author><style face="normal" font="default" size="100%">Malekzadeh, Reza</style></author><author><style face="normal" font="default" size="100%">Mangalam, Srikanth</style></author><author><style face="normal" font="default" size="100%">Mapoma, Christopher C</style></author><author><style face="normal" font="default" size="100%">Marape, Marape</style></author><author><style face="normal" font="default" size="100%">Marcenes, Wagner</style></author><author><style face="normal" font="default" size="100%">Margolis, David J</style></author><author><style face="normal" font="default" size="100%">Margono, Christopher</style></author><author><style face="normal" font="default" size="100%">Marks, Guy B</style></author><author><style face="normal" font="default" size="100%">Martin, Randall V</style></author><author><style face="normal" font="default" size="100%">Marzan, Melvin B</style></author><author><style face="normal" font="default" size="100%">Mashal, Mohammad T</style></author><author><style face="normal" font="default" size="100%">Masiye, Felix</style></author><author><style face="normal" font="default" size="100%">Mason-Jones, Amanda J</style></author><author><style face="normal" font="default" size="100%">Matsushita, Kunihiro</style></author><author><style face="normal" font="default" size="100%">Matzopoulos, Richard</style></author><author><style face="normal" font="default" size="100%">Mayosi, Bongani M</style></author><author><style face="normal" font="default" size="100%">Mazorodze, Tasara T</style></author><author><style face="normal" font="default" size="100%">McKay, Abigail C</style></author><author><style face="normal" font="default" size="100%">McKee, Martin</style></author><author><style face="normal" font="default" size="100%">McLain, Abigail</style></author><author><style face="normal" font="default" size="100%">Meaney, Peter A</style></author><author><style face="normal" font="default" size="100%">Medina, Catalina</style></author><author><style face="normal" font="default" size="100%">Mehndiratta, Man Mohan</style></author><author><style face="normal" font="default" size="100%">Mejia-Rodriguez, Fabiola</style></author><author><style face="normal" font="default" size="100%">Mekonnen, Wubegzier</style></author><author><style face="normal" font="default" size="100%">Melaku, Yohannes A</style></author><author><style face="normal" font="default" size="100%">Meltzer, Michele</style></author><author><style face="normal" font="default" size="100%">Memish, Ziad A</style></author><author><style face="normal" font="default" size="100%">Mendoza, Walter</style></author><author><style face="normal" font="default" size="100%">Mensah, George A</style></author><author><style face="normal" font="default" size="100%">Meretoja, Atte</style></author><author><style face="normal" font="default" size="100%">Mhimbira, Francis Apolinary</style></author><author><style face="normal" font="default" size="100%">Micha, Renata</style></author><author><style face="normal" font="default" size="100%">Miller, Ted R</style></author><author><style face="normal" font="default" size="100%">Mills, Edward J</style></author><author><style face="normal" font="default" size="100%">Misganaw, Awoke</style></author><author><style face="normal" font="default" size="100%">Mishra, Santosh</style></author><author><style face="normal" font="default" size="100%">Mohamed Ibrahim, Norlinah</style></author><author><style face="normal" font="default" size="100%">Mohammad, Karzan A</style></author><author><style face="normal" font="default" size="100%">Mokdad, Ali H</style></author><author><style face="normal" font="default" size="100%">Mola, Glen L</style></author><author><style face="normal" font="default" size="100%">Monasta, Lorenzo</style></author><author><style face="normal" font="default" size="100%">Montañez Hernandez, Julio C</style></author><author><style face="normal" font="default" size="100%">Montico, Marcella</style></author><author><style face="normal" font="default" size="100%">Moore, Ami R</style></author><author><style face="normal" font="default" size="100%">Morawska, Lidia</style></author><author><style face="normal" font="default" size="100%">Mori, Rintaro</style></author><author><style face="normal" font="default" size="100%">Moschandreas, Joanna</style></author><author><style face="normal" font="default" size="100%">Moturi, Wilkister N</style></author><author><style face="normal" font="default" size="100%">Mozaffarian, Dariush</style></author><author><style face="normal" font="default" size="100%">Mueller, Ulrich O</style></author><author><style face="normal" font="default" size="100%">Mukaigawara, Mitsuru</style></author><author><style face="normal" font="default" size="100%">Mullany, Erin C</style></author><author><style face="normal" font="default" size="100%">Murthy, Kinnari S</style></author><author><style face="normal" font="default" size="100%">Naghavi, Mohsen</style></author><author><style face="normal" font="default" size="100%">Nahas, Ziad</style></author><author><style face="normal" font="default" size="100%">Naheed, Aliya</style></author><author><style face="normal" font="default" size="100%">Naidoo, Kovin S</style></author><author><style face="normal" font="default" size="100%">Naldi, Luigi</style></author><author><style face="normal" font="default" size="100%">Nand, Devina</style></author><author><style face="normal" font="default" size="100%">Nangia, Vinay</style></author><author><style face="normal" font="default" size="100%">Narayan, K M Venkat</style></author><author><style face="normal" font="default" size="100%">Nash, Denis</style></author><author><style face="normal" font="default" size="100%">Neal, Bruce</style></author><author><style face="normal" font="default" size="100%">Nejjari, Chakib</style></author><author><style face="normal" font="default" size="100%">Neupane, Sudan P</style></author><author><style face="normal" font="default" size="100%">Newton, Charles R</style></author><author><style face="normal" font="default" size="100%">Ngalesoni, Frida N</style></author><author><style face="normal" font="default" size="100%">Ngirabega, Jean de Dieu</style></author><author><style face="normal" font="default" size="100%">Nguyen, Grant</style></author><author><style face="normal" font="default" size="100%">Nguyen, Nhung T</style></author><author><style face="normal" font="default" size="100%">Nieuwenhuijsen, Mark J</style></author><author><style face="normal" font="default" size="100%">Nisar, Muhammad I</style></author><author><style face="normal" font="default" size="100%">Nogueira, José R</style></author><author><style face="normal" font="default" size="100%">Nolla, Joan M</style></author><author><style face="normal" font="default" size="100%">Nolte, Sandra</style></author><author><style face="normal" font="default" size="100%">Norheim, Ole F</style></author><author><style face="normal" font="default" size="100%">Norman, Rosana E</style></author><author><style face="normal" font="default" size="100%">Norrving, Bo</style></author><author><style face="normal" font="default" size="100%">Nyakarahuka, Luke</style></author><author><style face="normal" font="default" size="100%">Oh, In-Hwan</style></author><author><style face="normal" font="default" size="100%">Ohkubo, Takayoshi</style></author><author><style face="normal" font="default" size="100%">Olusanya, Bolajoko O</style></author><author><style face="normal" font="default" size="100%">Omer, Saad B</style></author><author><style face="normal" font="default" size="100%">Opio, John Nelson</style></author><author><style face="normal" font="default" size="100%">Orozco, Ricardo</style></author><author><style face="normal" font="default" size="100%">Pagcatipunan, Rodolfo S</style></author><author><style face="normal" font="default" size="100%">Pain, Amanda W</style></author><author><style face="normal" font="default" size="100%">Pandian, Jeyaraj D</style></author><author><style face="normal" font="default" size="100%">Panelo, Carlo Irwin A</style></author><author><style face="normal" font="default" size="100%">Papachristou, Christina</style></author><author><style face="normal" font="default" size="100%">Park, Eun-Kee</style></author><author><style face="normal" font="default" size="100%">Parry, Charles D</style></author><author><style face="normal" font="default" size="100%">Paternina Caicedo, Angel J</style></author><author><style face="normal" font="default" size="100%">Patten, Scott B</style></author><author><style face="normal" font="default" size="100%">Paul, Vinod K</style></author><author><style face="normal" font="default" size="100%">Pavlin, Boris I</style></author><author><style face="normal" font="default" size="100%">Pearce, Neil</style></author><author><style face="normal" font="default" size="100%">Pedraza, Lilia S</style></author><author><style face="normal" font="default" size="100%">Pedroza, Andrea</style></author><author><style face="normal" font="default" size="100%">Pejin Stokic, Ljiljana</style></author><author><style face="normal" font="default" size="100%">Pekericli, Ayfer</style></author><author><style face="normal" font="default" size="100%">Pereira, David M</style></author><author><style face="normal" font="default" size="100%">Perez-Padilla, Rogelio</style></author><author><style face="normal" font="default" size="100%">Perez-Ruiz, Fernando</style></author><author><style face="normal" font="default" size="100%">Perico, Norberto</style></author><author><style face="normal" font="default" size="100%">Perry, Samuel A L</style></author><author><style face="normal" font="default" size="100%">Pervaiz, Aslam</style></author><author><style face="normal" font="default" size="100%">Pesudovs, Konrad</style></author><author><style face="normal" font="default" size="100%">Peterson, Carrie B</style></author><author><style face="normal" font="default" size="100%">Petzold, Max</style></author><author><style face="normal" font="default" size="100%">Phillips, Michael R</style></author><author><style face="normal" font="default" size="100%">Phua, Hwee Pin</style></author><author><style face="normal" font="default" size="100%">Plass, Dietrich</style></author><author><style face="normal" font="default" size="100%">Poenaru, Dan</style></author><author><style face="normal" font="default" size="100%">Polanczyk, Guilherme V</style></author><author><style face="normal" font="default" size="100%">Polinder, Suzanne</style></author><author><style face="normal" font="default" size="100%">Pond, Constance D</style></author><author><style face="normal" font="default" size="100%">Pope, C Arden</style></author><author><style face="normal" font="default" size="100%">Pope, Daniel</style></author><author><style face="normal" font="default" size="100%">Popova, Svetlana</style></author><author><style face="normal" font="default" size="100%">Pourmalek, Farshad</style></author><author><style face="normal" font="default" size="100%">Powles, John</style></author><author><style face="normal" font="default" size="100%">Prabhakaran, Dorairaj</style></author><author><style face="normal" font="default" size="100%">Prasad, Noela M</style></author><author><style face="normal" font="default" size="100%">Qato, Dima M</style></author><author><style face="normal" font="default" size="100%">Quezada, Amado D</style></author><author><style face="normal" font="default" size="100%">Quistberg, D Alex A</style></author><author><style face="normal" font="default" size="100%">Racapé, Lionel</style></author><author><style face="normal" font="default" size="100%">Rafay, Anwar</style></author><author><style face="normal" font="default" size="100%">Rahimi, Kazem</style></author><author><style face="normal" font="default" size="100%">Rahimi-Movaghar, Vafa</style></author><author><style face="normal" font="default" size="100%">Rahman, Sajjad Ur</style></author><author><style face="normal" font="default" size="100%">Raju, Murugesan</style></author><author><style face="normal" font="default" size="100%">Rakovac, Ivo</style></author><author><style face="normal" font="default" size="100%">Rana, Saleem M</style></author><author><style face="normal" font="default" size="100%">Rao, Mayuree</style></author><author><style face="normal" font="default" size="100%">Razavi, Homie</style></author><author><style face="normal" font="default" size="100%">Reddy, K Srinath</style></author><author><style face="normal" font="default" size="100%">Refaat, Amany H</style></author><author><style face="normal" font="default" size="100%">Rehm, Jürgen</style></author><author><style face="normal" font="default" size="100%">Remuzzi, Giuseppe</style></author><author><style face="normal" font="default" size="100%">Ribeiro, Antonio L</style></author><author><style face="normal" font="default" size="100%">Riccio, Patricia M</style></author><author><style face="normal" font="default" size="100%">Richardson, Lee</style></author><author><style face="normal" font="default" size="100%">Riederer, Anne</style></author><author><style face="normal" font="default" size="100%">Robinson, Margaret</style></author><author><style face="normal" font="default" size="100%">Roca, Anna</style></author><author><style face="normal" font="default" size="100%">Rodriguez, Alina</style></author><author><style face="normal" font="default" size="100%">Rojas-Rueda, David</style></author><author><style face="normal" font="default" size="100%">Romieu, Isabelle</style></author><author><style face="normal" font="default" size="100%">Ronfani, Luca</style></author><author><style face="normal" font="default" size="100%">Room, Robin</style></author><author><style face="normal" font="default" size="100%">Roy, Nobhojit</style></author><author><style face="normal" font="default" size="100%">Ruhago, George M</style></author><author><style face="normal" font="default" size="100%">Rushton, Lesley</style></author><author><style face="normal" font="default" size="100%">Sabin, Nsanzimana</style></author><author><style face="normal" font="default" size="100%">Sacco, Ralph L</style></author><author><style face="normal" font="default" size="100%">Saha, Sukanta</style></author><author><style face="normal" font="default" size="100%">Sahathevan, Ramesh</style></author><author><style face="normal" font="default" size="100%">Sahraian, Mohammad Ali</style></author><author><style face="normal" font="default" size="100%">Salomon, Joshua A</style></author><author><style face="normal" font="default" size="100%">Salvo, Deborah</style></author><author><style face="normal" font="default" size="100%">Sampson, Uchechukwu K</style></author><author><style face="normal" font="default" size="100%">Sanabria, Juan R</style></author><author><style face="normal" font="default" size="100%">Sanchez, Luz Maria</style></author><author><style face="normal" font="default" size="100%">Sánchez-Pimienta, Tania G</style></author><author><style face="normal" font="default" size="100%">Sanchez-Riera, Lidia</style></author><author><style face="normal" font="default" size="100%">Sandar, Logan</style></author><author><style face="normal" font="default" size="100%">Santos, Itamar S</style></author><author><style face="normal" font="default" size="100%">Sapkota, Amir</style></author><author><style face="normal" font="default" size="100%">Satpathy, Maheswar</style></author><author><style face="normal" font="default" size="100%">Saunders, James E</style></author><author><style face="normal" font="default" size="100%">Sawhney, Monika</style></author><author><style face="normal" font="default" size="100%">Saylan, Mete I</style></author><author><style face="normal" font="default" size="100%">Scarborough, Peter</style></author><author><style face="normal" font="default" size="100%">Schmidt, Jürgen C</style></author><author><style face="normal" font="default" size="100%">Schneider, Ione J C</style></author><author><style face="normal" font="default" size="100%">Schöttker, Ben</style></author><author><style face="normal" font="default" size="100%">Schwebel, David C</style></author><author><style face="normal" font="default" size="100%">Scott, James G</style></author><author><style face="normal" font="default" size="100%">Seedat, Soraya</style></author><author><style face="normal" font="default" size="100%">Sepanlou, Sadaf G</style></author><author><style face="normal" font="default" size="100%">Serdar, Berrin</style></author><author><style face="normal" font="default" size="100%">Servan-Mori, Edson E</style></author><author><style face="normal" font="default" size="100%">Shaddick, Gavin</style></author><author><style face="normal" font="default" size="100%">Shahraz, Saeid</style></author><author><style face="normal" font="default" size="100%">Levy, Teresa Shamah</style></author><author><style face="normal" font="default" size="100%">Shangguan, Siyi</style></author><author><style face="normal" font="default" size="100%">She, Jun</style></author><author><style face="normal" font="default" size="100%">Sheikhbahaei, Sara</style></author><author><style face="normal" font="default" size="100%">Shibuya, Kenji</style></author><author><style face="normal" font="default" size="100%">Shin, Hwashin H</style></author><author><style face="normal" font="default" size="100%">Shinohara, Yukito</style></author><author><style face="normal" font="default" size="100%">Shiri, Rahman</style></author><author><style face="normal" font="default" size="100%">Shishani, Kawkab</style></author><author><style face="normal" font="default" size="100%">Shiue, Ivy</style></author><author><style face="normal" font="default" size="100%">Sigfusdottir, Inga D</style></author><author><style face="normal" font="default" size="100%">Silberberg, Donald H</style></author><author><style face="normal" font="default" size="100%">Simard, Edgar P</style></author><author><style face="normal" font="default" size="100%">Sindi, Shireen</style></author><author><style face="normal" font="default" size="100%">Singh, Abhishek</style></author><author><style face="normal" font="default" size="100%">Singh, Gitanjali M</style></author><author><style face="normal" font="default" size="100%">Singh, Jasvinder A</style></author><author><style face="normal" font="default" size="100%">Skirbekk, Vegard</style></author><author><style face="normal" font="default" size="100%">Sliwa, Karen</style></author><author><style face="normal" font="default" size="100%">Soljak, Michael</style></author><author><style face="normal" font="default" size="100%">Soneji, Samir</style></author><author><style face="normal" font="default" size="100%">Søreide, Kjetil</style></author><author><style face="normal" font="default" size="100%">Soshnikov, Sergey</style></author><author><style face="normal" font="default" size="100%">Sposato, Luciano A</style></author><author><style face="normal" font="default" size="100%">Sreeramareddy, Chandrashekhar T</style></author><author><style face="normal" font="default" size="100%">Stapelberg, Nicolas J C</style></author><author><style face="normal" font="default" size="100%">Stathopoulou, Vasiliki</style></author><author><style face="normal" font="default" size="100%">Steckling, Nadine</style></author><author><style face="normal" font="default" size="100%">Stein, Dan J</style></author><author><style face="normal" font="default" size="100%">Stein, Murray B</style></author><author><style face="normal" font="default" size="100%">Stephens, Natalie</style></author><author><style face="normal" font="default" size="100%">Stöckl, Heidi</style></author><author><style face="normal" font="default" size="100%">Straif, Kurt</style></author><author><style face="normal" font="default" size="100%">Stroumpoulis, Konstantinos</style></author><author><style face="normal" font="default" size="100%">Sturua, Lela</style></author><author><style face="normal" font="default" size="100%">Sunguya, Bruno F</style></author><author><style face="normal" font="default" size="100%">Swaminathan, Soumya</style></author><author><style face="normal" font="default" size="100%">Swaroop, Mamta</style></author><author><style face="normal" font="default" size="100%">Sykes, Bryan L</style></author><author><style face="normal" font="default" size="100%">Tabb, Karen M</style></author><author><style face="normal" font="default" size="100%">Takahashi, Ken</style></author><author><style face="normal" font="default" size="100%">Talongwa, Roberto T</style></author><author><style face="normal" font="default" size="100%">Tandon, Nikhil</style></author><author><style face="normal" font="default" size="100%">Tanne, David</style></author><author><style face="normal" font="default" size="100%">Tanner, Marcel</style></author><author><style face="normal" font="default" size="100%">Tavakkoli, Mohammad</style></author><author><style face="normal" font="default" size="100%">Te Ao, Braden J</style></author><author><style face="normal" font="default" size="100%">Teixeira, Carolina M</style></author><author><style face="normal" font="default" size="100%">Téllez Rojo, Martha M</style></author><author><style face="normal" font="default" size="100%">Terkawi, Abdullah S</style></author><author><style face="normal" font="default" size="100%">Texcalac-Sangrador, José Luis</style></author><author><style face="normal" font="default" size="100%">Thackway, Sarah V</style></author><author><style face="normal" font="default" size="100%">Thomson, Blake</style></author><author><style face="normal" font="default" size="100%">Thorne-Lyman, Andrew L</style></author><author><style face="normal" font="default" size="100%">Thrift, Amanda G</style></author><author><style face="normal" font="default" size="100%">Thurston, George D</style></author><author><style face="normal" font="default" size="100%">Tillmann, Taavi</style></author><author><style face="normal" font="default" size="100%">Tobollik, Myriam</style></author><author><style face="normal" font="default" size="100%">Tonelli, Marcello</style></author><author><style face="normal" font="default" size="100%">Topouzis, Fotis</style></author><author><style face="normal" font="default" size="100%">Towbin, Jeffrey A</style></author><author><style face="normal" font="default" size="100%">Toyoshima, Hideaki</style></author><author><style face="normal" font="default" size="100%">Traebert, Jefferson</style></author><author><style