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Responsabile: Aristotle University of Thessaloniki (AUTH), GREECE
The Call for Application for the position of Early Stage Researcher and the selection procedures as published, are in accordance with the Regulations on the appointment of collaborators pursuant to Art. 7, comma 6 of the legislative Decree n.165 30/03/2011, adopted by the Institute by Decree n. 332 15/09/2009. The research contract awarded by IRCCS Burlo Garofolo to the winning Early Stage Researcher will be a collaboration contract of the duration of 36 months.
Please be aware that the applications can be submitted ONLY through the NEUROSOME web site www.neurosome.eu
Il bando di avviso per la posizione di giovane ricercatore e le procedure di selezione, così come pubblicate, sono in linea con il Regolamento recante disciplina per il conferimento di incarichi di collaborazione a norma del’Art.7, comma 6, del Decreto Legislativo 30 marzo 2001 n. 165, adottato dall’Istituto con decreto n. 332 del 15 settembre 2009. La tipologia di contratto conferito dall’IRCCS Burlo Garofolo al Giovane Ricercatore vincitore della selezione sarà un contratto di collaborazione della durata di 36 mesi.
Attenzione: Le domande di partecipazione devono essere inviate attraverso il sito NEUROSOME www.neurosome.eu
Description of the project
The project aims at exploring the environmental causes of neurodevelopmental disorders and their complex interplay with genetic predisposition and susceptibility. This will be achieved by developing a functional link between human biological monitoring (HBM) through data on exposure to specific environmental compounds, based on the evaluation and reanalysis of existing cohort biosamples (e.g. PHIME, INMA, PROBE, Taranto, CROME, HEALS, PELAGIE, MECANA), and neurodevelopmental disorders, using the latest advances in environmental health science, namely the “exposome” approach for cumulative health risk and impact assessment.
The NEUROSOME project uses high dimensional biological data generated from multi-omics technological platforms to develop functional links among the different components of environmental, exposure, HBM, toxicological and epidemiological studies to develop an integrative exposure biology-based framework to understand the causal associations between exposure to organic compounds and metals and neurodevelopmental disorders and the extent to which the differences observed among individuals with similar exposure levels, may be explained by genetics (e.g. differences in toxicokinetics associated to polymorphisms of metabolising enzymes), by sociodemographic factors (e.g. parental educational status) or by co-exposures to multiple environmental chemicals.
The NEUROSOME project will also contribute to raising the level of understanding among policy makers and increasing awareness of the public and competent authorities in the participating countries, regarding the possibility of using advanced biomonitoring and environment and health data analysis for efficient exposure assessment and health risk management. The project will support the Environment and Health Action Plan (EHAP), the Chemicals Safety Regulation (REACH), and the 7th Environmental Action Plan of the European Commission by extending health impact assessment (HIA) methods and tools to draw environment-wide association studies between environmental stressors and human health to improve chemical risk assessment including the health risk of mixtures and emerging compounds.
Lead:
Aristotle University of Thessaloniki (AUTH), GREECE;
Partner institutions:
Istituto Superiore di Sanità (ISS), Italy;
Agencia Estatal Consejo Superior Deinvestigaciones Cientificas (Csic), Spain;
Institut Jozef Stefan (JSI), Slovenia;
Universite Paris Descartes (UPD), France;
Universitat Rovira I Virgili (URV), Spain;
Kai Ergastiriakes Ypiresies Toxikologias Farmakologias Kai Bioiatrikis (TP), Greece;
Istituto Universitario di Studi Superiori di Pavia (IUSS), Italy,
IRCCS Materno-Infantile Burlo Garofolo (BURLO), Italy