face="normal" font="default" size="100%">Tran, Bach X</style></author><author><style face="normal" font="default" size="100%">Trasande, Leonardo</style></author><author><style face="normal" font="default" size="100%">Trillini, Matias</style></author><author><style face="normal" font="default" size="100%">Trujillo, Ulises</style></author><author><style face="normal" font="default" size="100%">Dimbuene, Zacharie Tsala</style></author><author><style face="normal" font="default" size="100%">Tsilimbaris, Miltiadis</style></author><author><style face="normal" font="default" size="100%">Tuzcu, Emin Murat</style></author><author><style face="normal" font="default" size="100%">Uchendu, Uche S</style></author><author><style face="normal" font="default" size="100%">Ukwaja, Kingsley N</style></author><author><style face="normal" font="default" size="100%">Uzun, Selen B</style></author><author><style face="normal" font="default" size="100%">van de Vijver, Steven</style></author><author><style face="normal" font="default" size="100%">Van Dingenen, Rita</style></author><author><style face="normal" font="default" size="100%">van Gool, Coen H</style></author><author><style face="normal" font="default" size="100%">van Os, Jim</style></author><author><style face="normal" font="default" size="100%">Varakin, Yuri Y</style></author><author><style face="normal" font="default" size="100%">Vasankari, Tommi J</style></author><author><style face="normal" font="default" size="100%">Vasconcelos, Ana Maria N</style></author><author><style face="normal" font="default" size="100%">Vavilala, Monica S</style></author><author><style face="normal" font="default" size="100%">Veerman, Lennert J</style></author><author><style face="normal" font="default" size="100%">Velasquez-Melendez, Gustavo</style></author><author><style face="normal" font="default" size="100%">Venketasubramanian, N</style></author><author><style face="normal" font="default" size="100%">Vijayakumar, Lakshmi</style></author><author><style face="normal" font="default" size="100%">Villalpando, Salvador</style></author><author><style face="normal" font="default" size="100%">Violante, Francesco S</style></author><author><style face="normal" font="default" size="100%">Vlassov, Vasiliy Victorovich</style></author><author><style face="normal" font="default" size="100%">Vollset, Stein Emil</style></author><author><style face="normal" font="default" size="100%">Wagner, Gregory R</style></author><author><style face="normal" font="default" size="100%">Waller, Stephen G</style></author><author><style face="normal" font="default" size="100%">Wallin, Mitchell T</style></author><author><style face="normal" font="default" size="100%">Wan, Xia</style></author><author><style face="normal" font="default" size="100%">Wang, Haidong</style></author><author><style face="normal" font="default" size="100%">Wang, JianLi</style></author><author><style face="normal" font="default" size="100%">Wang, Linhong</style></author><author><style face="normal" font="default" size="100%">Wang, Wenzhi</style></author><author><style face="normal" font="default" size="100%">Wang, Yanping</style></author><author><style face="normal" font="default" size="100%">Warouw, Tati S</style></author><author><style face="normal" font="default" size="100%">Watts, Charlotte H</style></author><author><style face="normal" font="default" size="100%">Weichenthal, Scott</style></author><author><style face="normal" font="default" size="100%">Weiderpass, Elisabete</style></author><author><style face="normal" font="default" size="100%">Weintraub, Robert G</style></author><author><style face="normal" font="default" size="100%">Werdecker, Andrea</style></author><author><style face="normal" font="default" size="100%">Wessells, K Ryan</style></author><author><style face="normal" font="default" size="100%">Westerman, Ronny</style></author><author><style face="normal" font="default" size="100%">Whiteford, Harvey A</style></author><author><style face="normal" font="default" size="100%">Wilkinson, James D</style></author><author><style face="normal" font="default" size="100%">Williams, Hywel C</style></author><author><style face="normal" font="default" size="100%">Williams, Thomas N</style></author><author><style face="normal" font="default" size="100%">Woldeyohannes, Solomon M</style></author><author><style face="normal" font="default" size="100%">Wolfe, Charles D A</style></author><author><style face="normal" font="default" size="100%">Wong, John Q</style></author><author><style face="normal" font="default" size="100%">Woolf, Anthony D</style></author><author><style face="normal" font="default" size="100%">Wright, Jonathan L</style></author><author><style face="normal" font="default" size="100%">Wurtz, Brittany</style></author><author><style face="normal" font="default" size="100%">Xu, Gelin</style></author><author><style face="normal" font="default" size="100%">Yan, Lijing L</style></author><author><style face="normal" font="default" size="100%">Yang, Gonghuan</style></author><author><style face="normal" font="default" size="100%">Yano, Yuichiro</style></author><author><style face="normal" font="default" size="100%">Ye, Pengpeng</style></author><author><style face="normal" font="default" size="100%">Yenesew, Muluken</style></author><author><style face="normal" font="default" size="100%">Yentür, Gökalp K</style></author><author><style face="normal" font="default" size="100%">Yip, Paul</style></author><author><style face="normal" font="default" size="100%">Yonemoto, Naohiro</style></author><author><style face="normal" font="default" size="100%">Yoon, Seok-Jun</style></author><author><style face="normal" font="default" size="100%">Younis, Mustafa Z</style></author><author><style face="normal" font="default" size="100%">Younoussi, Zourkaleini</style></author><author><style face="normal" font="default" size="100%">Yu, Chuanhua</style></author><author><style face="normal" font="default" size="100%">Zaki, Maysaa E</style></author><author><style face="normal" font="default" size="100%">Zhao, Yong</style></author><author><style face="normal" font="default" size="100%">Zheng, Yingfeng</style></author><author><style face="normal" font="default" size="100%">Zhou, Maigeng</style></author><author><style face="normal" font="default" size="100%">Zhu, Jun</style></author><author><style face="normal" font="default" size="100%">Zhu, Shankuan</style></author><author><style face="normal" font="default" size="100%">Zou, Xiaonong</style></author><author><style face="normal" font="default" size="100%">Zunt, Joseph R</style></author><author><style face="normal" font="default" size="100%">Lopez, Alan D</style></author><author><style face="normal" font="default" size="100%">Vos, Theo</style></author><author><style face="normal" font="default" size="100%">Murray, Christopher J</style></author></authors><translated-authors><author><style face="normal" font="default" size="100%">GBD 2013 Risk Factors Collaborators</style></author></translated-authors></contributors><titles><title><style face="normal" font="default" size="100%">Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013.</style></title><secondary-title><style face="normal" font="default" size="100%">Lancet</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Lancet</style></alt-title></titles><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2015 Dec 5</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">386</style></volume><pages><style face="normal" font="default" size="100%">2287-323</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;b&gt;BACKGROUND: &lt;/b&gt;The Global Burden of Disease, Injuries, and Risk Factor study 2013 (GBD 2013) is the first of a series of annual updates of the GBD. Risk factor quantification, particularly of modifiable risk factors, can help to identify emerging threats to population health and opportunities for prevention. The GBD 2013 provides a timely opportunity to update the comparative risk assessment with new data for exposure, relative risks, and evidence on the appropriate counterfactual risk distribution.&lt;/p&gt;&lt;p&gt;&lt;b&gt;METHODS: &lt;/b&gt;Attributable deaths, years of life lost, years lived with disability, and disability-adjusted life-years (DALYs) have been estimated for 79 risks or clusters of risks using the GBD 2010 methods. Risk-outcome pairs meeting explicit evidence criteria were assessed for 188 countries for the period 1990-2013 by age and sex using three inputs: risk exposure, relative risks, and the theoretical minimum risk exposure level (TMREL). Risks are organised into a hierarchy with blocks of behavioural, environmental and occupational, and metabolic risks at the first level of the hierarchy. The next level in the hierarchy includes nine clusters of related risks and two individual risks, with more detail provided at levels 3 and 4 of the hierarchy. Compared with GBD 2010, six new risk factors have been added: handwashing practices, occupational exposure to trichloroethylene, childhood wasting, childhood stunting, unsafe sex, and low glomerular filtration rate. For most risks, data for exposure were synthesised with a Bayesian meta-regression method, DisMod-MR 2.0, or spatial-temporal Gaussian process regression. Relative risks were based on meta-regressions of published cohort and intervention studies. Attributable burden for clusters of risks and all risks combined took into account evidence on the mediation of some risks such as high body-mass index (BMI) through other risks such as high systolic blood pressure and high cholesterol.&lt;/p&gt;&lt;p&gt;&lt;b&gt;FINDINGS: &lt;/b&gt;All risks combined account for 57·2% (95% uncertainty interval [UI] 55·8-58·5) of deaths and 41·6% (40·1-43·0) of DALYs. Risks quantified account for 87·9% (86·5-89·3) of cardiovascular disease DALYs, ranging to a low of 0% for neonatal disorders and neglected tropical diseases and malaria. In terms of global DALYs in 2013, six risks or clusters of risks each caused more than 5% of DALYs: dietary risks accounting for 11·3 million deaths and 241·4 million DALYs, high systolic blood pressure for 10·4 million deaths and 208·1 million DALYs, child and maternal malnutrition for 1·7 million deaths and 176·9 million DALYs, tobacco smoke for 6·1 million deaths and 143·5 million DALYs, air pollution for 5·5 million deaths and 141·5 million DALYs, and high BMI for 4·4 million deaths and 134·0 million DALYs. Risk factor patterns vary across regions and countries and with time. In sub-Saharan Africa, the leading risk factors are child and maternal malnutrition, unsafe sex, and unsafe water, sanitation, and handwashing. In women, in nearly all countries in the Americas, north Africa, and the Middle East, and in many other high-income countries, high BMI is the leading risk factor, with high systolic blood pressure as the leading risk in most of Central and Eastern Europe and south and east Asia. For men, high systolic blood pressure or tobacco use are the leading risks in nearly all high-income countries, in north Africa and the Middle East, Europe, and Asia. For men and women, unsafe sex is the leading risk in a corridor from Kenya to South Africa.&lt;/p&gt;&lt;p&gt;&lt;b&gt;INTERPRETATION: &lt;/b&gt;Behavioural, environmental and occupational, and metabolic risks can explain half of global mortality and more than one-third of global DALYs providing many opportunities for prevention. Of the larger risks, the attributable burden of high BMI has increased in the past 23 years. In view of the prominence of behavioural risk factors, behavioural and social science research on interventions for these risks should be strengthened. Many prevention and primary care policy options are available now to act on key risks.&lt;/p&gt;&lt;p&gt;&lt;b&gt;FUNDING: &lt;/b&gt;Bill &amp; Melinda Gates Foundation.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">10010</style></issue><custom1><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/26364544?dopt=Abstract</style></custom1></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Murray, Christopher J L</style></author><author><style face="normal" font="default" size="100%">Barber, Ryan M</style></author><author><style face="normal" font="default" size="100%">Foreman, Kyle J</style></author><author><style face="normal" font="default" size="100%">Abbasoglu Ozgoren, Ayse</style></author><author><style face="normal" font="default" size="100%">Abd-Allah, Foad</style></author><author><style face="normal" font="default" size="100%">Abera, Semaw F</style></author><author><style face="normal" font="default" size="100%">Aboyans, Victor</style></author><author><style face="normal" font="default" size="100%">Abraham, Jerry P</style></author><author><style face="normal" font="default" size="100%">Abubakar, Ibrahim</style></author><author><style face="normal" font="default" size="100%">Abu-Raddad, Laith J</style></author><author><style face="normal" font="default" size="100%">Abu-Rmeileh, Niveen M</style></author><author><style face="normal" font="default" size="100%">Achoki, Tom</style></author><author><style face="normal" font="default" size="100%">Ackerman, Ilana N</style></author><author><style face="normal" font="default" size="100%">Ademi, Zanfina</style></author><author><style face="normal" font="default" size="100%">Adou, Arsène K</style></author><author><style face="normal" font="default" size="100%">Adsuar, José C</style></author><author><style face="normal" font="default" size="100%">Afshin, Ashkan</style></author><author><style face="normal" font="default" size="100%">Agardh, Emilie E</style></author><author><style face="normal" font="default" size="100%">Alam, Sayed Saidul</style></author><author><style face="normal" font="default" size="100%">Alasfoor, Deena</style></author><author><style face="normal" font="default" size="100%">Albittar, Mohammed I</style></author><author><style face="normal" font="default" size="100%">Alegretti, Miguel A</style></author><author><style face="normal" font="default" size="100%">Alemu, Zewdie A</style></author><author><style face="normal" font="default" size="100%">Alfonso-Cristancho, Rafael</style></author><author><style face="normal" font="default" size="100%">Alhabib, Samia</style></author><author><style face="normal" font="default" size="100%">Ali, Raghib</style></author><author><style face="normal" font="default" size="100%">Alla, François</style></author><author><style face="normal" font="default" size="100%">Allebeck, Peter</style></author><author><style face="normal" font="default" size="100%">AlMazroa, Mohammad A</style></author><author><style face="normal" font="default" size="100%">Alsharif, Ubai</style></author><author><style face="normal" font="default" size="100%">Alvarez, Elena</style></author><author><style face="normal" font="default" size="100%">Alvis-Guzmán, Nelson</style></author><author><style face="normal" font="default" size="100%">Amare, Azmeraw T</style></author><author><style face="normal" font="default" size="100%">Ameh, Emmanuel A</style></author><author><style face="normal" font="default" size="100%">Amini, Heresh</style></author><author><style face="normal" font="default" size="100%">Ammar, Walid</style></author><author><style face="normal" font="default" size="100%">Anderson, H Ross</style></author><author><style face="normal" font="default" size="100%">Anderson, Benjamin O</style></author><author><style face="normal" font="default" size="100%">Antonio, Carl Abelardo T</style></author><author><style face="normal" font="default" size="100%">Anwari, Palwasha</style></author><author><style face="normal" font="default" size="100%">Arnlöv, Johan</style></author><author><style face="normal" font="default" size="100%">Arsic Arsenijevic, Valentina S</style></author><author><style face="normal" font="default" size="100%">Artaman, Al</style></author><author><style face="normal" font="default" size="100%">Asghar, Rana J</style></author><author><style face="normal" font="default" size="100%">Assadi, Reza</style></author><author><style face="normal" font="default" size="100%">Atkins, Lydia S</style></author><author><style face="normal" font="default" size="100%">Avila, Marco A</style></author><author><style face="normal" font="default" size="100%">Awuah, Baffour</style></author><author><style face="normal" font="default" size="100%">Bachman, Victoria F</style></author><author><style face="normal" font="default" size="100%">Badawi, Alaa</style></author><author><style face="normal" font="default" size="100%">Bahit, Maria C</style></author><author><style face="normal" font="default" size="100%">Balakrishnan, Kalpana</style></author><author><style face="normal" font="default" size="100%">Banerjee, Amitava</style></author><author><style face="normal" font="default" size="100%">Barker-Collo, Suzanne L</style></author><author><style face="normal" font="default" size="100%">Barquera, Simon</style></author><author><style face="normal" font="default" size="100%">Barregard, Lars</style></author><author><style face="normal" font="default" size="100%">Barrero, Lope H</style></author><author><style face="normal" font="default" size="100%">Basu, Arindam</style></author><author><style face="normal" font="default" size="100%">Basu, Sanjay</style></author><author><style face="normal" font="default" size="100%">Basulaiman, Mohammed O</style></author><author><style face="normal" font="default" size="100%">Beardsley, Justin</style></author><author><style face="normal" font="default" size="100%">Bedi, Neeraj</style></author><author><style face="normal" font="default" size="100%">Beghi, Ettore</style></author><author><style face="normal" font="default" size="100%">Bekele, Tolesa</style></author><author><style face="normal" font="default" size="100%">Bell, Michelle L</style></author><author><style face="normal" font="default" size="100%">Benjet, Corina</style></author><author><style face="normal" font="default" size="100%">Bennett, Derrick A</style></author><author><style face="normal" font="default" size="100%">Bensenor, Isabela M</style></author><author><style face="normal" font="default" size="100%">Benzian, Habib</style></author><author><style face="normal" font="default" size="100%">Bernabe, Eduardo</style></author><author><style face="normal" font="default" size="100%">Bertozzi-Villa, Amelia</style></author><author><style face="normal" font="default" size="100%">Beyene, Tariku J</style></author><author><style face="normal" font="default" size="100%">Bhala, Neeraj</style></author><author><style face="normal" font="default" size="100%">Bhalla, Ashish</style></author><author><style face="normal" font="default" size="100%">Bhutta, Zulfiqar A</style></author><author><style face="normal" font="default" size="100%">Bienhoff, Kelly</style></author><author><style face="normal" font="default" size="100%">Bikbov, Boris</style></author><author><style face="normal" font="default" size="100%">Biryukov, Stan</style></author><author><style face="normal" font="default" size="100%">Blore, Jed D</style></author><author><style face="normal" font="default" size="100%">Blosser, Christopher D</style></author><author><style face="normal" font="default" size="100%">Blyth, Fiona M</style></author><author><style face="normal" font="default" size="100%">Bohensky, Megan A</style></author><author><style face="normal" font="default" size="100%">Bolliger, Ian W</style></author><author><style face="normal" font="default" size="100%">Bora Başara, Berrak</style></author><author><style face="normal" font="default" size="100%">Bornstein, Natan M</style></author><author><style face="normal" font="default" size="100%">Bose, Dipan</style></author><author><style face="normal" font="default" size="100%">Boufous, Soufiane</style></author><author><style face="normal" font="default" size="100%">Bourne, Rupert R A</style></author><author><style face="normal" font="default" size="100%">Boyers, Lindsay N</style></author><author><style face="normal" font="default" size="100%">Brainin, Michael</style></author><author><style face="normal" font="default" size="100%">Brayne, Carol E</style></author><author><style face="normal" font="default" size="100%">Brazinova, Alexandra</style></author><author><style face="normal" font="default" size="100%">Breitborde, Nicholas J K</style></author><author><style face="normal" font="default" size="100%">Brenner, Hermann</style></author><author><style face="normal" font="default" size="100%">Briggs, Adam D</style></author><author><style face="normal" font="default" size="100%">Brooks, Peter M</style></author><author><style face="normal" font="default" size="100%">Brown, Jonathan C</style></author><author><style face="normal" font="default" size="100%">Brugha, Traolach S</style></author><author><style face="normal" font="default" size="100%">Buchbinder, Rachelle</style></author><author><style face="normal" font="default" size="100%">Buckle, Geoffrey C</style></author><author><style face="normal" font="default" size="100%">Budke, Christine M</style></author><author><style face="normal" font="default" size="100%">Bulchis, Anne</style></author><author><style face="normal" font="default" size="100%">Bulloch, Andrew G</style></author><author><style face="normal" font="default" size="100%">Campos-Nonato, Ismael R</style></author><author><style face="normal" font="default" size="100%">Carabin, Hélène</style></author><author><style face="normal" font="default" size="100%">Carapetis, Jonathan R</style></author><author><style face="normal" font="default" size="100%">Cárdenas, Rosario</style></author><author><style face="normal" font="default" size="100%">Carpenter, David O</style></author><author><style face="normal" font="default" size="100%">Caso, Valeria</style></author><author><style face="normal" font="default" size="100%">Castañeda-Orjuela, Carlos A</style></author><author><style face="normal" font="default" size="100%">Castro, Ruben E</style></author><author><style face="normal" font="default" size="100%">Catalá-López, Ferrán</style></author><author><style face="normal" font="default" size="100%">Cavalleri, Fiorella</style></author><author><style face="normal" font="default" size="100%">Cavlin, Alanur</style></author><author><style face="normal" font="default" size="100%">Chadha, Vineet K</style></author><author><style face="normal" font="default" size="100%">Chang, Jung-Chen</style></author><author><style face="normal" font="default" size="100%">Charlson, Fiona J</style></author><author><style face="normal" font="default" size="100%">Chen, Honglei</style></author><author><style face="normal" font="default" size="100%">Chen, Wanqing</style></author><author><style face="normal" font="default" size="100%">Chiang, Peggy P</style></author><author><style face="normal" font="default" size="100%">Chimed-Ochir, Odgerel</style></author><author><style face="normal" font="default" size="100%">Chowdhury, Rajiv</style></author><author><style face="normal" font="default" size="100%">Christensen, Hanne</style></author><author><style face="normal" font="default" size="100%">Christophi, Costas A</style></author><author><style face="normal" font="default" size="100%">Cirillo, Massimo</style></author><author><style face="normal" font="default" size="100%">Coates, Matthew M</style></author><author><style face="normal" font="default" size="100%">Coffeng, Luc E</style></author><author><style face="normal" font="default" size="100%">Coggeshall, Megan S</style></author><author><style face="normal" font="default" size="100%">Colistro, Valentina</style></author><author><style face="normal" font="default" size="100%">Colquhoun, Samantha M</style></author><author><style face="normal" font="default" size="100%">Cooke, Graham S</style></author><author><style face="normal" font="default" size="100%">Cooper, Cyrus</style></author><author><style face="normal" font="default" size="100%">Cooper, Leslie T</style></author><author><style face="normal" font="default" size="100%">Coppola, Luis M</style></author><author><style face="normal" font="default" size="100%">Cortinovis, Monica</style></author><author><style face="normal" font="default" size="100%">Criqui, Michael H</style></author><author><style face="normal" font="default" size="100%">Crump, John A</style></author><author><style face="normal" font="default" size="100%">Cuevas-Nasu, Lucia</style></author><author><style face="normal" font="default" size="100%">Danawi, Hadi</style></author><author><style face="normal" font="default" size="100%">Dandona, Lalit</style></author><author><style face="normal" font="default" size="100%">Dandona, Rakhi</style></author><author><style face="normal" font="default" size="100%">Dansereau, Emily</style></author><author><style face="normal" font="default" size="100%">Dargan, Paul I</style></author><author><style face="normal" font="default" size="100%">Davey, Gail</style></author><author><style face="normal" font="default" size="100%">Davis, Adrian</style></author><author><style face="normal" font="default" size="100%">Davitoiu, Dragos V</style></author><author><style face="normal" font="default" size="100%">Dayama, Anand</style></author><author><style face="normal" font="default" size="100%">De Leo, Diego</style></author><author><style face="normal" font="default" size="100%">Degenhardt, Louisa</style></author><author><style face="normal" font="default" size="100%">del Pozo-Cruz, Borja</style></author><author><style face="normal" font="default" size="100%">Dellavalle, Robert P</style></author><author><style face="normal" font="default" size="100%">Deribe, Kebede</style></author><author><style face="normal" font="default" size="100%">Derrett, Sarah</style></author><author><style face="normal" font="default" size="100%">Des Jarlais, Don C</style></author><author><style face="normal" font="default" size="100%">Dessalegn, Muluken</style></author><author><style face="normal" font="default" size="100%">Dharmaratne, Samath D</style></author><author><style face="normal" font="default" size="100%">Dherani, Mukesh K</style></author><author><style face="normal" font="default" size="100%">Diaz-Torné, Cesar</style></author><author><style face="normal" font="default" size="100%">Dicker, Daniel</style></author><author><style face="normal" font="default" size="100%">Ding, Eric L</style></author><author><style face="normal" font="default" size="100%">Dokova, Klara</style></author><author><style face="normal" font="default" size="100%">Dorsey, E Ray</style></author><author><style face="normal" font="default" size="100%">Driscoll, Tim R</style></author><author><style face="normal" font="default" size="100%">Duan, Leilei</style></author><author><style face="normal" font="default" size="100%">Duber, Herbert C</style></author><author><style face="normal" font="default" size="100%">Ebel, Beth E</style></author><author><style face="normal" font="default" size="100%">Edmond, Karen M</style></author><author><style face="normal" font="default" size="100%">Elshrek, Yousef M</style></author><author><style face="normal" font="default" size="100%">Endres, Matthias</style></author><author><style face="normal" font="default" size="100%">Ermakov, Sergey P</style></author><author><style face="normal" font="default" size="100%">Erskine, Holly E</style></author><author><style face="normal" font="default" size="100%">Eshrati, Babak</style></author><author><style face="normal" font="default" size="100%">Esteghamati, Alireza</style></author><author><style face="normal" font="default" size="100%">Estep, Kara</style></author><author><style face="normal" font="default" size="100%">Faraon, Emerito Jose A</style></author><author><style face="normal" font="default" size="100%">Farzadfar, Farshad</style></author><author><style face="normal" font="default" size="100%">Fay, Derek F</style></author><author><style face="normal" font="default" size="100%">Feigin, Valery L</style></author><author><style face="normal" font="default" size="100%">Felson, David T</style></author><author><style face="normal" font="default" size="100%">Fereshtehnejad, Seyed-Mohammad</style></author><author><style face="normal" font="default" size="100%">Fernandes, Jefferson G</style></author><author><style face="normal" font="default" size="100%">Ferrari, Alize J</style></author><author><style face="normal" font="default" size="100%">Fitzmaurice, Christina</style></author><author><style face="normal" font="default" size="100%">Flaxman, Abraham D</style></author><author><style face="normal" font="default" size="100%">Fleming, Thomas D</style></author><author><style face="normal" font="default" size="100%">Foigt, Nataliya</style></author><author><style face="normal" font="default" size="100%">Forouzanfar, Mohammad H</style></author><author><style face="normal" font="default" size="100%">Fowkes, F Gerry R</style></author><author><style face="normal" font="default" size="100%">Paleo, Urbano Fra</style></author><author><style face="normal" font="default" size="100%">Franklin, Richard C</style></author><author><style face="normal" font="default" size="100%">Fürst, Thomas</style></author><author><style face="normal" font="default" size="100%">Gabbe, Belinda</style></author><author><style face="normal" font="default" size="100%">Gaffikin, Lynne</style></author><author><style face="normal" font="default" size="100%">Gankpé, Fortuné G</style></author><author><style face="normal" font="default" size="100%">Geleijnse, Johanna M</style></author><author><style face="normal" font="default" size="100%">Gessner, Bradford D</style></author><author><style face="normal" font="default" size="100%">Gething, Peter</style></author><author><style face="normal" font="default" size="100%">Gibney, Katherine B</style></author><author><style face="normal" font="default" size="100%">Giroud, Maurice</style></author><author><style face="normal" font="default" size="100%">Giussani, Giorgia</style></author><author><style face="normal" font="default" size="100%">Gomez Dantes, Hector</style></author><author><style face="normal" font="default" size="100%">Gona, Philimon</style></author><author><style face="normal" font="default" size="100%">Gonzalez-Medina, Diego</style></author><author><style face="normal" font="default" size="100%">Gosselin, Richard A</style></author><author><style face="normal" font="default" size="100%">Gotay, Carolyn C</style></author><author><style face="normal" font="default" size="100%">Goto, Atsushi</style></author><author><style face="normal" font="default" size="100%">Gouda, Hebe N</style></author><author><style face="normal" font="default" size="100%">Graetz, Nicholas</style></author><author><style face="normal" font="default" size="100%">Gugnani, Harish C</style></author><author><style face="normal" font="default" size="100%">Gupta, Rahul</style></author><author><style face="normal" font="default" size="100%">Gupta, Rajeev</style></author><author><style face="normal" font="default" size="100%">Gutiérrez, Reyna A</style></author><author><style face="normal" font="default" size="100%">Haagsma, Juanita</style></author><author><style face="normal" font="default" size="100%">Hafezi-Nejad, Nima</style></author><author><style face="normal" font="default" size="100%">Hagan, Holly</style></author><author><style face="normal" font="default" size="100%">Halasa, Yara A</style></author><author><style face="normal" font="default" size="100%">Hamadeh, Randah R</style></author><author><style face="normal" font="default" size="100%">Hamavid, Hannah</style></author><author><style face="normal" font="default" size="100%">Hammami, Mouhanad</style></author><author><style face="normal" font="default" size="100%">Hancock, Jamie</style></author><author><style face="normal" font="default" size="100%">Hankey, Graeme J</style></author><author><style face="normal" font="default" size="100%">Hansen, Gillian M</style></author><author><style face="normal" font="default" size="100%">Hao, Yuantao</style></author><author><style face="normal" font="default" size="100%">Harb, Hilda L</style></author><author><style face="normal" font="default" size="100%">Haro, Josep Maria</style></author><author><style face="normal" font="default" size="100%">Havmoeller, Rasmus</style></author><author><style face="normal" font="default" size="100%">Hay, Simon I</style></author><author><style face="normal" font="default" size="100%">Hay, Roderick J</style></author><author><style face="normal" font="default" size="100%">Heredia-Pi, Ileana B</style></author><author><style face="normal" font="default" size="100%">Heuton, Kyle R</style></author><author><style face="normal" font="default" size="100%">Heydarpour, Pouria</style></author><author><style face="normal" font="default" size="100%">Higashi, Hideki</style></author><author><style face="normal" font="default" size="100%">Hijar, Martha</style></author><author><style face="normal" font="default" size="100%">Hoek, Hans W</style></author><author><style face="normal" font="default" size="100%">Hoffman, Howard J</style></author><author><style face="normal" font="default" size="100%">Hosgood, H Dean</style></author><author><style face="normal" font="default" size="100%">Hossain, Mazeda</style></author><author><style face="normal" font="default" size="100%">Hotez, Peter J</style></author><author><style face="normal" font="default" size="100%">Hoy, Damian G</style></author><author><style face="normal" font="default" size="100%">Hsairi, Mohamed</style></author><author><style face="normal" font="default" size="100%">Hu, Guoqing</style></author><author><style face="normal" font="default" size="100%">Huang, Cheng</style></author><author><style face="normal" font="default" size="100%">Huang, John J</style></author><author><style face="normal" font="default" size="100%">Husseini, Abdullatif</style></author><author><style face="normal" font="default" size="100%">Huynh, Chantal</style></author><author><style face="normal" font="default" size="100%">Iannarone, Marissa L</style></author><author><style face="normal" font="default" size="100%">Iburg, Kim M</style></author><author><style face="normal" font="default" size="100%">Innos, Kaire</style></author><author><style face="normal" font="default" size="100%">Inoue, Manami</style></author><author><style face="normal" font="default" size="100%">Islami, Farhad</style></author><author><style face="normal" font="default" size="100%">Jacobsen, Kathryn H</style></author><author><style face="normal" font="default" size="100%">Jarvis, Deborah L</style></author><author><style face="normal" font="default" size="100%">Jassal, Simerjot K</style></author><author><style face="normal" font="default" size="100%">Jee, Sun Ha</style></author><author><style face="normal" font="default" size="100%">Jeemon, Panniyammakal</style></author><author><style face="normal" font="default" size="100%">Jensen, Paul N</style></author><author><style face="normal" font="default" size="100%">Jha, Vivekanand</style></author><author><style face="normal" font="default" size="100%">Jiang, Guohong</style></author><author><style face="normal" font="default" size="100%">Jiang, Ying</style></author><author><style face="normal" font="default" size="100%">Jonas, Jost B</style></author><author><style face="normal" font="default" size="100%">Juel, Knud</style></author><author><style face="normal" font="default" size="100%">Kan, Haidong</style></author><author><style face="normal" font="default" size="100%">Karch, André</style></author><author><style face="normal" font="default" size="100%">Karema, Corine K</style></author><author><style face="normal" font="default" size="100%">Karimkhani, Chante</style></author><author><style face="normal" font="default" size="100%">Karthikeyan, Ganesan</style></author><author><style face="normal" font="default" size="100%">Kassebaum, Nicholas J</style></author><author><style face="normal" font="default" size="100%">Kaul, Anil</style></author><author><style face="normal" font="default" size="100%">Kawakami, Norito</style></author><author><style face="normal" font="default" size="100%">Kazanjan, Konstantin</style></author><author><style face="normal" font="default" size="100%">Kemp, Andrew H</style></author><author><style face="normal" font="default" size="100%">Kengne, Andre P</style></author><author><style face="normal" font="default" size="100%">Keren, Andre</style></author><author><style face="normal" font="default" size="100%">Khader, Yousef S</style></author><author><style face="normal" font="default" size="100%">Khalifa, Shams Eldin A</style></author><author><style face="normal" font="default" size="100%">Khan, Ejaz A</style></author><author><style face="normal" font="default" size="100%">Khan, Gulfaraz</style></author><author><style face="normal" font="default" size="100%">Khang, Young-Ho</style></author><author><style face="normal" font="default" size="100%">Kieling, Christian</style></author><author><style face="normal" font="default" size="100%">Kim, Daniel</style></author><author><style face="normal" font="default" size="100%">Kim, Sungroul</style></author><author><style face="normal" font="default" size="100%">Kim, Yunjin</style></author><author><style face="normal" font="default" size="100%">Kinfu, Yohannes</style></author><author><style face="normal" font="default" size="100%">Kinge, Jonas M</style></author><author><style face="normal" font="default" size="100%">Kivipelto, Miia</style></author><author><style face="normal" font="default" size="100%">Knibbs, Luke D</style></author><author><style face="normal" font="default" size="100%">Knudsen, Ann Kristin</style></author><author><style face="normal" font="default" size="100%">Kokubo, Yoshihiro</style></author><author><style face="normal" font="default" size="100%">Kosen, Soewarta</style></author><author><style face="normal" font="default" size="100%">Krishnaswami, Sanjay</style></author><author><style face="normal" font="default" size="100%">Kuate Defo, Barthelemy</style></author><author><style face="normal" font="default" size="100%">Kucuk Bicer, Burcu</style></author><author><style face="normal" font="default" size="100%">Kuipers, Ernst J</style></author><author><style face="normal" font="default" size="100%">Kulkarni, Chanda</style></author><author><style face="normal" font="default" size="100%">Kulkarni, Veena S</style></author><author><style face="normal" font="default" size="100%">Kumar, G Anil</style></author><author><style face="normal" font="default" size="100%">Kyu, Hmwe H</style></author><author><style face="normal" font="default" size="100%">Lai, Taavi</style></author><author><style face="normal" font="default" size="100%">Lalloo, Ratilal</style></author><author><style face="normal" font="default" size="100%">Lallukka, Tea</style></author><author><style face="normal" font="default" size="100%">Lam, Hilton</style></author><author><style face="normal" font="default" size="100%">Lan, Qing</style></author><author><style face="normal" font="default" size="100%">Lansingh, Van C</style></author><author><style face="normal" font="default" size="100%">Larsson, Anders</style></author><author><style face="normal" font="default" size="100%">Lawrynowicz, Alicia E B</style></author><author><style face="normal" font="default" size="100%">Leasher, Janet L</style></author><author><style face="normal" font="default" size="100%">Leigh, James</style></author><author><style face="normal" font="default" size="100%">Leung, Ricky</style></author><author><style face="normal" font="default" size="100%">Levitz, Carly E</style></author><author><style face="normal" font="default" size="100%">Li, Bin</style></author><author><style face="normal" font="default" size="100%">Li, Yichong</style></author><author><style face="normal" font="default" size="100%">Li, Yongmei</style></author><author><style face="normal" font="default" size="100%">Lim, Stephen S</style></author><author><style face="normal" font="default" size="100%">Lind, Maggie</style></author><author><style face="normal" font="default" size="100%">Lipshultz, Steven E</style></author><author><style face="normal" font="default" size="100%">Liu, Shiwei</style></author><author><style face="normal" font="default" size="100%">Liu, Yang</style></author><author><style face="normal" font="default" size="100%">Lloyd, Belinda K</style></author><author><style face="normal" font="default" size="100%">Lofgren, Katherine T</style></author><author><style face="normal" font="default" size="100%">Logroscino, Giancarlo</style></author><author><style face="normal" font="default" size="100%">Looker, Katharine J</style></author><author><style face="normal" font="default" size="100%">Lortet-Tieulent, Joannie</style></author><author><style face="normal" font="default" size="100%">Lotufo, Paulo A</style></author><author><style face="normal" font="default" size="100%">Lozano, Rafael</style></author><author><style face="normal" font="default" size="100%">Lucas, Robyn M</style></author><author><style face="normal" font="default" size="100%">Lunevicius, Raimundas</style></author><author><style face="normal" font="default" size="100%">Lyons, Ronan A</style></author><author><style face="normal" font="default" size="100%">Ma, Stefan</style></author><author><style face="normal" font="default" size="100%">MacIntyre, Michael F</style></author><author><style face="normal" font="default" size="100%">Mackay, Mark T</style></author><author><style face="normal" font="default" size="100%">Majdan, Marek</style></author><author><style face="normal" font="default" size="100%">Malekzadeh, Reza</style></author><author><style face="normal" font="default" size="100%">Marcenes, Wagner</style></author><author><style face="normal" font="default" size="100%">Margolis, David J</style></author><author><style face="normal" font="default" size="100%">Margono, Christopher</style></author><author><style face="normal" font="default" size="100%">Marzan, Melvin B</style></author><author><style face="normal" font="default" size="100%">Masci, Joseph R</style></author><author><style face="normal" font="default" size="100%">Mashal, Mohammad T</style></author><author><style face="normal" font="default" size="100%">Matzopoulos, Richard</style></author><author><style face="normal" font="default" size="100%">Mayosi, Bongani M</style></author><author><style face="normal" font="default" size="100%">Mazorodze, Tasara T</style></author><author><style face="normal" font="default" size="100%">Mcgill, Neil W</style></author><author><style face="normal" font="default" size="100%">McGrath, John J</style></author><author><style face="normal" font="default" size="100%">McKee, Martin</style></author><author><style face="normal" font="default" size="100%">McLain, Abigail</style></author><author><style face="normal" font="default" size="100%">Meaney, Peter A</style></author><author><style face="normal" font="default" size="100%">Medina, Catalina</style></author><author><style face="normal" font="default" size="100%">Mehndiratta, Man Mohan</style></author><author><style face="normal" font="default" size="100%">Mekonnen, Wubegzier</style></author><author><style face="normal" font="default" size="100%">Melaku, Yohannes A</style></author><author><style face="normal" font="default" size="100%">Meltzer, Michele</style></author><author><style face="normal" font="default" size="100%">Memish, Ziad A</style></author><author><style face="normal" font="default" size="100%">Mensah, George A</style></author><author><style face="normal" font="default" size="100%">Meretoja, Atte</style></author><author><style face="normal" font="default" size="100%">Mhimbira, Francis A</style></author><author><style face="normal" font="default" size="100%">Micha, Renata</style></author><author><style face="normal" font="default" size="100%">Miller, Ted R</style></author><author><style face="normal" font="default" size="100%">Mills, Edward J</style></author><author><style face="normal" font="default" size="100%">Mitchell, Philip B</style></author><author><style face="normal" font="default" size="100%">Mock, Charles N</style></author><author><style face="normal" font="default" size="100%">Mohamed Ibrahim, Norlinah</style></author><author><style face="normal" font="default" size="100%">Mohammad, Karzan A</style></author><author><style face="normal" font="default" size="100%">Mokdad, Ali H</style></author><author><style face="normal" font="default" size="100%">Mola, Glen L D</style></author><author><style face="normal" font="default" size="100%">Monasta, Lorenzo</style></author><author><style face="normal" font="default" size="100%">Montañez Hernandez, Julio C</style></author><author><style face="normal" font="default" size="100%">Montico, Marcella</style></author><author><style face="normal" font="default" size="100%">Montine, Thomas J</style></author><author><style face="normal" font="default" size="100%">Mooney, Meghan D</style></author><author><style face="normal" font="default" size="100%">Moore, Ami R</style></author><author><style face="normal" font="default" size="100%">Moradi-Lakeh, Maziar</style></author><author><style face="normal" font="default" size="100%">Moran, Andrew E</style></author><author><style face="normal" font="default" size="100%">Mori, Rintaro</style></author><author><style face="normal" font="default" size="100%">Moschandreas, Joanna</style></author><author><style face="normal" font="default" size="100%">Moturi, Wilkister N</style></author><author><style face="normal" font="default" size="100%">Moyer, Madeline L</style></author><author><style face="normal" font="default" size="100%">Mozaffarian, Dariush</style></author><author><style face="normal" font="default" size="100%">Msemburi, William T</style></author><author><style face="normal" font="default" size="100%">Mueller, Ulrich O</style></author><author><style face="normal" font="default" size="100%">Mukaigawara, Mitsuru</style></author><author><style face="normal" font="default" size="100%">Mullany, Erin C</style></author><author><style face="normal" font="default" size="100%">Murdoch, Michele E</style></author><author><style face="normal" font="default" size="100%">Murray, Joseph</style></author><author><style face="normal" font="default" size="100%">Murthy, Kinnari S</style></author><author><style face="normal" font="default" size="100%">Naghavi, Mohsen</style></author><author><style face="normal" font="default" size="100%">Naheed, Aliya</style></author><author><style face="normal" font="default" size="100%">Naidoo, Kovin S</style></author><author><style face="normal" font="default" size="100%">Naldi, Luigi</style></author><author><style face="normal" font="default" size="100%">Nand, Devina</style></author><author><style face="normal" font="default" size="100%">Nangia, Vinay</style></author><author><style face="normal" font="default" size="100%">Narayan, K M Venkat</style></author><author><style face="normal" font="default" size="100%">Nejjari, Chakib</style></author><author><style face="normal" font="default" size="100%">Neupane, Sudan P</style></author><author><style face="normal" font="default" size="100%">Newton, Charles R</style></author><author><style face="normal" font="default" size="100%">Ng, Marie</style></author><author><style face="normal" font="default" size="100%">Ngalesoni, Frida N</style></author><author><style face="normal" font="default" size="100%">Nguyen, Grant</style></author><author><style face="normal" font="default" size="100%">Nisar, Muhammad I</style></author><author><style face="normal" font="default" size="100%">Nolte, Sandra</style></author><author><style face="normal" font="default" size="100%">Norheim, Ole F</style></author><author><style face="normal" font="default" size="100%">Norman, Rosana E</style></author><author><style face="normal" font="default" size="100%">Norrving, Bo</style></author><author><style face="normal" font="default" size="100%">Nyakarahuka, Luke</style></author><author><style face="normal" font="default" size="100%">Oh, In-Hwan</style></author><author><style face="normal" font="default" size="100%">Ohkubo, Takayoshi</style></author><author><style face="normal" font="default" size="100%">Ohno, Summer L</style></author><author><style face="normal" font="default" size="100%">Olusanya, Bolajoko O</style></author><author><style face="normal" font="default" size="100%">Opio, John Nelson</style></author><author><style face="normal" font="default" size="100%">Ortblad, Katrina</style></author><author><style face="normal" font="default" size="100%">Ortiz, Alberto</style></author><author><style face="normal" font="default" size="100%">Pain, Amanda W</style></author><author><style face="normal" font="default" size="100%">Pandian, Jeyaraj D</style></author><author><style face="normal" font="default" size="100%">Panelo, Carlo Irwin A</style></author><author><style face="normal" font="default" size="100%">Papachristou, Christina</style></author><author><style face="normal" font="default" size="100%">Park, Eun-Kee</style></author><author><style face="normal" font="default" size="100%">Park, Jae-Hyun</style></author><author><style face="normal" font="default" size="100%">Patten, Scott B</style></author><author><style face="normal" font="default" size="100%">Patton, George C</style></author><author><style face="normal" font="default" size="100%">Paul, Vinod K</style></author><author><style face="normal" font="default" size="100%">Pavlin, Boris I</style></author><author><style face="normal" font="default" size="100%">Pearce, Neil</style></author><author><style face="normal" font="default" size="100%">Pereira, David M</style></author><author><style face="normal" font="default" size="100%">Perez-Padilla, Rogelio</style></author><author><style face="normal" font="default" size="100%">Perez-Ruiz, Fernando</style></author><author><style face="normal" font="default" size="100%">Perico, Norberto</style></author><author><style face="normal" font="default" size="100%">Pervaiz, Aslam</style></author><author><style face="normal" font="default" size="100%">Pesudovs, Konrad</style></author><author><style face="normal" font="default" size="100%">Peterson, Carrie B</style></author><author><style face="normal" font="default" size="100%">Petzold, Max</style></author><author><style face="normal" font="default" size="100%">Phillips, Michael R</style></author><author><style face="normal" font="default" size="100%">Phillips, Bryan K</style></author><author><style face="normal" font="default" size="100%">Phillips, David E</style></author><author><style face="normal" font="default" size="100%">Piel, Frédéric B</style></author><author><style face="normal" font="default" size="100%">Plass, Dietrich</style></author><author><style face="normal" font="default" size="100%">Poenaru, Dan</style></author><author><style face="normal" font="default" size="100%">Polinder, Suzanne</style></author><author><style face="normal" font="default" size="100%">Pope, Daniel</style></author><author><style face="normal" font="default" size="100%">Popova, Svetlana</style></author><author><style face="normal" font="default" size="100%">Poulton, Richie G</style></author><author><style face="normal" font="default" size="100%">Pourmalek, Farshad</style></author><author><style face="normal" font="default" size="100%">Prabhakaran, Dorairaj</style></author><author><style face="normal" font="default" size="100%">Prasad, Noela M</style></author><author><style face="normal" font="default" size="100%">Pullan, Rachel L</style></author><author><style face="normal" font="default" size="100%">Qato, Dima M</style></author><author><style face="normal" font="default" size="100%">Quistberg, D Alex</style></author><author><style face="normal" font="default" size="100%">Rafay, Anwar</style></author><author><style face="normal" font="default" size="100%">Rahimi, Kazem</style></author><author><style face="normal" font="default" size="100%">Rahman, Sajjad U</style></author><author><style face="normal" font="default" size="100%">Raju, Murugesan</style></author><author><style face="normal" font="default" size="100%">Rana, Saleem M</style></author><author><style face="normal" font="default" size="100%">Razavi, Homie</style></author><author><style face="normal" font="default" size="100%">Reddy, K Srinath</style></author><author><style face="normal" font="default" size="100%">Refaat, Amany</style></author><author><style face="normal" font="default" size="100%">Remuzzi, Giuseppe</style></author><author><style face="normal" font="default" size="100%">Resnikoff, Serge</style></author><author><style face="normal" font="default" size="100%">Ribeiro, Antonio L</style></author><author><style face="normal" font="default" size="100%">Richardson, Lee</style></author><author><style face="normal" font="default" size="100%">Richardus, Jan Hendrik</style></author><author><style face="normal" font="default" size="100%">Roberts, D Allen</style></author><author><style face="normal" font="default" size="100%">Rojas-Rueda, David</style></author><author><style face="normal" font="default" size="100%">Ronfani, Luca</style></author><author><style face="normal" font="default" size="100%">Roth, Gregory A</style></author><author><style face="normal" font="default" size="100%">Rothenbacher, Dietrich</style></author><author><style face="normal" font="default" size="100%">Rothstein, David H</style></author><author><style face="normal" font="default" size="100%">Rowley, Jane T</style></author><author><style face="normal" font="default" size="100%">Roy, Nobhojit</style></author><author><style face="normal" font="default" size="100%">Ruhago, George M</style></author><author><style face="normal" font="default" size="100%">Saeedi, Mohammad Y</style></author><author><style face="normal" font="default" size="100%">Saha, Sukanta</style></author><author><style face="normal" font="default" size="100%">Sahraian, Mohammad Ali</style></author><author><style face="normal" font="default" size="100%">Sampson, Uchechukwu K A</style></author><author><style face="normal" font="default" size="100%">Sanabria, Juan R</style></author><author><style face="normal" font="default" size="100%">Sandar, Logan</style></author><author><style face="normal" font="default" size="100%">Santos, Itamar S</style></author><author><style face="normal" font="default" size="100%">Satpathy, Maheswar</style></author><author><style face="normal" font="default" size="100%">Sawhney, Monika</style></author><author><style face="normal" font="default" size="100%">Scarborough, Peter</style></author><author><style face="normal" font="default" size="100%">Schneider, Ione J</style></author><author><style face="normal" font="default" size="100%">Schöttker, Ben</style></author><author><style face="normal" font="default" size="100%">Schumacher, Austin E</style></author><author><style face="normal" font="default" size="100%">Schwebel, David C</style></author><author><style face="normal" font="default" size="100%">Scott, James G</style></author><author><style face="normal" font="default" size="100%">Seedat, Soraya</style></author><author><style face="normal" font="default" size="100%">Sepanlou, Sadaf G</style></author><author><style face="normal" font="default" size="100%">Serina, Peter T</style></author><author><style face="normal" font="default" size="100%">Servan-Mori, Edson E</style></author><author><style face="normal" font="default" size="100%">Shackelford, Katya A</style></author><author><style face="normal" font="default" size="100%">Shaheen, Amira</style></author><author><style face="normal" font="default" size="100%">Shahraz, Saeid</style></author><author><style face="normal" font="default" size="100%">Shamah Levy, Teresa</style></author><author><style face="normal" font="default" size="100%">Shangguan, Siyi</style></author><author><style face="normal" font="default" size="100%">She, Jun</style></author><author><style face="normal" font="default" size="100%">Sheikhbahaei, Sara</style></author><author><style face="normal" font="default" size="100%">Shi, Peilin</style></author><author><style face="normal" font="default" size="100%">Shibuya, Kenji</style></author><author><style face="normal" font="default" size="100%">Shinohara, Yukito</style></author><author><style face="normal" font="default" size="100%">Shiri, Rahman</style></author><author><style face="normal" font="default" size="100%">Shishani, Kawkab</style></author><author><style face="normal" font="default" size="100%">Shiue, Ivy</style></author><author><style face="normal" font="default" size="100%">Shrime, Mark G</style></author><author><style face="normal" font="default" size="100%">Sigfusdottir, Inga D</style></author><author><style face="normal" font="default" size="100%">Silberberg, Donald H</style></author><author><style face="normal" font="default" size="100%">Simard, Edgar P</style></author><author><style face="normal" font="default" size="100%">Sindi, Shireen</style></author><author><style face="normal" font="default" size="100%">Singh, Abhishek</style></author><author><style face="normal" font="default" size="100%">Singh, Jasvinder A</style></author><author><style face="normal" font="default" size="100%">Singh, Lavanya</style></author><author><style face="normal" font="default" size="100%">Skirbekk, Vegard</style></author><author><style face="normal" font="default" size="100%">Slepak, Erica Leigh</style></author><author><style face="normal" font="default" size="100%">Sliwa, Karen</style></author><author><style face="normal" font="default" size="100%">Soneji, Samir</style></author><author><style face="normal" font="default" size="100%">Søreide, Kjetil</style></author><author><style face="normal" font="default" size="100%">Soshnikov, Sergey</style></author><author><style face="normal" font="default" size="100%">Sposato, Luciano A</style></author><author><style face="normal" font="default" size="100%">Sreeramareddy, Chandrashekhar T</style></author><author><style face="normal" font="default" size="100%">Stanaway, Jeffrey D</style></author><author><style face="normal" font="default" size="100%">Stathopoulou, Vasiliki</style></author><author><style face="normal" font="default" size="100%">Stein, Dan J</style></author><author><style face="normal" font="default" size="100%">Stein, Murray B</style></author><author><style face="normal" font="default" size="100%">Steiner, Caitlyn</style></author><author><style face="normal" font="default" size="100%">Steiner, Timothy J</style></author><author><style face="normal" font="default" size="100%">Stevens, Antony</style></author><author><style face="normal" font="default" size="100%">Stewart, Andrea</style></author><author><style face="normal" font="default" size="100%">Stovner, Lars J</style></author><author><style face="normal" font="default" size="100%">Stroumpoulis, Konstantinos</style></author><author><style face="normal" font="default" size="100%">Sunguya, Bruno F</style></author><author><style face="normal" font="default" size="100%">Swaminathan, Soumya</style></author><author><style face="normal" font="default" size="100%">Swaroop, Mamta</style></author><author><style face="normal" font="default" size="100%">Sykes, Bryan L</style></author><author><style face="normal" font="default" size="100%">Tabb, Karen M</style></author><author><style face="normal" font="default" size="100%">Takahashi, Ken</style></author><author><style face="normal" font="default" size="100%">Tandon, Nikhil</style></author><author><style face="normal" font="default" size="100%">Tanne, David</style></author><author><style face="normal" font="default" size="100%">Tanner, Marcel</style></author><author><style face="normal" font="default" size="100%">Tavakkoli, Mohammad</style></author><author><style face="normal" font="default" size="100%">Taylor, Hugh R</style></author><author><style face="normal" font="default" size="100%">Te Ao, Braden J</style></author><author><style face="normal" font="default" size="100%">Tediosi, Fabrizio</style></author><author><style face="normal" font="default" size="100%">Temesgen, Awoke M</style></author><author><style face="normal" font="default" size="100%">Templin, Tara</style></author><author><style face="normal" font="default" size="100%">Ten Have, Margreet</style></author><author><style face="normal" font="default" size="100%">Tenkorang, Eric Y</style></author><author><style face="normal" font="default" size="100%">Terkawi, Abdullah S</style></author><author><style face="normal" font="default" size="100%">Thomson, Blake</style></author><author><style face="normal" font="default" size="100%">Thorne-Lyman, Andrew L</style></author><author><style face="normal" font="default" size="100%">Thrift, Amanda G</style></author><author><style face="normal" font="default" size="100%">Thurston, George D</style></author><author><style face="normal" font="default" size="100%">Tillmann, Taavi</style></author><author><style face="normal" font="default" size="100%">Tonelli, Marcello</style></author><author><style face="normal" font="default" size="100%">Topouzis, Fotis</style></author><author><style face="normal" font="default" size="100%">Toyoshima, Hideaki</style></author><author><style face="normal" font="default" size="100%">Traebert, Jefferson</style></author><author><style face="normal" font="default" size="100%">Tran, Bach X</style></author><author><style face="normal" font="default" size="100%">Trillini, Matias</style></author><author><style face="normal" font="default" size="100%">Truelsen, Thomas</style></author><author><style face="normal" font="default" size="100%">Tsilimbaris, Miltiadis</style></author><author><style face="normal" font="default" size="100%">Tuzcu, Emin M</style></author><author><style face="normal" font="default" size="100%">Uchendu, Uche S</style></author><author><style face="normal" font="default" size="100%">Ukwaja, Kingsley N</style></author><author><style face="normal" font="default" size="100%">Undurraga, Eduardo A</style></author><author><style face="normal" font="default" size="100%">Uzun, Selen B</style></author><author><style face="normal" font="default" size="100%">Van Brakel, Wim H</style></author><author><style face="normal" font="default" size="100%">van de Vijver, Steven</style></author><author><style face="normal" font="default" size="100%">van Gool, Coen H</style></author><author><style face="normal" font="default" size="100%">van Os, Jim</style></author><author><style face="normal" font="default" size="100%">Vasankari, Tommi J</style></author><author><style face="normal" font="default" size="100%">Venketasubramanian, N</style></author><author><style face="normal" font="default" size="100%">Violante, Francesco S</style></author><author><style face="normal" font="default" size="100%">Vlassov, Vasiliy V</style></author><author><style face="normal" font="default" size="100%">Vollset, Stein Emil</style></author><author><style face="normal" font="default" size="100%">Wagner, Gregory R</style></author><author><style face="normal" font="default" size="100%">Wagner, Joseph</style></author><author><style face="normal" font="default" size="100%">Waller, Stephen G</style></author><author><style face="normal" font="default" size="100%">Wan, Xia</style></author><author><style face="normal" font="default" size="100%">Wang, Haidong</style></author><author><style face="normal" font="default" size="100%">Wang, JianLi</style></author><author><style face="normal" font="default" size="100%">Wang, Linhong</style></author><author><style face="normal" font="default" size="100%">Warouw, Tati S</style></author><author><style face="normal" font="default" size="100%">Weichenthal, Scott</style></author><author><style face="normal" font="default" size="100%">Weiderpass, Elisabete</style></author><author><style face="normal" font="default" size="100%">Weintraub, Robert G</style></author><author><style face="normal" font="default" size="100%">Wenzhi, Wang</style></author><author><style face="normal" font="default" size="100%">Werdecker, Andrea</style></author><author><style face="normal" font="default" size="100%">Westerman, Ronny</style></author><author><style face="normal" font="default" size="100%">Whiteford, Harvey A</style></author><author><style face="normal" font="default" size="100%">Wilkinson, James D</style></author><author><style face="normal" font="default" size="100%">Williams, Thomas N</style></author><author><style face="normal" font="default" size="100%">Wolfe, Charles D</style></author><author><style face="normal" font="default" size="100%">Wolock, Timothy M</style></author><author><style face="normal" font="default" size="100%">Woolf, Anthony D</style></author><author><style face="normal" font="default" size="100%">Wulf, Sarah</style></author><author><style face="normal" font="default" size="100%">Wurtz, Brittany</style></author><author><style face="normal" font="default" size="100%">Xu, Gelin</style></author><author><style face="normal" font="default" size="100%">Yan, Lijing L</style></author><author><style face="normal" font="default" size="100%">Yano, Yuichiro</style></author><author><style face="normal" font="default" size="100%">Ye, Pengpeng</style></author><author><style face="normal" font="default" size="100%">Yentür, Gökalp K</style></author><author><style face="normal" font="default" size="100%">Yip, Paul</style></author><author><style face="normal" font="default" size="100%">Yonemoto, Naohiro</style></author><author><style face="normal" font="default" size="100%">Yoon, Seok-Jun</style></author><author><style face="normal" font="default" size="100%">Younis, Mustafa Z</style></author><author><style face="normal" font="default" size="100%">Yu, Chuanhua</style></author><author><style face="normal" font="default" size="100%">Zaki, Maysaa E</style></author><author><style face="normal" font="default" size="100%">Zhao, Yong</style></author><author><style face="normal" font="default" size="100%">Zheng, Yingfeng</style></author><author><style face="normal" font="default" size="100%">Zonies, David</style></author><author><style face="normal" font="default" size="100%">Zou, Xiaonong</style></author><author><style face="normal" font="default" size="100%">Salomon, Joshua A</style></author><author><style face="normal" font="default" size="100%">Lopez, Alan D</style></author><author><style face="normal" font="default" size="100%">Vos, Theo</style></author></authors><translated-authors><author><style face="normal" font="default" size="100%">GBD 2013 DALYs and HALE Collaborators</style></author></translated-authors></contributors><titles><title><style face="normal" font="default" size="100%">Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990-2013: quantifying the epidemiological transition.</style></title><secondary-title><style face="normal" font="default" size="100%">Lancet</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Lancet</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Aged</style></keyword><keyword><style  face="normal" font="default" size="100%">Chronic Disease</style></keyword><keyword><style  face="normal" font="default" size="100%">Communicable Diseases</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">Global Health</style></keyword><keyword><style  face="normal" font="default" size="100%">Health Transition</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Life Expectancy</style></keyword><keyword><style  face="normal" font="default" size="100%">Male</style></keyword><keyword><style  face="normal" font="default" size="100%">Middle Aged</style></keyword><keyword><style  face="normal" font="default" size="100%">Mortality, Premature</style></keyword><keyword><style  face="normal" font="default" size="100%">Quality-Adjusted Life Years</style></keyword><keyword><style  face="normal" font="default" size="100%">Socioeconomic Factors</style></keyword><keyword><style  face="normal" font="default" size="100%">Wounds and Injuries</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2015 Nov 28</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">386</style></volume><pages><style face="normal" font="default" size="100%">2145-91</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;b&gt;BACKGROUND: &lt;/b&gt;The Global Burden of Disease Study 2013 (GBD 2013) aims to bring together all available epidemiological data using a coherent measurement framework, standardised estimation methods, and transparent data sources to enable comparisons of health loss over time and across causes, age-sex groups, and countries. The GBD can be used to generate summary measures such as disability-adjusted life-years (DALYs) and healthy life expectancy (HALE) that make possible comparative assessments of broad epidemiological patterns across countries and time. These summary measures can also be used to quantify the component of variation in epidemiology that is related to sociodemographic development.&lt;/p&gt;&lt;p&gt;&lt;b&gt;METHODS: &lt;/b&gt;We used the published GBD 2013 data for age-specific mortality, years of life lost due to premature mortality (YLLs), and years lived with disability (YLDs) to calculate DALYs and HALE for 1990, 1995, 2000, 2005, 2010, and 2013 for 188 countries. We calculated HALE using the Sullivan method; 95% uncertainty intervals (UIs) represent uncertainty in age-specific death rates and YLDs per person for each country, age, sex, and year. We estimated DALYs for 306 causes for each country as the sum of YLLs and YLDs; 95% UIs represent uncertainty in YLL and YLD rates. We quantified patterns of the epidemiological transition with a composite indicator of sociodemographic status, which we constructed from income per person, average years of schooling after age 15 years, and the total fertility rate and mean age of the population. We applied hierarchical regression to DALY rates by cause across countries to decompose variance related to the sociodemographic status variable, country, and time.&lt;/p&gt;&lt;p&gt;&lt;b&gt;FINDINGS: &lt;/b&gt;Worldwide, from 1990 to 2013, life expectancy at birth rose by 6·2 years (95% UI 5·6-6·6), from 65·3 years (65·0-65·6) in 1990 to 71·5 years (71·0-71·9) in 2013, HALE at birth rose by 5·4 years (4·9-5·8), from 56·9 years (54·5-59·1) to 62·3 years (59·7-64·8), total DALYs fell by 3·6% (0·3-7·4), and age-standardised DALY rates per 100 000 people fell by 26·7% (24·6-29·1). For communicable, maternal, neonatal, and nutritional disorders, global DALY numbers, crude rates, and age-standardised rates have all declined between 1990 and 2013, whereas for non-communicable diseases, global DALYs have been increasing, DALY rates have remained nearly constant, and age-standardised DALY rates declined during the same period. From 2005 to 2013, the number of DALYs increased for most specific non-communicable diseases, including cardiovascular diseases and neoplasms, in addition to dengue, food-borne trematodes, and leishmaniasis; DALYs decreased for nearly all other causes. By 2013, the five leading causes of DALYs were ischaemic heart disease, lower respiratory infections, cerebrovascular disease, low back and neck pain, and road injuries. Sociodemographic status explained more than 50% of the variance between countries and over time for diarrhoea, lower respiratory infections, and other common infectious diseases; maternal disorders; neonatal disorders; nutritional deficiencies; other communicable, maternal, neonatal, and nutritional diseases; musculoskeletal disorders; and other non-communicable diseases. However, sociodemographic status explained less than 10% of the variance in DALY rates for cardiovascular diseases; chronic respiratory diseases; cirrhosis; diabetes, urogenital, blood, and endocrine diseases; unintentional injuries; and self-harm and interpersonal violence. Predictably, increased sociodemographic status was associated with a shift in burden from YLLs to YLDs, driven by declines in YLLs and increases in YLDs from musculoskeletal disorders, neurological disorders, and mental and substance use disorders. In most country-specific estimates, the increase in life expectancy was greater than that in HALE. Leading causes of DALYs are highly variable across countries.&lt;/p&gt;&lt;p&gt;&lt;b&gt;INTERPRETATION: &lt;/b&gt;Global health is improving. Population growth and ageing have driven up numbers of DALYs, but crude rates have remained relatively constant, showing that progress in health does not mean fewer demands on health systems. The notion of an epidemiological transition--in which increasing sociodemographic status brings structured change in disease burden--is useful, but there is tremendous variation in burden of disease that is not associated with sociodemographic status. This further underscores the need for country-specific assessments of DALYs and HALE to appropriately inform health policy decisions and attendant actions.&lt;/p&gt;&lt;p&gt;&lt;b&gt;FUNDING: &lt;/b&gt;Bill &amp; Melinda Gates Foundation.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">10009</style></issue><custom1><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/26321261?dopt=Abstract</style></custom1></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Cavalcanti, Catarina Addobbati Jordão</style></author><author><style face="normal" font="default" size="100%">De Azevêdo Silva, Jaqueline</style></author><author><style face="normal" font="default" size="100%">de Barros Pita, Will</style></author><author><style face="normal" font="default" size="100%">Veit, Tiago Degani</style></author><author><style face="normal" font="default" size="100%">Monticielo, Odirlei Andre</style></author><author><style face="normal" font="default" size="100%">Xavier, Ricardo Machado</style></author><author><style face="normal" font="default" size="100%">Brenol, João Carlos Tavares</style></author><author><style face="normal" font="default" size="100%">Brenol, Cleiton Viegas</style></author><author><style face="normal" font="default" size="100%">Fragoso, Thiago Sotero</style></author><author><style face="normal" font="default" size="100%">Barbosa, Alexandre Domingues</style></author><author><style face="normal" font="default" size="100%">Duarte, Ângela Luiza Branco Pinto</style></author><author><style face="normal" font="default" size="100%">Oliveira, Renê Donizeti Ribeiro</style></author><author><style face="normal" font="default" size="100%">Louzada-Júnior, Paulo</style></author><author><style face="normal" font="default" size="100%">Donadi, Eduardo Antônio</style></author><author><style face="normal" font="default" size="100%">Crovella, Sergio</style></author><author><style face="normal" font="default" size="100%">Chies, José Artur Bogo</style></author><author><style face="normal" font="default" size="100%">Sandrin-Garcia, Paula</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Vitamin D receptor polymorphisms and expression profile in rheumatoid arthritis brazilian patients.</style></title><secondary-title><style face="normal" font="default" size="100%">Mol Biol Rep</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Mol. Biol. Rep.</style></alt-title></titles><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2015 Dec 19</style></date></pub-dates></dates><language><style face="normal" font="default" size="100%">ENG</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation and important joint commitment, being the most common systemic autoimmune disease worldwide. RA displays important genetic background with a variety of genes contributing to the immune balance breakdown. Recent studies have demonstrated that vitamin D, through its receptor (VDR), is able to regulate the immune balance and suppress the autoimmunity process, being a potential target in autoimmune diseases. In the present genetic association study, we assessed 5 Tag single nucleotide polymorphisms (SNPs) (rs11168268, rs2248098, rs1540339, rs4760648 and rs3890733), which cover most of the VDR gene, in three different Brazilian populations (from Northeast, Southeast and South Brazil). We also evaluated the VDR expression profile in whole blood and monocytes from RA patients. For genotyping study, 428 RA patients and 616 healthy controls were genotyped with fluorogenic allele specific probes on an ABI7500 platform. For gene expression study, VDR mRNA levels of 15 RA patients and 26 healthy individuals were assessed by RT-PCR. Our results showed that SNPs rs4760648 and rs3890733 are associated to RA susceptibility (p value = 0.0026, OR 1.31 and p value = 0.0091, OR 1.28 with statistical power = 0.999 and 0.993, respectively). Regarding RA clinical features, the studied SNPs did not show significant associations. The gene expression assays showed that VDR mRNA levels were down regulated in both whole blood (-3.3 fold) and monocytes (-3.2 fold) of RA patients when compared to healthy controls. Our results, the first reported for distinct Brazilian populations, support a role of the VDR gene in the susceptibility to RA.&lt;/p&gt;</style></abstract><custom1><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/26686848?dopt=Abstract</style></custom1></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Murray, Christopher J L</style></author><author><style face="normal" font="default" size="100%">Ortblad, Katrina F</style></author><author><style face="normal" font="default" size="100%">Guinovart, Caterina</style></author><author><style face="normal" font="default" size="100%">Lim, Stephen S</style></author><author><style face="normal" font="default" size="100%">Wolock, Timothy M</style></author><author><style face="normal" font="default" size="100%">Roberts, D Allen</style></author><author><style face="normal" font="default" size="100%">Dansereau, Emily A</style></author><author><style face="normal" font="default" size="100%">Graetz, Nicholas</style></author><author><style face="normal" font="default" size="100%">Barber, Ryan M</style></author><author><style face="normal" font="default" size="100%">Brown, Jonathan C</style></author><author><style face="normal" font="default" size="100%">Wang, Haidong</style></author><author><style face="normal" font="default" size="100%">Duber, Herbert C</style></author><author><style face="normal" font="default" size="100%">Naghavi, Mohsen</style></author><author><style face="normal" font="default" size="100%">Dicker, Daniel</style></author><author><style face="normal" font="default" size="100%">Dandona, Lalit</style></author><author><style face="normal" font="default" size="100%">Salomon, Joshua A</style></author><author><style face="normal" font="default" size="100%">Heuton, Kyle R</style></author><author><style face="normal" font="default" size="100%">Foreman, Kyle</style></author><author><style face="normal" font="default" size="100%">Phillips, David E</style></author><author><style face="normal" font="default" size="100%">Fleming, Thomas D</style></author><author><style face="normal" font="default" size="100%">Flaxman, Abraham D</style></author><author><style face="normal" font="default" size="100%">Phillips, Bryan K</style></author><author><style face="normal" font="default" size="100%">Johnson, Elizabeth K</style></author><author><style face="normal" font="default" size="100%">Coggeshall, Megan S</style></author><author><style face="normal" font="default" size="100%">Abd-Allah, Foad</style></author><author><style face="normal" font="default" size="100%">Abera, Semaw Ferede</style></author><author><style face="normal" font="default" size="100%">Abraham, Jerry P</style></author><author><style face="normal" font="default" size="100%">Abubakar, Ibrahim</style></author><author><style face="normal" font="default" size="100%">Abu-Raddad, Laith J</style></author><author><style face="normal" font="default" size="100%">Abu-Rmeileh, Niveen Me</style></author><author><style face="normal" font="default" size="100%">Achoki, Tom</style></author><author><style face="normal" font="default" size="100%">Adeyemo, Austine Olufemi</style></author><author><style face="normal" font="default" size="100%">Adou, Arsène Kouablan</style></author><author><style face="normal" font="default" size="100%">Adsuar, José C</style></author><author><style face="normal" font="default" size="100%">Agardh, Emilie Elisabet</style></author><author><style face="normal" font="default" size="100%">Akena, Dickens</style></author><author><style face="normal" font="default" size="100%">Al Kahbouri, Mazin J</style></author><author><style face="normal" font="default" size="100%">Alasfoor, Deena</style></author><author><style face="normal" font="default" size="100%">Albittar, Mohammed I</style></author><author><style face="normal" font="default" size="100%">Alcalá-Cerra, Gabriel</style></author><author><style face="normal" font="default" size="100%">Alegretti, Miguel Angel</style></author><author><style face="normal" font="default" size="100%">Alemu, Zewdie Aderaw</style></author><author><style face="normal" font="default" size="100%">Alfonso-Cristancho, Rafael</style></author><author><style face="normal" font="default" size="100%">Alhabib, Samia</style></author><author><style face="normal" font="default" size="100%">Ali, Raghib</style></author><author><style face="normal" font="default" size="100%">Alla, François</style></author><author><style face="normal" font="default" size="100%">Allen, Peter J</style></author><author><style face="normal" font="default" size="100%">Alsharif, Ubai</style></author><author><style face="normal" font="default" size="100%">Alvarez, Elena</style></author><author><style face="normal" font="default" size="100%">Alvis-Guzmán, Nelson</style></author><author><style face="normal" font="default" size="100%">Amankwaa, Adansi A</style></author><author><style face="normal" font="default" size="100%">Amare, Azmeraw T</style></author><author><style face="normal" font="default" size="100%">Amini, Hassan</style></author><author><style face="normal" font="default" size="100%">Ammar, Walid</style></author><author><style face="normal" font="default" size="100%">Anderson, Benjamin O</style></author><author><style face="normal" font="default" size="100%">Antonio, Carl Abelardo T</style></author><author><style face="normal" font="default" size="100%">Anwari, Palwasha</style></author><author><style face="normal" font="default" size="100%">Arnlöv, Johan</style></author><author><style face="normal" font="default" size="100%">Arsenijevic, Valentina S Arsic</style></author><author><style face="normal" font="default" size="100%">Artaman, Ali</style></author><author><style face="normal" font="default" size="100%">Asghar, Rana J</style></author><author><style face="normal" font="default" size="100%">Assadi, Reza</style></author><author><style face="normal" font="default" size="100%">Atkins, Lydia S</style></author><author><style face="normal" font="default" size="100%">Badawi, Alaa</style></author><author><style face="normal" font="default" size="100%">Balakrishnan, Kalpana</style></author><author><style face="normal" font="default" size="100%">Banerjee, Amitava</style></author><author><style face="normal" font="default" size="100%">Basu, Sanjay</style></author><author><style face="normal" font="default" size="100%">Beardsley, Justin</style></author><author><style face="normal" font="default" size="100%">Bekele, Tolesa</style></author><author><style face="normal" font="default" size="100%">Bell, Michelle L</style></author><author><style face="normal" font="default" size="100%">Bernabe, Eduardo</style></author><author><style face="normal" font="default" size="100%">Beyene, Tariku Jibat</style></author><author><style face="normal" font="default" size="100%">Bhala, Neeraj</style></author><author><style face="normal" font="default" size="100%">Bhalla, Ashish</style></author><author><style face="normal" font="default" size="100%">Bhutta, Zulfiqar A</style></author><author><style face="normal" font="default" size="100%">Abdulhak, Aref Bin</style></author><author><style face="normal" font="default" size="100%">Binagwaho, Agnes</style></author><author><style face="normal" font="default" size="100%">Blore, Jed D</style></author><author><style face="normal" font="default" size="100%">Basara, Berrak Bora</style></author><author><style face="normal" font="default" size="100%">Bose, Dipan</style></author><author><style face="normal" font="default" size="100%">Brainin, Michael</style></author><author><style face="normal" font="default" size="100%">Breitborde, Nicholas</style></author><author><style face="normal" font="default" size="100%">Castañeda-Orjuela, Carlos A</style></author><author><style face="normal" font="default" size="100%">Catalá-López, Ferrán</style></author><author><style face="normal" font="default" size="100%">Chadha, Vineet K</style></author><author><style face="normal" font="default" size="100%">Chang, Jung-Chen</style></author><author><style face="normal" font="default" size="100%">Chiang, Peggy Pei-Chia</style></author><author><style face="normal" font="default" size="100%">Chuang, Ting-Wu</style></author><author><style face="normal" font="default" size="100%">Colomar, Mercedes</style></author><author><style face="normal" font="default" size="100%">Cooper, Leslie Trumbull</style></author><author><style face="normal" font="default" size="100%">Cooper, Cyrus</style></author><author><style face="normal" font="default" size="100%">Courville, Karen J</style></author><author><style face="normal" font="default" size="100%">Cowie, Benjamin C</style></author><author><style face="normal" font="default" size="100%">Criqui, Michael H</style></author><author><style face="normal" font="default" size="100%">Dandona, Rakhi</style></author><author><style face="normal" font="default" size="100%">Dayama, Anand</style></author><author><style face="normal" font="default" size="100%">De Leo, Diego</style></author><author><style face="normal" font="default" size="100%">Degenhardt, Louisa</style></author><author><style face="normal" font="default" size="100%">del Pozo-Cruz, Borja</style></author><author><style face="normal" font="default" size="100%">Deribe, Kebede</style></author><author><style face="normal" font="default" size="100%">Des Jarlais, Don C</style></author><author><style face="normal" font="default" size="100%">Dessalegn, Muluken</style></author><author><style face="normal" font="default" size="100%">Dharmaratne, Samath D</style></author><author><style face="normal" font="default" size="100%">Dilmen, Uğur</style></author><author><style face="normal" font="default" size="100%">Ding, Eric L</style></author><author><style face="normal" font="default" size="100%">Driscoll, Tim R</style></author><author><style face="normal" font="default" size="100%">Durrani, Adnan M</style></author><author><style face="normal" font="default" size="100%">Ellenbogen, Richard G</style></author><author><style face="normal" font="default" size="100%">Ermakov, Sergey Petrovich</style></author><author><style face="normal" font="default" size="100%">Esteghamati, Alireza</style></author><author><style face="normal" font="default" size="100%">Faraon, Emerito Jose A</style></author><author><style face="normal" font="default" size="100%">Farzadfar, Farshad</style></author><author><style face="normal" font="default" size="100%">Fereshtehnejad, Seyed-Mohammad</style></author><author><style face="normal" font="default" size="100%">Fijabi, Daniel Obadare</style></author><author><style face="normal" font="default" size="100%">Forouzanfar, Mohammad H</style></author><author><style face="normal" font="default" size="100%">Fra Paleo, Urbano</style></author><author><style face="normal" font="default" size="100%">Gaffikin, Lynne</style></author><author><style face="normal" font="default" size="100%">Gamkrelidze, Amiran</style></author><author><style face="normal" font="default" size="100%">Gankpé, Fortuné Gbètoho</style></author><author><style face="normal" font="default" size="100%">Geleijnse, Johanna M</style></author><author><style face="normal" font="default" size="100%">Gessner, Bradford D</style></author><author><style face="normal" font="default" size="100%">Gibney, Katherine B</style></author><author><style face="normal" font="default" size="100%">Ginawi, Ibrahim Abdelmageem Mohamed</style></author><author><style face="normal" font="default" size="100%">Glaser, Elizabeth L</style></author><author><style face="normal" font="default" size="100%">Gona, Philimon</style></author><author><style face="normal" font="default" size="100%">Goto, Atsushi</style></author><author><style face="normal" font="default" size="100%">Gouda, Hebe N</style></author><author><style face="normal" font="default" size="100%">Gugnani, Harish Chander</style></author><author><style face="normal" font="default" size="100%">Gupta, Rajeev</style></author><author><style face="normal" font="default" size="100%">Gupta, Rahul</style></author><author><style face="normal" font="default" size="100%">Hafezi-Nejad, Nima</style></author><author><style face="normal" font="default" size="100%">Hamadeh, Randah Ribhi</style></author><author><style face="normal" font="default" size="100%">Hammami, Mouhanad</style></author><author><style face="normal" font="default" size="100%">Hankey, Graeme J</style></author><author><style face="normal" font="default" size="100%">Harb, Hilda L</style></author><author><style face="normal" font="default" size="100%">Haro, Josep Maria</style></author><author><style face="normal" font="default" size="100%">Havmoeller, Rasmus</style></author><author><style face="normal" font="default" size="100%">Hay, Simon I</style></author><author><style face="normal" font="default" size="100%">Hedayati, Mohammad T</style></author><author><style face="normal" font="default" size="100%">Pi, Ileana B Heredia</style></author><author><style face="normal" font="default" size="100%">Hoek, Hans W</style></author><author><style face="normal" font="default" size="100%">Hornberger, John C</style></author><author><style face="normal" font="default" size="100%">Hosgood, H Dean</style></author><author><style face="normal" font="default" size="100%">Hotez, Peter J</style></author><author><style face="normal" font="default" size="100%">Hoy, Damian G</style></author><author><style face="normal" font="default" size="100%">Huang, John J</style></author><author><style face="normal" font="default" size="100%">Iburg, Kim M</style></author><author><style face="normal" font="default" size="100%">Idrisov, Bulat T</style></author><author><style face="normal" font="default" size="100%">Innos, Kaire</style></author><author><style face="normal" font="default" size="100%">Jacobsen, Kathryn H</style></author><author><style face="normal" font="default" size="100%">Jeemon, Panniyammakal</style></author><author><style face="normal" font="default" size="100%">Jensen, Paul N</style></author><author><style face="normal" font="default" size="100%">Jha, Vivekanand</style></author><author><style face="normal" font="default" size="100%">Jiang, Guohong</style></author><author><style face="normal" font="default" size="100%">Jonas, Jost B</style></author><author><style face="normal" font="default" size="100%">Juel, Knud</style></author><author><style face="normal" font="default" size="100%">Kan, Haidong</style></author><author><style face="normal" font="default" size="100%">Kankindi, Ida</style></author><author><style face="normal" font="default" size="100%">Karam, Nadim E</style></author><author><style face="normal" font="default" size="100%">Karch, André</style></author><author><style face="normal" font="default" size="100%">Karema, Corine Kakizi</style></author><author><style face="normal" font="default" size="100%">Kaul, Anil</style></author><author><style face="normal" font="default" size="100%">Kawakami, Norito</style></author><author><style face="normal" font="default" size="100%">Kazi, Dhruv S</style></author><author><style face="normal" font="default" size="100%">Kemp, Andrew H</style></author><author><style face="normal" font="default" size="100%">Kengne, Andre Pascal</style></author><author><style face="normal" font="default" size="100%">Keren, Andre</style></author><author><style face="normal" font="default" size="100%">Kereselidze, Maia</style></author><author><style face="normal" font="default" size="100%">Khader, Yousef Saleh</style></author><author><style face="normal" font="default" size="100%">Khalifa, Shams Eldin Ali Hassan</style></author><author><style face="normal" font="default" size="100%">Khan, Ejaz Ahmed</style></author><author><style face="normal" font="default" size="100%">Khang, Young-Ho</style></author><author><style face="normal" font="default" size="100%">Khonelidze, Irma</style></author><author><style face="normal" font="default" size="100%">Kinfu, Yohannes</style></author><author><style face="normal" font="default" size="100%">Kinge, Jonas M</style></author><author><style face="normal" font="default" size="100%">Knibbs, Luke</style></author><author><style face="normal" font="default" size="100%">Kokubo, Yoshihiro</style></author><author><style face="normal" font="default" size="100%">Kosen, S</style></author><author><style face="normal" font="default" size="100%">Defo, Barthelemy Kuate</style></author><author><style face="normal" font="default" size="100%">Kulkarni, Veena S</style></author><author><style face="normal" font="default" size="100%">Kulkarni, Chanda</style></author><author><style face="normal" font="default" size="100%">Kumar, Kaushalendra</style></author><author><style face="normal" font="default" size="100%">Kumar, Ravi B</style></author><author><style face="normal" font="default" size="100%">Kumar, G Anil</style></author><author><style face="normal" font="default" size="100%">Kwan, Gene F</style></author><author><style face="normal" font="default" size="100%">Lai, Taavi</style></author><author><style face="normal" font="default" size="100%">Balaji, Arjun Lakshmana</style></author><author><style face="normal" font="default" size="100%">Lam, Hilton</style></author><author><style face="normal" font="default" size="100%">Lan, Qing</style></author><author><style face="normal" font="default" size="100%">Lansingh, Van C</style></author><author><style face="normal" font="default" size="100%">Larson, Heidi J</style></author><author><style face="normal" font="default" size="100%">Larsson, Anders</style></author><author><style face="normal" font="default" size="100%">Lee, Jong-Tae</style></author><author><style face="normal" font="default" size="100%">Leigh, James</style></author><author><style face="normal" font="default" size="100%">Leinsalu, Mall</style></author><author><style face="normal" font="default" size="100%">Leung, Ricky</style></author><author><style face="normal" font="default" size="100%">Li, Yichong</style></author><author><style face="normal" font="default" size="100%">Li, Yongmei</style></author><author><style face="normal" font="default" size="100%">de Lima, Graça Maria Ferreira</style></author><author><style face="normal" font="default" size="100%">Lin, Hsien-Ho</style></author><author><style face="normal" font="default" size="100%">Lipshultz, Steven E</style></author><author><style face="normal" font="default" size="100%">Liu, Shiwei</style></author><author><style face="normal" font="default" size="100%">Liu, Yang</style></author><author><style face="normal" font="default" size="100%">Lloyd, Belinda K</style></author><author><style face="normal" font="default" size="100%">Lotufo, Paulo A</style></author><author><style face="normal" font="default" size="100%">Machado, Vasco Manuel Pedro</style></author><author><style face="normal" font="default" size="100%">Maclachlan, Jennifer H</style></author><author><style face="normal" font="default" size="100%">Magis-Rodriguez, Carlos</style></author><author><style face="normal" font="default" size="100%">Majdan, Marek</style></author><author><style face="normal" font="default" size="100%">Mapoma, Christopher Chabila</style></author><author><style face="normal" font="default" size="100%">Marcenes, Wagner</style></author><author><style face="normal" font="default" size="100%">Marzan, Melvin Barrientos</style></author><author><style face="normal" font="default" size="100%">Masci, Joseph R</style></author><author><style face="normal" font="default" size="100%">Mashal, Mohammad Taufiq</style></author><author><style face="normal" font="default" size="100%">Mason-Jones, Amanda J</style></author><author><style face="normal" font="default" size="100%">Mayosi, Bongani M</style></author><author><style face="normal" font="default" size="100%">Mazorodze, Tasara T</style></author><author><style face="normal" font="default" size="100%">Mckay, Abigail Cecilia</style></author><author><style face="normal" font="default" size="100%">Meaney, Peter A</style></author><author><style face="normal" font="default" size="100%">Mehndiratta, Man Mohan</style></author><author><style face="normal" font="default" size="100%">Mejia-Rodriguez, Fabiola</style></author><author><style face="normal" font="default" size="100%">Melaku, Yohannes Adama</style></author><author><style face="normal" font="default" size="100%">Memish, Ziad A</style></author><author><style face="normal" font="default" size="100%">Mendoza, Walter</style></author><author><style face="normal" font="default" size="100%">Miller, Ted R</style></author><author><style face="normal" font="default" size="100%">Mills, Edward J</style></author><author><style face="normal" font="default" size="100%">Mohammad, Karzan Abdulmuhsin</style></author><author><style face="normal" font="default" size="100%">Mokdad, Ali H</style></author><author><style face="normal" font="default" size="100%">Mola, Glen Liddell</style></author><author><style face="normal" font="default" size="100%">Monasta, Lorenzo</style></author><author><style face="normal" font="default" size="100%">Montico, Marcella</style></author><author><style face="normal" font="default" size="100%">Moore, Ami R</style></author><author><style face="normal" font="default" size="100%">Mori, Rintaro</style></author><author><style face="normal" font="default" size="100%">Moturi, Wilkister Nyaora</style></author><author><style face="normal" font="default" size="100%">Mukaigawara, Mitsuru</style></author><author><style face="normal" font="default" size="100%">Murthy, Kinnari S</style></author><author><style face="normal" font="default" size="100%">Naheed, Aliya</style></author><author><style face="normal" font="default" size="100%">Naidoo, Kovin S</style></author><author><style face="normal" font="default" size="100%">Naldi, Luigi</style></author><author><style face="normal" font="default" size="100%">Nangia, Vinay</style></author><author><style face="normal" font="default" size="100%">Narayan, K M Venkat</style></author><author><style face="normal" font="default" size="100%">Nash, Denis</style></author><author><style face="normal" font="default" size="100%">Nejjari, Chakib</style></author><author><style face="normal" font="default" size="100%">Nelson, Robert G</style></author><author><style face="normal" font="default" size="100%">Neupane, Sudan Prasad</style></author><author><style face="normal" font="default" size="100%">Newton, Charles R</style></author><author><style face="normal" font="default" size="100%">Ng, Marie</style></author><author><style face="normal" font="default" size="100%">Nisar, Muhammad Imran</style></author><author><style face="normal" font="default" size="100%">Nolte, Sandra</style></author><author><style face="normal" font="default" size="100%">Norheim, Ole F</style></author><author><style face="normal" font="default" size="100%">Nowaseb, Vincent</style></author><author><style face="normal" font="default" size="100%">Nyakarahuka, Luke</style></author><author><style face="normal" font="default" size="100%">Oh, In-Hwan</style></author><author><style face="normal" font="default" size="100%">Ohkubo, Takayoshi</style></author><author><style face="normal" font="default" size="100%">Olusanya, Bolajoko O</style></author><author><style face="normal" font="default" size="100%">Omer, Saad B</style></author><author><style face="normal" font="default" size="100%">Opio, John Nelson</style></author><author><style face="normal" font="default" size="100%">Orisakwe, Orish Ebere</style></author><author><style face="normal" font="default" size="100%">Pandian, Jeyaraj D</style></author><author><style face="normal" font="default" size="100%">Papachristou, Christina</style></author><author><style face="normal" font="default" size="100%">Caicedo, Angel J Paternina</style></author><author><style face="normal" font="default" size="100%">Patten, Scott B</style></author><author><style face="normal" font="default" size="100%">Paul, Vinod K</style></author><author><style face="normal" font="default" size="100%">Pavlin, Boris Igor</style></author><author><style face="normal" font="default" size="100%">Pearce, Neil</style></author><author><style face="normal" font="default" size="100%">Pereira, David M</style></author><author><style face="normal" font="default" size="100%">Pervaiz, Aslam</style></author><author><style face="normal" font="default" size="100%">Pesudovs, Konrad</style></author><author><style face="normal" font="default" size="100%">Petzold, Max</style></author><author><style face="normal" font="default" size="100%">Pourmalek, Farshad</style></author><author><style face="normal" font="default" size="100%">Qato, Dima</style></author><author><style face="normal" font="default" size="100%">Quezada, Amado D</style></author><author><style face="normal" font="default" size="100%">Quistberg, D Alex</style></author><author><style face="normal" font="default" size="100%">Rafay, Anwar</style></author><author><style face="normal" font="default" size="100%">Rahimi, Kazem</style></author><author><style face="normal" font="default" size="100%">Rahimi-Movaghar, Vafa</style></author><author><style face="normal" font="default" size="100%">ur Rahman, Sajjad</style></author><author><style face="normal" font="default" size="100%">Raju, Murugesan</style></author><author><style face="normal" font="default" size="100%">Rana, Saleem M</style></author><author><style face="normal" font="default" size="100%">Razavi, Homie</style></author><author><style face="normal" font="default" size="100%">Reilly, Robert Quentin</style></author><author><style face="normal" font="default" size="100%">Remuzzi, Giuseppe</style></author><author><style face="normal" font="default" size="100%">Richardus, Jan Hendrik</style></author><author><style face="normal" font="default" size="100%">Ronfani, Luca</style></author><author><style face="normal" font="default" size="100%">Roy, Nobhojit</style></author><author><style face="normal" font="default" size="100%">Sabin, Nsanzimana</style></author><author><style face="normal" font="default" size="100%">Saeedi, Mohammad Yahya</style></author><author><style face="normal" font="default" size="100%">Sahraian, Mohammad Ali</style></author><author><style face="normal" font="default" size="100%">Samonte, Genesis May J</style></author><author><style face="normal" font="default" size="100%">Sawhney, Monika</style></author><author><style face="normal" font="default" size="100%">Schneider, Ione J C</style></author><author><style face="normal" font="default" size="100%">Schwebel, David C</style></author><author><style face="normal" font="default" size="100%">Seedat, Soraya</style></author><author><style face="normal" font="default" size="100%">Sepanlou, Sadaf G</style></author><author><style face="normal" font="default" size="100%">Servan-Mori, Edson E</style></author><author><style face="normal" font="default" size="100%">Sheikhbahaei, Sara</style></author><author><style face="normal" font="default" size="100%">Shibuya, Kenji</style></author><author><style face="normal" font="default" size="100%">Shin, Hwashin Hyun</style></author><author><style face="normal" font="default" size="100%">Shiue, Ivy</style></author><author><style face="normal" font="default" size="100%">Shivakoti, Rupak</style></author><author><style face="normal" font="default" size="100%">Sigfusdottir, Inga Dora</style></author><author><style face="normal" font="default" size="100%">Silberberg, Donald H</style></author><author><style face="normal" font="default" size="100%">Silva, Andrea P</style></author><author><style face="normal" font="default" size="100%">Simard, Edgar P</style></author><author><style face="normal" font="default" size="100%">Singh, Jasvinder A</style></author><author><style face="normal" font="default" size="100%">Skirbekk, Vegard</style></author><author><style face="normal" font="default" size="100%">Sliwa, Karen</style></author><author><style face="normal" font="default" size="100%">Soneji, Samir</style></author><author><style face="normal" font="default" size="100%">Soshnikov, Sergey S</style></author><author><style face="normal" font="default" size="100%">Sreeramareddy, Chandrashekhar T</style></author><author><style face="normal" font="default" size="100%">Stathopoulou, Vasiliki Kalliopi</style></author><author><style face="normal" font="default" size="100%">Stroumpoulis, Konstantinos</style></author><author><style face="normal" font="default" size="100%">Swaminathan, Soumya</style></author><author><style face="normal" font="default" size="100%">Sykes, Bryan L</style></author><author><style face="normal" font="default" size="100%">Tabb, Karen M</style></author><author><style face="normal" font="default" size="100%">Talongwa, Roberto Tchio</style></author><author><style face="normal" font="default" size="100%">Tenkorang, Eric Yeboah</style></author><author><style face="normal" font="default" size="100%">Terkawi, Abdullah Sulieman</style></author><author><style face="normal" font="default" size="100%">Thomson, Alan J</style></author><author><style face="normal" font="default" size="100%">Thorne-Lyman, Andrew L</style></author><author><style face="normal" font="default" size="100%">Towbin, Jeffrey A</style></author><author><style face="normal" font="default" size="100%">Traebert, Jefferson</style></author><author><style face="normal" font="default" size="100%">Tran, Bach X</style></author><author><style face="normal" font="default" size="100%">Dimbuene, Zacharie Tsala</style></author><author><style face="normal" font="default" size="100%">Tsilimbaris, Miltiadis</style></author><author><style face="normal" font="default" size="100%">Uchendu, Uche S</style></author><author><style face="normal" font="default" size="100%">Ukwaja, Kingsley N</style></author><author><style face="normal" font="default" size="100%">Uzun, Selen Begüm</style></author><author><style face="normal" font="default" size="100%">Vallely, Andrew J</style></author><author><style face="normal" font="default" size="100%">Vasankari, Tommi J</style></author><author><style face="normal" font="default" size="100%">Venketasubramanian, N</style></author><author><style face="normal" font="default" size="100%">Violante, Francesco S</style></author><author><style face="normal" font="default" size="100%">Vlassov, Vasiliy Victorovich</style></author><author><style face="normal" font="default" size="100%">Vollset, Stein Emil</style></author><author><style face="normal" font="default" size="100%">Waller, Stephen</style></author><author><style face="normal" font="default" size="100%">Wallin, Mitchell T</style></author><author><style face="normal" font="default" size="100%">Wang, Linhong</style></author><author><style face="normal" font="default" size="100%">Wang, XiaoRong</style></author><author><style face="normal" font="default" size="100%">Wang, Yanping</style></author><author><style face="normal" font="default" size="100%">Weichenthal, Scott</style></author><author><style face="normal" font="default" size="100%">Weiderpass, Elisabete</style></author><author><style face="normal" font="default" size="100%">Weintraub, Robert G</style></author><author><style face="normal" font="default" size="100%">Westerman, Ronny</style></author><author><style face="normal" font="default" size="100%">White, Richard A</style></author><author><style face="normal" font="default" size="100%">Wilkinson, James D</style></author><author><style face="normal" font="default" size="100%">Williams, Thomas Neil</style></author><author><style face="normal" font="default" size="100%">Woldeyohannes, Solomon Meseret</style></author><author><style face="normal" font="default" size="100%">Wong, John Q</style></author><author><style face="normal" font="default" size="100%">Xu, Gelin</style></author><author><style face="normal" font="default" size="100%">Yang, Yang C</style></author><author><style face="normal" font="default" size="100%">Yano, Yuichiro</style></author><author><style face="normal" font="default" size="100%">Yentur, Gokalp Kadri</style></author><author><style face="normal" font="default" size="100%">Yip, Paul</style></author><author><style face="normal" font="default" size="100%">Yonemoto, Naohiro</style></author><author><style face="normal" font="default" size="100%">Yoon, Seok-Jun</style></author><author><style face="normal" font="default" size="100%">Younis, Mustafa</style></author><author><style face="normal" font="default" size="100%">Yu, Chuanhua</style></author><author><style face="normal" font="default" size="100%">Jin, Kim Yun</style></author><author><style face="normal" font="default" size="100%">El Sayed Zaki, Maysaa</style></author><author><style face="normal" font="default" size="100%">Zhao, Yong</style></author><author><style face="normal" font="default" size="100%">Zheng, Yingfeng</style></author><author><style face="normal" font="default" size="100%">Zhou, Maigeng</style></author><author><style face="normal" font="default" size="100%">Zhu, Jun</style></author><author><style face="normal" font="default" size="100%">Zou, Xiao Nong</style></author><author><style face="normal" font="default" size="100%">Lopez, Alan D</style></author><author><style face="normal" font="default" size="100%">Vos, Theo</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Global, regional, and national incidence and mortality for HIV, tuberculosis, and malaria during 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013.</style></title><secondary-title><style face="normal" font="default" size="100%">Lancet</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Lancet</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Age Distribution</style></keyword><keyword><style  face="normal" font="default" size="100%">Epidemics</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">Global Health</style></keyword><keyword><style  face="normal" font="default" size="100%">HIV Infections</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Incidence</style></keyword><keyword><style  face="normal" font="default" size="100%">Malaria</style></keyword><keyword><style  face="normal" font="default" size="100%">Male</style></keyword><keyword><style  face="normal" font="default" size="100%">Mortality</style></keyword><keyword><style  face="normal" font="default" size="100%">Organizational Objectives</style></keyword><keyword><style  face="normal" font="default" size="100%">Sex Distribution</style></keyword><keyword><style  face="normal" font="default" size="100%">Tuberculosis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2014 Sep 13</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">384</style></volume><pages><style face="normal" font="default" size="100%">1005-70</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;b&gt;BACKGROUND: &lt;/b&gt;The Millennium Declaration in 2000 brought special global attention to HIV, tuberculosis, and malaria through the formulation of Millennium Development Goal (MDG) 6. The Global Burden of Disease 2013 study provides a consistent and comprehensive approach to disease estimation for between 1990 and 2013, and an opportunity to assess whether accelerated progress has occured since the Millennium Declaration.&lt;/p&gt;&lt;p&gt;&lt;b&gt;METHODS: &lt;/b&gt;To estimate incidence and mortality for HIV, we used the UNAIDS Spectrum model appropriately modified based on a systematic review of available studies of mortality with and without antiretroviral therapy (ART). For concentrated epidemics, we calibrated Spectrum models to fit vital registration data corrected for misclassification of HIV deaths. In generalised epidemics, we minimised a loss function to select epidemic curves most consistent with prevalence data and demographic data for all-cause mortality. We analysed counterfactual scenarios for HIV to assess years of life saved through prevention of mother-to-child transmission (PMTCT) and ART. For tuberculosis, we analysed vital registration and verbal autopsy data to estimate mortality using cause of death ensemble modelling. We analysed data for corrected case-notifications, expert opinions on the case-detection rate, prevalence surveys, and estimated cause-specific mortality using Bayesian meta-regression to generate consistent trends in all parameters. We analysed malaria mortality and incidence using an updated cause of death database, a systematic analysis of verbal autopsy validation studies for malaria, and recent studies (2010-13) of incidence, drug resistance, and coverage of insecticide-treated bednets.&lt;/p&gt;&lt;p&gt;&lt;b&gt;FINDINGS: &lt;/b&gt;Globally in 2013, there were 1·8 million new HIV infections (95% uncertainty interval 1·7 million to 2·1 million), 29·2 million prevalent HIV cases (28·1 to 31·7), and 1·3 million HIV deaths (1·3 to 1·5). At the peak of the epidemic in 2005, HIV caused 1·7 million deaths (1·6 million to 1·9 million). Concentrated epidemics in Latin America and eastern Europe are substantially smaller than previously estimated. Through interventions including PMTCT and ART, 19·1 million life-years (16·6 million to 21·5 million) have been saved, 70·3% (65·4 to 76·1) in developing countries. From 2000 to 2011, the ratio of development assistance for health for HIV to years of life saved through intervention was US$4498 in developing countries. Including in HIV-positive individuals, all-form tuberculosis incidence was 7·5 million (7·4 million to 7·7 million), prevalence was 11·9 million (11·6 million to 12·2 million), and number of deaths was 1·4 million (1·3 million to 1·5 million) in 2013. In the same year and in only individuals who were HIV-negative, all-form tuberculosis incidence was 7·1 million (6·9 million to 7·3 million), prevalence was 11·2 million (10·8 million to 11·6 million), and number of deaths was 1·3 million (1·2 million to 1·4 million). Annualised rates of change (ARC) for incidence, prevalence, and death became negative after 2000. Tuberculosis in HIV-negative individuals disproportionately occurs in men and boys (versus women and girls); 64·0% of cases (63·6 to 64·3) and 64·7% of deaths (60·8 to 70·3). Globally, malaria cases and deaths grew rapidly from 1990 reaching a peak of 232 million cases (143 million to 387 million) in 2003 and 1·2 million deaths (1·1 million to 1·4 million) in 2004. Since 2004, child deaths from malaria in sub-Saharan Africa have decreased by 31·5% (15·7 to 44·1). Outside of Africa, malaria mortality has been steadily decreasing since 1990.&lt;/p&gt;&lt;p&gt;&lt;b&gt;INTERPRETATION: &lt;/b&gt;Our estimates of the number of people living with HIV are 18·7% smaller than UNAIDS's estimates in 2012. The number of people living with malaria is larger than estimated by WHO. The number of people living with HIV, tuberculosis, or malaria have all decreased since 2000. At the global level, upward trends for malaria and HIV deaths have been reversed and declines in tuberculosis deaths have accelerated. 101 countries (74 of which are developing) still have increasing HIV incidence. Substantial progress since the Millennium Declaration is an encouraging sign of the effect of global action.&lt;/p&gt;&lt;p&gt;&lt;b&gt;FUNDING: &lt;/b&gt;Bill &amp; Melinda Gates Foundation.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">9947</style></issue><custom1><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/25059949?dopt=Abstract</style></custom1></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kassebaum, Nicholas J</style></author><author><style face="normal" font="default" size="100%">Bertozzi-Villa, Amelia</style></author><author><style face="normal" font="default" size="100%">Coggeshall, Megan S</style></author><author><style face="normal" font="default" size="100%">Shackelford, Katya A</style></author><author><style face="normal" font="default" size="100%">Steiner, Caitlyn</style></author><author><style face="normal" font="default" size="100%">Heuton, Kyle R</style></author><author><style face="normal" font="default" size="100%">Gonzalez-Medina, Diego</style></author><author><style face="normal" font="default" size="100%">Barber, Ryan</style></author><author><style face="normal" font="default" size="100%">Huynh, Chantal</style></author><author><style face="normal" font="default" size="100%">Dicker, Daniel</style></author><author><style face="normal" font="default" size="100%">Templin, Tara</style></author><author><style face="normal" font="default" size="100%">Wolock, Timothy M</style></author><author><style face="normal" font="default" size="100%">Ozgoren, Ayse Abbasoglu</style></author><author><style face="normal" font="default" size="100%">Abd-Allah, Foad</style></author><author><style face="normal" font="default" size="100%">Abera, Semaw Ferede</style></author><author><style face="normal" font="default" size="100%">Abubakar, Ibrahim</style></author><author><style face="normal" font="default" size="100%">Achoki, Tom</style></author><author><style face="normal" font="default" size="100%">Adelekan, Ademola</style></author><author><style face="normal" font="default" size="100%">Ademi, Zanfina</style></author><author><style face="normal" font="default" size="100%">Adou, Arsène Kouablan</style></author><author><style face="normal" font="default" size="100%">Adsuar, José C</style></author><author><style face="normal" font="default" size="100%">Agardh, Emilie E</style></author><author><style face="normal" font="default" size="100%">Akena, Dickens</style></author><author><style face="normal" font="default" size="100%">Alasfoor, Deena</style></author><author><style face="normal" font="default" size="100%">Alemu, Zewdie Aderaw</style></author><author><style face="normal" font="default" size="100%">Alfonso-Cristancho, Rafael</style></author><author><style face="normal" font="default" size="100%">Alhabib, Samia</style></author><author><style face="normal" font="default" size="100%">Ali, Raghib</style></author><author><style face="normal" font="default" size="100%">Al Kahbouri, Mazin J</style></author><author><style face="normal" font="default" size="100%">Alla, François</style></author><author><style face="normal" font="default" size="100%">Allen, Peter J</style></author><author><style face="normal" font="default" size="100%">AlMazroa, Mohammad A</style></author><author><style face="normal" font="default" size="100%">Alsharif, Ubai</style></author><author><style face="normal" font="default" size="100%">Alvarez, Elena</style></author><author><style face="normal" font="default" size="100%">Alvis-Guzmán, Nelson</style></author><author><style face="normal" font="default" size="100%">Amankwaa, Adansi A</style></author><author><style face="normal" font="default" size="100%">Amare, Azmeraw T</style></author><author><style face="normal" font="default" size="100%">Amini, Hassan</style></author><author><style face="normal" font="default" size="100%">Ammar, Walid</style></author><author><style face="normal" font="default" size="100%">Antonio, Carl A T</style></author><author><style face="normal" font="default" size="100%">Anwari, Palwasha</style></author><author><style face="normal" font="default" size="100%">Arnlöv, Johan</style></author><author><style face="normal" font="default" size="100%">Arsenijevic, Valentina S Arsic</style></author><author><style face="normal" font="default" size="100%">Artaman, Ali</style></author><author><style face="normal" font="default" size="100%">Asad, Majed Masoud</style></author><author><style face="normal" font="default" size="100%">Asghar, Rana J</style></author><author><style face="normal" font="default" size="100%">Assadi, Reza</style></author><author><style face="normal" font="default" size="100%">Atkins, Lydia S</style></author><author><style face="normal" font="default" size="100%">Badawi, Alaa</style></author><author><style face="normal" font="default" size="100%">Balakrishnan, Kalpana</style></author><author><style face="normal" font="default" size="100%">Basu, Arindam</style></author><author><style face="normal" font="default" size="100%">Basu, Sanjay</style></author><author><style face="normal" font="default" size="100%">Beardsley, Justin</style></author><author><style face="normal" font="default" size="100%">Bedi, Neeraj</style></author><author><style face="normal" font="default" size="100%">Bekele, Tolesa</style></author><author><style face="normal" font="default" size="100%">Bell, Michelle L</style></author><author><style face="normal" font="default" size="100%">Bernabe, Eduardo</style></author><author><style face="normal" font="default" size="100%">Beyene, Tariku J</style></author><author><style face="normal" font="default" size="100%">Bhutta, Zulfiqar</style></author><author><style face="normal" font="default" size="100%">Bin Abdulhak, Aref</style></author><author><style face="normal" font="default" size="100%">Blore, Jed D</style></author><author><style face="normal" font="default" size="100%">Basara, Berrak Bora</style></author><author><style face="normal" font="default" size="100%">Bose, Dipan</style></author><author><style face="normal" font="default" size="100%">Breitborde, Nicholas</style></author><author><style face="normal" font="default" size="100%">Cárdenas, Rosario</style></author><author><style face="normal" font="default" size="100%">Castañeda-Orjuela, Carlos A</style></author><author><style face="normal" font="default" size="100%">Castro, Ruben Estanislao</style></author><author><style face="normal" font="default" size="100%">Catalá-López, Ferrán</style></author><author><style face="normal" font="default" size="100%">Cavlin, Alanur</style></author><author><style face="normal" font="default" size="100%">Chang, Jung-Chen</style></author><author><style face="normal" font="default" size="100%">Che, Xuan</style></author><author><style face="normal" font="default" size="100%">Christophi, Costas A</style></author><author><style face="normal" font="default" size="100%">Chugh, Sumeet S</style></author><author><style face="normal" font="default" size="100%">Cirillo, Massimo</style></author><author><style face="normal" font="default" size="100%">Colquhoun, Samantha M</style></author><author><style face="normal" font="default" size="100%">Cooper, Leslie Trumbull</style></author><author><style face="normal" font="default" size="100%">Cooper, Cyrus</style></author><author><style face="normal" font="default" size="100%">da Costa Leite, Iuri</style></author><author><style face="normal" font="default" size="100%">Dandona, Lalit</style></author><author><style face="normal" font="default" size="100%">Dandona, Rakhi</style></author><author><style face="normal" font="default" size="100%">Davis, Adrian</style></author><author><style face="normal" font="default" size="100%">Dayama, Anand</style></author><author><style face="normal" font="default" size="100%">Degenhardt, Louisa</style></author><author><style face="normal" font="default" size="100%">De Leo, Diego</style></author><author><style face="normal" font="default" size="100%">del Pozo-Cruz, Borja</style></author><author><style face="normal" font="default" size="100%">Deribe, Kebede</style></author><author><style face="normal" font="default" size="100%">Dessalegn, Muluken</style></author><author><style face="normal" font="default" size="100%">deVeber, Gabrielle A</style></author><author><style face="normal" font="default" size="100%">Dharmaratne, Samath D</style></author><author><style face="normal" font="default" size="100%">Dilmen, Uğur</style></author><author><style face="normal" font="default" size="100%">Ding, Eric L</style></author><author><style face="normal" font="default" size="100%">Dorrington, Rob E</style></author><author><style face="normal" font="default" size="100%">Driscoll, Tim R</style></author><author><style face="normal" font="default" size="100%">Ermakov, Sergei Petrovich</style></author><author><style face="normal" font="default" size="100%">Esteghamati, Alireza</style></author><author><style face="normal" font="default" size="100%">Faraon, Emerito Jose A</style></author><author><style face="normal" font="default" size="100%">Farzadfar, Farshad</style></author><author><style face="normal" font="default" size="100%">Felicio, Manuela Mendonca</style></author><author><style face="normal" font="default" size="100%">Fereshtehnejad, Seyed-Mohammad</style></author><author><style face="normal" font="default" size="100%">de Lima, Graça Maria Ferreira</style></author><author><style face="normal" font="default" size="100%">Forouzanfar, Mohammad H</style></author><author><style face="normal" font="default" size="100%">França, Elisabeth B</style></author><author><style face="normal" font="default" size="100%">Gaffikin, Lynne</style></author><author><style face="normal" font="default" size="100%">Gambashidze, Ketevan</style></author><author><style face="normal" font="default" size="100%">Gankpé, Fortuné Gbètoho</style></author><author><style face="normal" font="default" size="100%">Garcia, Ana C</style></author><author><style face="normal" font="default" size="100%">Geleijnse, Johanna M</style></author><author><style face="normal" font="default" size="100%">Gibney, Katherine B</style></author><author><style face="normal" font="default" size="100%">Giroud, Maurice</style></author><author><style face="normal" font="default" size="100%">Glaser, Elizabeth L</style></author><author><style face="normal" font="default" size="100%">Goginashvili, Ketevan</style></author><author><style face="normal" font="default" size="100%">Gona, Philimon</style></author><author><style face="normal" font="default" size="100%">González-Castell, Dinorah</style></author><author><style face="normal" font="default" size="100%">Goto, Atsushi</style></author><author><style face="normal" font="default" size="100%">Gouda, Hebe N</style></author><author><style face="normal" font="default" size="100%">Gugnani, Harish Chander</style></author><author><style face="normal" font="default" size="100%">Gupta, Rahul</style></author><author><style face="normal" font="default" size="100%">Gupta, Rajeev</style></author><author><style face="normal" font="default" size="100%">Hafezi-Nejad, Nima</style></author><author><style face="normal" font="default" size="100%">Hamadeh, Randah Ribhi</style></author><author><style face="normal" font="default" size="100%">Hammami, Mouhanad</style></author><author><style face="normal" font="default" size="100%">Hankey, Graeme J</style></author><author><style face="normal" font="default" size="100%">Harb, Hilda L</style></author><author><style face="normal" font="default" size="100%">Havmoeller, Rasmus</style></author><author><style face="normal" font="default" size="100%">Hay, Simon I</style></author><author><style face="normal" font="default" size="100%">Pi, Ileana B Heredia</style></author><author><style face="normal" font="default" size="100%">Hoek, Hans W</style></author><author><style face="normal" font="default" size="100%">Hosgood, H Dean</style></author><author><style face="normal" font="default" size="100%">Hoy, Damian G</style></author><author><style face="normal" font="default" size="100%">Husseini, Abdullatif</style></author><author><style face="normal" font="default" size="100%">Idrisov, Bulat T</style></author><author><style face="normal" font="default" size="100%">Innos, Kaire</style></author><author><style face="normal" font="default" size="100%">Inoue, Manami</style></author><author><style face="normal" font="default" size="100%">Jacobsen, Kathryn H</style></author><author><style face="normal" font="default" size="100%">Jahangir, Eiman</style></author><author><style face="normal" font="default" size="100%">Jee, Sun Ha</style></author><author><style face="normal" font="default" size="100%">Jensen, Paul N</style></author><author><style face="normal" font="default" size="100%">Jha, Vivekanand</style></author><author><style face="normal" font="default" size="100%">Jiang, Guohong</style></author><author><style face="normal" font="default" size="100%">Jonas, Jost B</style></author><author><style face="normal" font="default" size="100%">Juel, Knud</style></author><author><style face="normal" font="default" size="100%">Kabagambe, Edmond Kato</style></author><author><style face="normal" font="default" size="100%">Kan, Haidong</style></author><author><style face="normal" font="default" size="100%">Karam, Nadim E</style></author><author><style face="normal" font="default" size="100%">Karch, André</style></author><author><style face="normal" font="default" size="100%">Karema, Corine Kakizi</style></author><author><style face="normal" font="default" size="100%">Kaul, Anil</style></author><author><style face="normal" font="default" size="100%">Kawakami, Norito</style></author><author><style face="normal" font="default" size="100%">Kazanjan, Konstantin</style></author><author><style face="normal" font="default" size="100%">Kazi, Dhruv S</style></author><author><style face="normal" font="default" size="100%">Kemp, Andrew H</style></author><author><style face="normal" font="default" size="100%">Kengne, Andre Pascal</style></author><author><style face="normal" font="default" size="100%">Kereselidze, Maia</style></author><author><style face="normal" font="default" size="100%">Khader, Yousef Saleh</style></author><author><style face="normal" font="default" size="100%">Khalifa, Shams Eldin Ali Hassan</style></author><author><style face="normal" font="default" size="100%">Khan, Ejaz Ahmed</style></author><author><style face="normal" font="default" size="100%">Khang, Young-Ho</style></author><author><style face="normal" font="default" size="100%">Knibbs, Luke</style></author><author><style face="normal" font="default" size="100%">Kokubo, Yoshihiro</style></author><author><style face="normal" font="default" size="100%">Kosen, Soewarta</style></author><author><style face="normal" font="default" size="100%">Defo, Barthelemy Kuate</style></author><author><style face="normal" font="default" size="100%">Kulkarni, Chanda</style></author><author><style face="normal" font="default" size="100%">Kulkarni, Veena S</style></author><author><style face="normal" font="default" size="100%">Kumar, G Anil</style></author><author><style face="normal" font="default" size="100%">Kumar, Kaushalendra</style></author><author><style face="normal" font="default" size="100%">Kumar, Ravi B</style></author><author><style face="normal" font="default" size="100%">Kwan, Gene</style></author><author><style face="normal" font="default" size="100%">Lai, Taavi</style></author><author><style face="normal" font="default" size="100%">Lalloo, Ratilal</style></author><author><style face="normal" font="default" size="100%">Lam, Hilton</style></author><author><style face="normal" font="default" size="100%">Lansingh, Van C</style></author><author><style face="normal" font="default" size="100%">Larsson, Anders</style></author><author><style face="normal" font="default" size="100%">Lee, Jong-Tae</style></author><author><style face="normal" font="default" size="100%">Leigh, James</style></author><author><style face="normal" font="default" size="100%">Leinsalu, Mall</style></author><author><style face="normal" font="default" size="100%">Leung, Ricky</style></author><author><style face="normal" font="default" size="100%">Li, Xiaohong</style></author><author><style face="normal" font="default" size="100%">Li, Yichong</style></author><author><style face="normal" font="default" size="100%">Li, Yongmei</style></author><author><style face="normal" font="default" size="100%">Liang, Juan</style></author><author><style face="normal" font="default" size="100%">Liang, Xiaofeng</style></author><author><style face="normal" font="default" size="100%">Lim, Stephen S</style></author><author><style face="normal" font="default" size="100%">Lin, Hsien-Ho</style></author><author><style face="normal" font="default" size="100%">Lipshultz, Steven E</style></author><author><style face="normal" font="default" size="100%">Liu, Shiwei</style></author><author><style face="normal" font="default" size="100%">Liu, Yang</style></author><author><style face="normal" font="default" size="100%">Lloyd, Belinda K</style></author><author><style face="normal" font="default" size="100%">London, Stephanie J</style></author><author><style face="normal" font="default" size="100%">Lotufo, Paulo A</style></author><author><style face="normal" font="default" size="100%">Ma, Jixiang</style></author><author><style face="normal" font="default" size="100%">Ma, Stefan</style></author><author><style face="normal" font="default" size="100%">Machado, Vasco Manuel Pedro</style></author><author><style face="normal" font="default" size="100%">Mainoo, Nana Kwaku</style></author><author><style face="normal" font="default" size="100%">Majdan, Marek</style></author><author><style face="normal" font="default" size="100%">Mapoma, Christopher Chabila</style></author><author><style face="normal" font="default" size="100%">Marcenes, Wagner</style></author><author><style face="normal" font="default" size="100%">Marzan, Melvin Barrientos</style></author><author><style face="normal" font="default" size="100%">Mason-Jones, Amanda J</style></author><author><style face="normal" font="default" size="100%">Mehndiratta, Man Mohan</style></author><author><style face="normal" font="default" size="100%">Mejia-Rodriguez, Fabiola</style></author><author><style face="normal" font="default" size="100%">Memish, Ziad A</style></author><author><style face="normal" font="default" size="100%">Mendoza, Walter</style></author><author><style face="normal" font="default" size="100%">Miller, Ted R</style></author><author><style face="normal" font="default" size="100%">Mills, Edward J</style></author><author><style face="normal" font="default" size="100%">Mokdad, Ali H</style></author><author><style face="normal" font="default" size="100%">Mola, Glen Liddell</style></author><author><style face="normal" font="default" size="100%">Monasta, Lorenzo</style></author><author><style face="normal" font="default" size="100%">de la Cruz Monis, Jonathan</style></author><author><style face="normal" font="default" size="100%">Hernandez, Julio Cesar Montañez</style></author><author><style face="normal" font="default" size="100%">Moore, Ami R</style></author><author><style face="normal" font="default" size="100%">Moradi-Lakeh, Maziar</style></author><author><style face="normal" font="default" size="100%">Mori, Rintaro</style></author><author><style face="normal" font="default" size="100%">Mueller, Ulrich O</style></author><author><style face="normal" font="default" size="100%">Mukaigawara, Mitsuru</style></author><author><style face="normal" font="default" size="100%">Naheed, Aliya</style></author><author><style face="normal" font="default" size="100%">Naidoo, Kovin S</style></author><author><style face="normal" font="default" size="100%">Nand, Devina</style></author><author><style face="normal" font="default" size="100%">Nangia, Vinay</style></author><author><style face="normal" font="default" size="100%">Nash, Denis</style></author><author><style face="normal" font="default" size="100%">Nejjari, Chakib</style></author><author><style face="normal" font="default" size="100%">Nelson, Robert G</style></author><author><style face="normal" font="default" size="100%">Neupane, Sudan Prasad</style></author><author><style face="normal" font="default" size="100%">Newton, Charles R</style></author><author><style face="normal" font="default" size="100%">Ng, Marie</style></author><author><style face="normal" font="default" size="100%">Nieuwenhuijsen, Mark J</style></author><author><style face="normal" font="default" size="100%">Nisar, Muhammad Imran</style></author><author><style face="normal" font="default" size="100%">Nolte, Sandra</style></author><author><style face="normal" font="default" size="100%">Norheim, Ole F</style></author><author><style face="normal" font="default" size="100%">Nyakarahuka, Luke</style></author><author><style face="normal" font="default" size="100%">Oh, In-Hwan</style></author><author><style face="normal" font="default" size="100%">Ohkubo, Takayoshi</style></author><author><style face="normal" font="default" size="100%">Olusanya, Bolajoko O</style></author><author><style face="normal" font="default" size="100%">Omer, Saad B</style></author><author><style face="normal" font="default" size="100%">Opio, John Nelson</style></author><author><style face="normal" font="default" size="100%">Orisakwe, Orish Ebere</style></author><author><style face="normal" font="default" size="100%">Pandian, Jeyaraj D</style></author><author><style face="normal" font="default" size="100%">Papachristou, Christina</style></author><author><style face="normal" font="default" size="100%">Park, Jae-Hyun</style></author><author><style face="normal" font="default" size="100%">Caicedo, Angel J Paternina</style></author><author><style face="normal" font="default" size="100%">Patten, Scott B</style></author><author><style face="normal" font="default" size="100%">Paul, Vinod K</style></author><author><style face="normal" font="default" size="100%">Pavlin, Boris Igor</style></author><author><style face="normal" font="default" size="100%">Pearce, Neil</style></author><author><style face="normal" font="default" size="100%">Pereira, David M</style></author><author><style face="normal" font="default" size="100%">Pesudovs, Konrad</style></author><author><style face="normal" font="default" size="100%">Petzold, Max</style></author><author><style face="normal" font="default" size="100%">Poenaru, Dan</style></author><author><style face="normal" font="default" size="100%">Polanczyk, Guilherme V</style></author><author><style face="normal" font="default" size="100%">Polinder, Suzanne</style></author><author><style face="normal" font="default" size="100%">Pope, Dan</style></author><author><style face="normal" font="default" size="100%">Pourmalek, Farshad</style></author><author><style face="normal" font="default" size="100%">Qato, Dima</style></author><author><style face="normal" font="default" size="100%">Quistberg, D Alex</style></author><author><style face="normal" font="default" size="100%">Rafay, Anwar</style></author><author><style face="normal" font="default" size="100%">Rahimi, Kazem</style></author><author><style face="normal" font="default" size="100%">Rahimi-Movaghar, Vafa</style></author><author><style face="normal" font="default" size="100%">ur Rahman, Sajjad</style></author><author><style face="normal" font="default" size="100%">Raju, Murugesan</style></author><author><style face="normal" font="default" size="100%">Rana, Saleem M</style></author><author><style face="normal" font="default" size="100%">Refaat, Amany</style></author><author><style face="normal" font="default" size="100%">Ronfani, Luca</style></author><author><style face="normal" font="default" size="100%">Roy, Nobhojit</style></author><author><style face="normal" font="default" size="100%">Pimienta, Tania Georgina Sánchez</style></author><author><style face="normal" font="default" size="100%">Sahraian, Mohammad Ali</style></author><author><style face="normal" font="default" size="100%">Salomon, Joshua A</style></author><author><style face="normal" font="default" size="100%">Sampson, Uchechukwu</style></author><author><style face="normal" font="default" size="100%">Santos, Itamar S</style></author><author><style face="normal" font="default" size="100%">Sawhney, Monika</style></author><author><style face="normal" font="default" size="100%">Sayinzoga, Felix</style></author><author><style face="normal" font="default" size="100%">Schneider, Ione J C</style></author><author><style face="normal" font="default" size="100%">Schumacher, Austin</style></author><author><style face="normal" font="default" size="100%">Schwebel, David C</style></author><author><style face="normal" font="default" size="100%">Seedat, Soraya</style></author><author><style face="normal" font="default" size="100%">Sepanlou, Sadaf G</style></author><author><style face="normal" font="default" size="100%">Servan-Mori, Edson E</style></author><author><style face="normal" font="default" size="100%">Shakh-Nazarova, Marina</style></author><author><style face="normal" font="default" size="100%">Sheikhbahaei, Sara</style></author><author><style face="normal" font="default" size="100%">Shibuya, Kenji</style></author><author><style face="normal" font="default" size="100%">Shin, Hwashin Hyun</style></author><author><style face="normal" font="default" size="100%">Shiue, Ivy</style></author><author><style face="normal" font="default" size="100%">Sigfusdottir, Inga Dora</style></author><author><style face="normal" font="default" size="100%">Silberberg, Donald H</style></author><author><style face="normal" font="default" size="100%">Silva, Andrea P</style></author><author><style face="normal" font="default" size="100%">Singh, Jasvinder A</style></author><author><style face="normal" font="default" size="100%">Skirbekk, Vegard</style></author><author><style face="normal" font="default" size="100%">Sliwa, Karen</style></author><author><style face="normal" font="default" size="100%">Soshnikov, Sergey S</style></author><author><style face="normal" font="default" size="100%">Sposato, Luciano A</style></author><author><style face="normal" font="default" size="100%">Sreeramareddy, Chandrashekhar T</style></author><author><style face="normal" font="default" size="100%">Stroumpoulis, Konstantinos</style></author><author><style face="normal" font="default" size="100%">Sturua, Lela</style></author><author><style face="normal" font="default" size="100%">Sykes, Bryan L</style></author><author><style face="normal" font="default" size="100%">Tabb, Karen M</style></author><author><style face="normal" font="default" size="100%">Talongwa, Roberto Tchio</style></author><author><style face="normal" font="default" size="100%">Tan, Feng</style></author><author><style face="normal" font="default" size="100%">Teixeira, Carolina Maria</style></author><author><style face="normal" font="default" size="100%">Tenkorang, Eric Yeboah</style></author><author><style face="normal" font="default" size="100%">Terkawi, Abdullah Sulieman</style></author><author><style face="normal" font="default" size="100%">Thorne-Lyman, Andrew L</style></author><author><style face="normal" font="default" size="100%">Tirschwell, David L</style></author><author><style face="normal" font="default" size="100%">Towbin, Jeffrey A</style></author><author><style face="normal" font="default" size="100%">Tran, Bach X</style></author><author><style face="normal" font="default" size="100%">Tsilimbaris, Miltiadis</style></author><author><style face="normal" font="default" size="100%">Uchendu, Uche S</style></author><author><style face="normal" font="default" size="100%">Ukwaja, Kingsley N</style></author><author><style face="normal" font="default" size="100%">Undurraga, Eduardo A</style></author><author><style face="normal" font="default" size="100%">Uzun, Selen Begüm</style></author><author><style face="normal" font="default" size="100%">Vallely, Andrew J</style></author><author><style face="normal" font="default" size="100%">van Gool, Coen H</style></author><author><style face="normal" font="default" size="100%">Vasankari, Tommi J</style></author><author><style face="normal" font="default" size="100%">Vavilala, Monica S</style></author><author><style face="normal" font="default" size="100%">Venketasubramanian, N</style></author><author><style face="normal" font="default" size="100%">Villalpando, Salvador</style></author><author><style face="normal" font="default" size="100%">Violante, Francesco S</style></author><author><style face="normal" font="default" size="100%">Vlassov, Vasiliy Victorovich</style></author><author><style face="normal" font="default" size="100%">Vos, Theo</style></author><author><style face="normal" font="default" size="100%">Waller, Stephen</style></author><author><style face="normal" font="default" size="100%">Wang, Haidong</style></author><author><style face="normal" font="default" size="100%">Wang, Linhong</style></author><author><style face="normal" font="default" size="100%">Wang, XiaoRong</style></author><author><style face="normal" font="default" size="100%">Wang, Yanping</style></author><author><style face="normal" font="default" size="100%">Weichenthal, Scott</style></author><author><style face="normal" font="default" size="100%">Weiderpass, Elisabete</style></author><author><style face="normal" font="default" size="100%">Weintraub, Robert G</style></author><author><style face="normal" font="default" size="100%">Westerman, Ronny</style></author><author><style face="normal" font="default" size="100%">Wilkinson, James D</style></author><author><style face="normal" font="default" size="100%">Woldeyohannes, Solomon Meseret</style></author><author><style face="normal" font="default" size="100%">Wong, John Q</style></author><author><style face="normal" font="default" size="100%">Wordofa, Muluemebet Abera</style></author><author><style face="normal" font="default" size="100%">Xu, Gelin</style></author><author><style face="normal" font="default" size="100%">Yang, Yang C</style></author><author><style face="normal" font="default" size="100%">Yano, Yuichiro</style></author><author><style face="normal" font="default" size="100%">Yentur, Gokalp Kadri</style></author><author><style face="normal" font="default" size="100%">Yip, Paul</style></author><author><style face="normal" font="default" size="100%">Yonemoto, Naohiro</style></author><author><style face="normal" font="default" size="100%">Yoon, Seok-Jun</style></author><author><style face="normal" font="default" size="100%">Younis, Mustafa Z</style></author><author><style face="normal" font="default" size="100%">Yu, Chuanhua</style></author><author><style face="normal" font="default" size="100%">Jin, Kim Yun</style></author><author><style face="normal" font="default" size="100%">El Sayed Zaki, Maysaa</style></author><author><style face="normal" font="default" size="100%">Zhao, Yong</style></author><author><style face="normal" font="default" size="100%">Zheng, Yingfeng</style></author><author><style face="normal" font="default" size="100%">Zhou, Maigeng</style></author><author><style face="normal" font="default" size="100%">Zhu, Jun</style></author><author><style face="normal" font="default" size="100%">Zou, Xiao Nong</style></author><author><style face="normal" font="default" size="100%">Lopez, Alan D</style></author><author><style face="normal" font="default" size="100%">Naghavi, Mohsen</style></author><author><style face="normal" font="default" size="100%">Murray, Christopher J L</style></author><author><style face="normal" font="default" size="100%">Lozano, Rafael</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Global, regional, and national levels and causes of maternal mortality during 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013.</style></title><secondary-title><style face="normal" font="default" size="100%">Lancet</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Lancet</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Age Distribution</style></keyword><keyword><style  face="normal" font="default" size="100%">Cause of Death</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">Global Health</style></keyword><keyword><style  face="normal" font="default" size="100%">HIV Infections</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Maternal Mortality</style></keyword><keyword><style  face="normal" font="default" size="100%">Models, Statistical</style></keyword><keyword><style  face="normal" font="default" size="100%">Organizational Objectives</style></keyword><keyword><style  face="normal" font="default" size="100%">Pregnancy</style></keyword><keyword><style  face="normal" font="default" size="100%">Pregnancy Complications, Infectious</style></keyword><keyword><style  face="normal" font="default" size="100%">Risk Factors</style></keyword><keyword><style  face="normal" font="default" size="100%">Socioeconomic Factors</style></keyword><keyword><style  face="normal" font="default" size="100%">Time Factors</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2014 Sep 13</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">384</style></volume><pages><style face="normal" font="default" size="100%">980-1004</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;b&gt;BACKGROUND: &lt;/b&gt;The fifth Millennium Development Goal (MDG 5) established the goal of a 75% reduction in the maternal mortality ratio (MMR; number of maternal deaths per 100,000 livebirths) between 1990 and 2015. We aimed to measure levels and track trends in maternal mortality, the key causes contributing to maternal death, and timing of maternal death with respect to delivery.&lt;/p&gt;&lt;p&gt;&lt;b&gt;METHODS: &lt;/b&gt;We used robust statistical methods including the Cause of Death Ensemble model (CODEm) to analyse a database of data for 7065 site-years and estimate the number of maternal deaths from all causes in 188 countries between 1990 and 2013. We estimated the number of pregnancy-related deaths caused by HIV on the basis of a systematic review of the relative risk of dying during pregnancy for HIV-positive women compared with HIV-negative women. We also estimated the fraction of these deaths aggravated by pregnancy on the basis of a systematic review. To estimate the numbers of maternal deaths due to nine different causes, we identified 61 sources from a systematic review and 943 site-years of vital registration data. We also did a systematic review of reports about the timing of maternal death, identifying 142 sources to use in our analysis. We developed estimates for each country for 1990-2013 using Bayesian meta-regression. We estimated 95% uncertainty intervals (UIs) for all values.&lt;/p&gt;&lt;p&gt;&lt;b&gt;FINDINGS: &lt;/b&gt;292,982 (95% UI 261,017-327,792) maternal deaths occurred in 2013, compared with 376,034 (343,483-407,574) in 1990. The global annual rate of change in the MMR was -0·3% (-1·1 to 0·6) from 1990 to 2003, and -2·7% (-3·9 to -1·5) from 2003 to 2013, with evidence of continued acceleration. MMRs reduced consistently in south, east, and southeast Asia between 1990 and 2013, but maternal deaths increased in much of sub-Saharan Africa during the 1990s. 2070 (1290-2866) maternal deaths were related to HIV in 2013, 0·4% (0·2-0·6) of the global total. MMR was highest in the oldest age groups in both 1990 and 2013. In 2013, most deaths occurred intrapartum or postpartum. Causes varied by region and between 1990 and 2013. We recorded substantial variation in the MMR by country in 2013, from 956·8 (685·1-1262·8) in South Sudan to 2·4 (1·6-3·6) in Iceland.&lt;/p&gt;&lt;p&gt;&lt;b&gt;INTERPRETATION: &lt;/b&gt;Global rates of change suggest that only 16 countries will achieve the MDG 5 target by 2015. Accelerated reductions since the Millennium Declaration in 2000 coincide with increased development assistance for maternal, newborn, and child health. Setting of targets and associated interventions for after 2015 will need careful consideration of regions that are making slow progress, such as west and central Africa.&lt;/p&gt;&lt;p&gt;&lt;b&gt;FUNDING: &lt;/b&gt;Bill &amp; Melinda Gates Foundation.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">9947</style></issue><custom1><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/24797575?dopt=Abstract</style></custom1></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Barkokebas, Andreza</style></author><author><style face="normal" font="default" size="100%">de Albuquerque T Carvalho, Alessandra</style></author><author><style face="normal" font="default" size="100%">de Souza, Paulo Roberto Eleutério</style></author><author><style face="normal" font="default" size="100%">Gomez, Ricardo Santiago</style></author><author><style face="normal" font="default" size="100%">Xavier, Guilherme Machado</style></author><author><style face="normal" font="default" size="100%">Ribeiro, Camila Maria Beder</style></author><author><style face="normal" font="default" size="100%">Crovella, Sergio</style></author><author><style face="normal" font="default" size="100%">Porter, Stephen Ross</style></author><author><style face="normal" font="default" size="100%">Leão, Jair Carneiro</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Mannose-binding lectin gene (MBL-2) polymorphism in oral lichen planus.</style></title><secondary-title><style face="normal" font="default" size="100%">Clin Oral Investig</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Clin Oral Investig</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Adolescent</style></keyword><keyword><style  face="normal" font="default" size="100%">Adult</style></keyword><keyword><style  face="normal" font="default" size="100%">Aged</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">Gene Expression Regulation</style></keyword><keyword><style  face="normal" font="default" size="100%">Gene Frequency</style></keyword><keyword><style  face="normal" font="default" size="100%">Genes, Recessive</style></keyword><keyword><style  face="normal" font="default" size="100%">Genetic Variation</style></keyword><keyword><style  face="normal" font="default" size="100%">Genotype</style></keyword><keyword><style  face="normal" font="default" size="100%">Heterozygote</style></keyword><keyword><style  face="normal" font="default" size="100%">Homozygote</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Lichen Planus, Oral</style></keyword><keyword><style  face="normal" font="default" size="100%">Male</style></keyword><keyword><style  face="normal" font="default" size="100%">Mannose-Binding Lectin</style></keyword><keyword><style  face="normal" font="default" size="100%">Middle Aged</style></keyword><keyword><style  face="normal" font="default" size="100%">Mutation</style></keyword><keyword><style  face="normal" font="default" size="100%">Polymorphism, Genetic</style></keyword><keyword><style  face="normal" font="default" size="100%">Real-Time Polymerase Chain Reaction</style></keyword><keyword><style  face="normal" font="default" size="100%">Tumor Necrosis Factor-alpha</style></keyword><keyword><style  face="normal" font="default" size="100%">Young Adult</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2011</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2011 Oct</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">699-704</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;TNF-α may be associated with the etiopathogenesis of oral lichen planus (OLP), and it has been suggested that polymorphism of mannose-binding lectin (MBL) increases the in vitro production of TNF- α. The aim of the present study was to assess the relevance of genetic diversity of MBL in OLP. The study sample comprised 90 individuals, 45 OLP patients and 45 healthy volunteers. MBL-2 gene was amplified using real-time PCR. Frequency of A/A genotype was 55.6% in OLP and 53.3% in healthy volunteers. Likewise, A/0 heterozygote genotype was found in 42.2% and 35.6%; 2.2% and 11.1%, had the recessive 0/0 genotype respectively. Frequencies of the &quot;A&quot; and &quot;0&quot; alleles were 77% and 23% in the OLP group and 71.2% in control group. There were no statistically significant differences regarding genotype frequency (p = 0.546) or allele frequency (p = 0.497). In conclusion, no significant association was found between polymorphism of MBL-2 gene and OLP.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><custom1><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/20499118?dopt=Abstract</style></custom1></record></records></xml>